Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ADDA_HUMAN
Description:adducin 1 (alpha) [Source:HGNC Symbol;Acc:243]
Location:chr4 p16.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S408KSKKYsDVEVPPRKACAHPRD
S427ASDGDsGTCSPPhosphoSitePlus
S600EQKEKsPPDQPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y550IIEKEyQPHVIPhosphoSitePlus
S714GSPGKsPSKKKPhosphoSitePlus
S726KFRTPsFLKKSPKC_groupRegPhos
S695EEAAPsAVEEGPKCdRegPhos
S710PGSDGsPGKSPPhosphoSitePlus; HPRD; RegPhos
S716PGKSPsKKKKKPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S59QKKRVsMILQSPhosphoSitePlus
S436SPLRHsFQKQQPRKACAHPRD
T480EDGHRtSTSAVROCK_groupphosphoELM; RegPhos
S436SPLRHsFQKQQPKACaRegPhos
T513GHRTStSAVPNHPRD
S12AAVVTsPPPTTPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S464EGQNGsSPKSKPhosphoSitePlus; HPRD
S617RKQKGsEENLDHPRD
T614HPPPStPIKLEPhosphoSitePlus; HPRD; RegPhos
T445QQREKtRWLNSPhosphoSitePlus
S738AADPGsDGSPGHPRD
S757KFRTPsFLKKSHPRD
T331EIQVRtLASAGPhosphoSitePlus; HPRD; phosphoELM
S408KSKKYsDVEVPPKACaRegPhos
S747PGKSPsKKKKKHPRD
S5AAVVPKC_alphaphosphoELM
S408KSKKYsDVEVPPKA_groupphosphoELM; RegPhos
T511EDGHRtSTSAVROCK1HPRD
S613PHPPPsTPIKLPhosphoSitePlus; HPRD
T706PTEAPtEASPEHPRD
S726KFRTPsFLKKSPKCz(PKC zetaRegPhos
S726EEAAPsAVEEGPRKCDHPRD
S334VRTLAsAGGPDPhosphoSitePlus; HPRD; phosphoELM
S420SVTGYsFASDGHPRD
S716PGKSPsKKKKKPKC_groupRegPhos; SysPTM
S481DGHRTsTSAVPPhosphoSitePlus
S436SPLRHsFQKQQPhosphoSitePlus; phosphoELM
S726KFRTPsFLKKSPKA_groupRegPhos
S366GEGTGsPPKWQPhosphoSitePlus; HPRD; phosphoELM
S457RGDEAsEEGQNPhosphoSitePlus
S423GYSFAsDGDSGPhosphoSitePlus; HPRD
S358SRSPGsPVGEGPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T429DGDSGtCSPLRPhosphoSitePlus; HPRD
S695EEAAPsAVEEGPRKCDHPRD
S741PGSDGsPGKSPHPRD
S436SPLRHsFQKQQPKA_groupphosphoELM; RegPhos
T559VIVSTtGPNPFPhosphoSitePlus
S5MNGDSrAAVVPKCz(PKC zetaRegPhos
S735KSKKKsDS___PhosphoSitePlus
S726KFRTPsFLKKSPKCdRegPhos
T445QQREKtRWLNSROCK1HPRD; phosphoELM; RegPhos
S59QKKRVsMILQSPKA_groupphosphoELM; RegPhos
S716PGKSPsKKKKKPKCa(PKC alphaRegPhos; SysPTM
T482GHRTStSAVPNPhosphoSitePlus; HPRD
T724KKKFRtPSFLKPhosphoSitePlus
S5MNGDSrAAVVPKCa(PKC alphaRegPhos
S716PGKSPsKKKKKPKC_alphaphosphoELM; SysPTM
S726KFRTPsFLKKSPhosphoSitePlus; HPRD; phosphoELM
S669AHRPPsPTEAPPhosphoSitePlus; HPRD; SysPTM
S726KFRTPsFLKKSPKC_alphaphosphoELM
S353KYKAKsRSPGSPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T645HPPPStPIKLEHPRD
S631EQKEKsPPDQPHPRD
S586RKQKGsEENLDPhosphoSitePlus; HPRD; RegPhos
S731SFLKKsKKKSDPhosphoSitePlus
S481DGHRTsTSAVPPKA_groupphosphoELM; RegPhos
S465GQNGSsPKSKTPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S408KSKKYsDVEVPPhosphoSitePlus
T364PVGEGtGSPPKHPRD
S726KFRTPsFLKKSPKCa(PKC alphaRegPhos
S707AADPGsDGSPGPhosphoSitePlus; HPRD; RegPhos
S431DSGTCsPLRHSPhosphoSitePlus; HPRD; phosphoELM
T11RAAVVtSPPPTPhosphoSitePlus; HPRD
S5AAVVphosphoELM
T445QQREKtRWLNSROCK_groupphosphoELM; RegPhos
S355KAKSRsPGSPVPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S737KKKSDs_____PhosphoSitePlus
S483HRTSTsAVPNLRegPhos
S5AAVVPKC_zetaphosphoELM
S644PHPPPsTPIKLHPRD
T675PTEAPtEASPEHPRD; SysPTM
S700AHRPPsPTEAPHPRD
Y35ENNPEyLRERNPhosphoSitePlus
T480EDGHRtSTSAVROCK1HPRD; RegPhos
S64SMILQsPAFCEPhosphoSitePlus

Dephosphorylation site
ADDA_HUMAN do not have dephosphorylation site.

Mutation site
ADDA_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000399828Breast CancerNormal vs. CancertissueDown0.4420739354
ENSP00000399828Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
ADDA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCD_HUMANADDA_HUMANkinase -> substrateHPRD
KPCZ_HUMANADDA_HUMANkinase -> substrateRobert H Newman (2013)
ROCK1_HUMANADDA_HUMANkinase -> substrateRegPhos
KPCA_HUMANADDA_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
ZAGL2_HUMANADDA_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
ADDA_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005634nucleusIDAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0020027hemoglobin metabolic processIEAbiological_process
GO:0030507spectrin bindingIDAmolecular_function
GO:0032092positive regulation of protein bindingIDAbiological_process
GO:0006921cellular component disassembly involved in executiTASbiological_process
GO:0071300cellular response to retinoic acidIEAbiological_process
GO:0006884cell volume homeostasisIEAbiological_process
GO:0030425dendriteIEAcellular_component
GO:0046872metal ion bindingIEAmolecular_function
GO:0042803protein homodimerization activityIPImolecular_function
GO:0000902cell morphogenesisIEAbiological_process
GO:0014069postsynaptic densityIEAcellular_component
GO:0051016barbed-end actin filament cappingIDAbiological_process
GO:0051015actin filament bindingIDAmolecular_function
GO:0005856cytoskeletonIEAcellular_component
GO:0048873homeostasis of number of cells within a tissueIEAbiological_process
GO:0005198structural molecule activityIEAmolecular_function
GO:0005516calmodulin bindingIEAmolecular_function
GO:0030218erythrocyte differentiationIEAbiological_process
GO:0006987activation of signaling protein activity involved TASbiological_process
GO:0005829cytosolTAScellular_component
GO:0030968endoplasmic reticulum unfolded protein responseTASbiological_process
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0045807positive regulation of endocytosisIEAbiological_process
GO:0043197dendritic spineIEAcellular_component
GO:0003779actin bindingTASmolecular_function
GO:0008290F-actin capping protein complexIDAcellular_component
GO:0030036actin cytoskeleton organizationICbiological_process
GO:0035264multicellular organism growthIEAbiological_process
GO:0045202synapseIEAcellular_component
GO:0042608T cell receptor bindingIEAmolecular_function
GO:0008134transcription factor bindingIPImolecular_function
GO:0045766positive regulation of angiogenesisIEAbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0016020membraneIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0046982protein heterodimerization activityIPImolecular_function
GO:0051017actin filament bundle assemblyIDAbiological_process


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