| UniProt/SwissProt ID: | AMPH_HUMAN |
| Description: | amphiphysin [Source:HGNC Symbol;Acc:471] |
| Location: | chr7 p14.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S293 | PARPRsPSQTR | PhosphoSitePlus | |
| S507 | VIEPAsNHEEE | HPRD | |
| S464 | AGEGVsLEEAK | HPRD | |
| T260 | LRIAKtPSPPE | PhosphoSitePlus; HPRD | |
| T456 | DLGMDtRAEEP | PhosphoSitePlus | |
| S285 | TLAPAsPAPAR | CDK1 | HPRD |
| S285 | TLAPAsPAPAR | PhosphoSitePlus | |
| S549 | VIEPAsNHEEE | PhosphoSitePlus; HPRD | |
| S285 | TLAPAsPAPAR | CDK_group | phosphoELM; RegPhos |
| S272 | PSPLPsPTASP | CDK_group | phosphoELM; RegPhos |
| T6 | MADIKtGIFAK | IFT57 | PhosphoSitePlus; SysPTM |
| S276 | PSPTAsPNHTL | CDK5 | HPRD; RegPhos |
| S272 | PSPLPsPTASP | CDC2 | RegPhos |
| T6 | IFAK | phosphoELM; SysPTM | |
| T387 | WDLWTtSTDLV | PhosphoSitePlus | |
| T350 | VKKEEtLLDLD | PhosphoSitePlus | |
| S272 | PSPLPsPTASP | PhosphoSitePlus | |
| S276 | PSPTAsPNHTL | CDC2 | RegPhos |
| S506 | AGEGVsLEEAK | HPRD; RegPhos | |
| S272 | PSPLPsPTASP | CDK1 | HPRD |
| S272 | PSPLPsPTASP | CDK5 | HPRD; RegPhos |
| T310 | PLPKVtPTKEL | PhosphoSitePlus | |
| S250 | IQGAPsDSGPL | RegPhos | |
| T312 | PKVTPtKELQQ | PhosphoSitePlus | |
| S74 | GMQEAsMKLTE | BAR; IFT57 | PhosphoSitePlus |
| Y145 | RKLVDyDSARH | BAR | PhosphoSitePlus |
| T34 | GKADEtKDEQF | BAR; IFT57 | PhosphoSitePlus |
| S276 | PSPTAsPNHTL | CDK1 | HPRD |
| S285 | TLAPAsPAPAR | CDK5 | HPRD; RegPhos |
| S276 | PSPTAsPNHTL | CDK_group | phosphoELM; RegPhos |
| S285 | TLAPAsPAPAR | CDC2 | RegPhos |
| S276 | PSPTAsPNHTL | PhosphoSitePlus | |
| S293 | PARPRsPSQTR | DYRK1A | phosphoELM |
| S295 | RPRSPsQTRKG | PhosphoSitePlus | |
| S262 | IAKTPsPPEEP | PhosphoSitePlus | |
| T445 | PLAAVtPAVGL | PhosphoSitePlus | |
| Dephosphorylation site |
| AMPH_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000348602 | D353N | COSMIC | Melanoma | 21499247 | ENSP00000348602 | P273L | COSMIC | Skin Cancer | 21984974 | ENSP00000348602 | W382* | COSMIC | Skin Cancer | 21984974 | ENSP00000348602 | P129S | COSMIC | Skin Cancer | 21984974 | ENSP00000348602 | E558K | COSMIC | Skin Cancer | 21984974 | ENSP00000348602 | P249S | COSMIC | Ovarian Cancer | 21720365 | ENSP00000348602 | T386M | COSMIC | Hepatocellular Carcinoma |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000348602 | Uterine Cancer | Treatment(none vs. transfected with the pOP13 vector that containing E7) | cell line | Down | 14997504 | |
| Hyperphosphorylation site |
| AMPH_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK5_HUMAN | AMPH_HUMAN | kinase -> substrate | RegPhos |
| ZAGL2_HUMAN | AMPH_HUMAN | kinase -> substrate | RegPhos |
| CDK1_HUMAN | AMPH_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04666 | Fc gamma R-mediated phagocytosis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007612 | learning | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0008021 | synaptic vesicle | TAS | cellular_component |
| GO:0019904 | protein domain specific binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006897 | endocytosis | TAS | biological_process |
| GO:0007268 | synaptic transmission | TAS | biological_process |
| GO:0030672 | synaptic vesicle membrane | IEA | cellular_component |
| GO:0030054 | cell junction | IEA | cellular_component |
| GO:0048488 | synaptic vesicle endocytosis | IEA | biological_process |
| GO:0015629 | actin cytoskeleton | TAS | cellular_component |
| GO:0008021 | synaptic vesicle | IEA | cellular_component |