Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ADDB_HUMAN
Description:adducin 2 (beta) [Source:HGNC Symbol;Acc:244]
Location:chr2 p13.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S713KFRTPsFLKKSPKC_groupphosphoELM; RegPhos
S726KEKVPKC_groupphosphoELM
S713KFRTPsFLKKSPKACaRegPhos
S535SPSTEsQLMSKPhosphoSitePlus; RegPhos
S726KEKVEsPKACaRegPhos
S532KSRSPsTESQLPhosphoSitePlus; HPRD; RegPhos
S713KFRTPsFLKKSPKCz(PKC zetaRegPhos
Y489QFVPLyTDPQEPhosphoSitePlus
S726KEKVphosphoELM
S604ASPVQsPAKEAPhosphoSitePlus; HPRD
S528VIAEKsRSPSTPhosphoSitePlus
S713KFRTPsFLKKSPKCa(PKC alphaRegPhos
T626SLEEGtKKTETPhosphoSitePlus
S726KEKVEsPKCdRegPhos
S726KEKVEs_____PhosphoSitePlus
S703PSKSPsKKKKKPKCa(PKC alphaRegPhos
S11VPEAAsPPPPQHPRD
S718SFLKKsKKKEKPhosphoSitePlus; HPRD
S699PEGSPsKSPSKPhosphoSitePlus; HPRD
S600KSAPAsPVQSPPhosphoSitePlus; HPRD; RegPhos
S592PEEPGsPAKSAPhosphoSitePlus; HPRD; RegPhos
T55QKKRVtMILQSMacPhosphoSitePlus
S726KEKVPRKACAHPRD
S693TSGPMsPEGSPPhosphoSitePlus; HPRD
S726KEKVEsPKA_groupRegPhos
T533SRSPStESQLMPhosphoSitePlus
T585DGEKEtAPEEPPhosphoSitePlus
S726KEKVPRKCDHPRD
S713KFRTPsFLKKSPKCdRegPhos
S713KFRTPsFLKKSPhosphoSitePlus; phosphoELM
T684TSKDKtESVTSPhosphoSitePlus
S726KEKVEsPKC_groupRegPhos
T688KTESVtSGPMSRegPhos
S619PLVSPsKSLEEPhosphoSitePlus; HPRD
S703PSKSPsKKKKKPKC_alphaphosphoELM
S713KFRTPsFLKKSPRKCDHPRD
S697MSPEGsPSKSPPhosphoSitePlus; HPRD
S713KFRTPsFLKKSPRKACAHPRD
T561PFSQLtDQELEHPRD; RegPhos
S530AEKSRsPSTESPhosphoSitePlus
T711KKKFRtPSFLKPhosphoSitePlus
S613EAETKsPLVSPPhosphoSitePlus; HPRD
Y440NTPNTyLRVNVPhosphoSitePlus
S701GSPSKsPSKKKPhosphoSitePlus; HPRD
T55QKKRVtMILQSPKA_groupphosphoELM; RegPhos
S596GSPAKsAPASPPhosphoSitePlus; HPRD
S703PSKSPsKKKKKPKC_groupRegPhos
Y31EDDPEyMRLRNMacPhosphoSitePlus
T611AKEAEtKSPLVPhosphoSitePlus
Y377LDNLGyRTGYTPhosphoSitePlus
S617KSPLVsPSKSLPhosphoSitePlus; HPRD
S703PSKSPsKKKKKPhosphoSitePlus; HPRD
S621VSPSKsLEEGTPhosphoSitePlus; HPRD
S713KFRTPsFLKKSPKA_groupRegPhos

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y568TDQELEEyKKEVERKPTPRZ1HPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000347972E130KCOSMICSkin Cancer21984974
ENSP00000347972R420*COSMICOvarian Cancer21720365
ENSP00000347972G591ACOSMICOvarian Cancer21720365

Differential expressed protein
ADDB_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ADDB_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANADDB_HUMANkinase -> substrateRegPhos
KPCZ_HUMANADDB_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANADDB_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KPCD_HUMANADDB_HUMANkinase -> substrateHPRD
PTPRZ_HUMANADDB_HUMANphosphatase -> substrateHPRD

Function Annotation
KEGG Pathway
ADDB_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051015actin filament bindingIDAmolecular_function
GO:0051016barbed-end actin filament cappingIDAbiological_process
GO:0016020membraneIEAcellular_component
GO:0051017actin filament bundle assemblyIDAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0030097hemopoiesisIEAbiological_process
GO:0030507spectrin bindingIDAmolecular_function
GO:0008290F-actin capping protein complexIDAcellular_component
GO:0003779actin bindingTASmolecular_function
GO:0046982protein heterodimerization activityIPImolecular_function
GO:0046872metal ion bindingIEAmolecular_function
GO:0005516calmodulin bindingIEAmolecular_function
GO:0042803protein homodimerization activityIPImolecular_function
GO:0030036actin cytoskeleton organizationICbiological_process
GO:0005198structural molecule activityIEAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0032092positive regulation of protein bindingIDAbiological_process


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