| UniProt/SwissProt ID: | ADDB_HUMAN |
| Description: | adducin 2 (beta) [Source:HGNC Symbol;Acc:244] |
| Location: | chr2 p13.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S713 | KFRTPsFLKKS | PKC_group | phosphoELM; RegPhos |
| S726 | KEKV | PKC_group | phosphoELM |
| S713 | KFRTPsFLKKS | PKACa | RegPhos |
| S535 | SPSTEsQLMSK | PhosphoSitePlus; RegPhos | |
| S726 | KEKVEs | PKACa | RegPhos |
| S532 | KSRSPsTESQL | PhosphoSitePlus; HPRD; RegPhos | |
| S713 | KFRTPsFLKKS | PKCz(PKC zeta | RegPhos |
| Y489 | QFVPLyTDPQE | PhosphoSitePlus | |
| S726 | KEKV | phosphoELM | |
| S604 | ASPVQsPAKEA | PhosphoSitePlus; HPRD | |
| S528 | VIAEKsRSPST | PhosphoSitePlus | |
| S713 | KFRTPsFLKKS | PKCa(PKC alpha | RegPhos |
| T626 | SLEEGtKKTET | PhosphoSitePlus | |
| S726 | KEKVEs | PKCd | RegPhos |
| S726 | KEKVEs_____ | PhosphoSitePlus | |
| S703 | PSKSPsKKKKK | PKCa(PKC alpha | RegPhos |
| S11 | VPEAAsPPPPQ | HPRD | |
| S718 | SFLKKsKKKEK | PhosphoSitePlus; HPRD | |
| S699 | PEGSPsKSPSK | PhosphoSitePlus; HPRD | |
| S600 | KSAPAsPVQSP | PhosphoSitePlus; HPRD; RegPhos | |
| S592 | PEEPGsPAKSA | PhosphoSitePlus; HPRD; RegPhos | |
| T55 | QKKRVtMILQS | Mac | PhosphoSitePlus |
| S726 | KEKV | PRKACA | HPRD |
| S693 | TSGPMsPEGSP | PhosphoSitePlus; HPRD | |
| S726 | KEKVEs | PKA_group | RegPhos |
| T533 | SRSPStESQLM | PhosphoSitePlus | |
| T585 | DGEKEtAPEEP | PhosphoSitePlus | |
| S726 | KEKV | PRKCD | HPRD |
| S713 | KFRTPsFLKKS | PKCd | RegPhos |
| S713 | KFRTPsFLKKS | PhosphoSitePlus; phosphoELM | |
| T684 | TSKDKtESVTS | PhosphoSitePlus | |
| S726 | KEKVEs | PKC_group | RegPhos |
| T688 | KTESVtSGPMS | RegPhos | |
| S619 | PLVSPsKSLEE | PhosphoSitePlus; HPRD | |
| S703 | PSKSPsKKKKK | PKC_alpha | phosphoELM |
| S713 | KFRTPsFLKKS | PRKCD | HPRD |
| S697 | MSPEGsPSKSP | PhosphoSitePlus; HPRD | |
| S713 | KFRTPsFLKKS | PRKACA | HPRD |
| T561 | PFSQLtDQELE | HPRD; RegPhos | |
| S530 | AEKSRsPSTES | PhosphoSitePlus | |
| T711 | KKKFRtPSFLK | PhosphoSitePlus | |
| S613 | EAETKsPLVSP | PhosphoSitePlus; HPRD | |
| Y440 | NTPNTyLRVNV | PhosphoSitePlus | |
| S701 | GSPSKsPSKKK | PhosphoSitePlus; HPRD | |
| T55 | QKKRVtMILQS | PKA_group | phosphoELM; RegPhos |
| S596 | GSPAKsAPASP | PhosphoSitePlus; HPRD | |
| S703 | PSKSPsKKKKK | PKC_group | RegPhos |
| Y31 | EDDPEyMRLRN | Mac | PhosphoSitePlus |
| T611 | AKEAEtKSPLV | PhosphoSitePlus | |
| Y377 | LDNLGyRTGYT | PhosphoSitePlus | |
| S617 | KSPLVsPSKSL | PhosphoSitePlus; HPRD | |
| S703 | PSKSPsKKKKK | PhosphoSitePlus; HPRD | |
| S621 | VSPSKsLEEGT | PhosphoSitePlus; HPRD | |
| S713 | KFRTPsFLKKS | PKA_group | RegPhos |
| Dephosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y568 | TDQELEEyKKEVERK | PTPRZ1 | HPRD |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000347972 | E130K | COSMIC | Skin Cancer | 21984974 | ENSP00000347972 | R420* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000347972 | G591A | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| ADDB_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ADDB_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | ADDB_HUMAN | kinase -> substrate | RegPhos |
| KPCZ_HUMAN | ADDB_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCA_HUMAN | ADDB_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| KPCD_HUMAN | ADDB_HUMAN | kinase -> substrate | HPRD |
| PTPRZ_HUMAN | ADDB_HUMAN | phosphatase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| ADDB_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0051015 | actin filament binding | IDA | molecular_function |
| GO:0051016 | barbed-end actin filament capping | IDA | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0051017 | actin filament bundle assembly | IDA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0030097 | hemopoiesis | IEA | biological_process |
| GO:0030507 | spectrin binding | IDA | molecular_function |
| GO:0008290 | F-actin capping protein complex | IDA | cellular_component |
| GO:0003779 | actin binding | TAS | molecular_function |
| GO:0046982 | protein heterodimerization activity | IPI | molecular_function |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0005516 | calmodulin binding | IEA | molecular_function |
| GO:0042803 | protein homodimerization activity | IPI | molecular_function |
| GO:0030036 | actin cytoskeleton organization | IC | biological_process |
| GO:0005198 | structural molecule activity | IEA | molecular_function |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0032092 | positive regulation of protein binding | IDA | biological_process |