Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:APC4_HUMAN
Description:anaphase promoting complex subunit 4 [Source:HGNC Symbol;Acc:19990]
Location:chr4 p15.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S488DDDLVsPPNTEPhosphoSitePlus
Y516PLLFPyYPRKSPhosphoSitePlus
S779EVLSEsEAENQPLK1phosphoELM
S736SCVLSsNLRHVHPRD
Y469NRKGKyFNVERPhosphoSitePlus; phosphoELM
S757WELDEsSDEEEPhosphoSitePlus
T87FALADtKKIVLPhosphoSitePlus
Y625FGSFTyATTEKPhosphoSitePlus
T628FTYATtEKVRRPhosphoSitePlus
S758ELDESsDEEEEPhosphoSitePlus
S777KEEVLsESEAEPhosphoSitePlus; HPRD; phosphoELM
T627SFTYAtTEKVRPhosphoSitePlus
T429AMLRMtEDHVLPhosphoSitePlus
S779EVLSEsEAENQPhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site
APC4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000318775I155VHPIColorectal Cancer16959974
ENSP00000318775P515SCOSMICMelanoma21499247
ENSP00000318775I155VSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000318775V220LCOSMICOvarian Cancer21720365
ENSP00000318775L671FCOSMICPancreatic Cancer
ENSP00000318775V220LTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
APC4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
APC4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK1_HUMANAPC4_HUMANkinase -> substrateRegPhos
PLK1_HUMANAPC4_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ZAGL2_HUMANAPC4_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04114Oocyte meiosis
hsa04914Progesterone-mediated oocyte maturation
hsa04120Ubiquitin mediated proteolysis
hsa05166HTLV-I infection
hsa04110Cell cycle

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005680anaphase-promoting complexIEAcellular_component
GO:0000075cell cycle checkpointTASbiological_process
GO:0007067mitosisTASbiological_process
GO:0070979protein K11-linked ubiquitinationIDAbiological_process
GO:0007094mitotic cell cycle spindle assembly checkpointTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0051437positive regulation of ubiquitin-protein ligase acTASbiological_process
GO:0051301cell divisionIEAbiological_process
GO:0004842ubiquitin-protein ligase activityTASmolecular_function
GO:0005829cytosolTAScellular_component
GO:0051436negative regulation of ubiquitin-protein ligase acTASbiological_process
GO:0000090mitotic anaphaseTASbiological_process
GO:0030071regulation of mitotic metaphase/anaphase transitioIEAbiological_process
GO:0006511ubiquitin-dependent protein catabolic processTASbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0019903protein phosphatase bindingIPImolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0051439regulation of ubiquitin-protein ligase activity inTASbiological_process
GO:0031145anaphase-promoting complex-dependent proteasomal uIEAbiological_process


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