Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ASIP_HUMAN
Description:agouti signaling protein [Source:HGNC Symbol;Acc:745]
Location:chr20 q11.22
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S35LRDDRsLRSNSAgoutiPhosphoSitePlus

Dephosphorylation site
ASIP_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000454804*133KCOSMICMelanoma21499247
ENSP00000364092*133KCOSMICMelanoma21499247
ENSP00000364092D109NCOSMICCentral Nervous System Neoplasms18772396

Differential expressed protein
ASIP_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ASIP_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ASIP_HUMANMGRN1_HUMANligand -> receptorHPMR
ASIP_HUMANATRN_HUMANligand -> receptorHPMR
ASIP_HUMANMSHR_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04916Melanogenesis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0009755hormone-mediated signaling pathwayIEAbiological_process
GO:0005615extracellular spaceTAScellular_component
GO:0005576extracellular regionIEAcellular_component
GO:0006091generation of precursor metabolites and energyIEAbiological_process
GO:0031781type 3 melanocortin receptor bindingIEAmolecular_function
GO:0007165signal transductionTASbiological_process
GO:0031779melanocortin receptor bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0071514genetic imprintingIEAbiological_process
GO:0043473pigmentationIEAbiological_process
GO:0040030regulation of molecular function, epigeneticIEAbiological_process
GO:0008343adult feeding behaviorIEAbiological_process
GO:0032438melanosome organizationIEAbiological_process
GO:0031782type 4 melanocortin receptor bindingIEAmolecular_function
GO:0007267cell-cell signalingTASbiological_process
GO:0032402melanosome transportIEAbiological_process
GO:0042438melanin biosynthetic processIEAbiological_process
GO:0005102receptor bindingTASmolecular_function


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