| UniProt/SwissProt ID: | ADCY9_HUMAN |
| Description: | adenylate cyclase 9 [Source:HGNC Symbol;Acc:240] |
| Location: | chr16 p13.3 |
| Node attribute: | effector |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S357 | EESENsVKRHA | PhosphoSitePlus; HPRD; phosphoELM | |
| T494 | GVHTGtVLCGI | Guanylate_cyc | PhosphoSitePlus |
| S364 | KRHATsSPKNR | PhosphoSitePlus | |
| S39 | PKQLSsNSHPK | PhosphoSitePlus | |
| Y1225 | GYDFDyRGTVN | Guanylate_cyc | PhosphoSitePlus |
| Y122 | RYALFyIGFAC | TM | PhosphoSitePlus |
| T363 | VKRHAtSSPKN | PhosphoSitePlus | |
| S365 | RHATSsPKNRK | PhosphoSitePlus; HPRD; SysPTM | |
| Y1221 | LSKMGyDFDYR | Guanylate_cyc | PhosphoSitePlus |
| S1259 | HQLSIsPDIRV | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S56 | SSSCSsSGDSG | PhosphoSitePlus | |
| Y133 | LLWSIyFAVHM | TM | PhosphoSitePlus |
| S1257 | PQHQLsISPDI | PhosphoSitePlus; HPRD | |
| S354 | QGDEEsENSVK | PhosphoSitePlus; HPRD; phosphoELM | |
| S1307 | KDAHLsPKRPW | PhosphoSitePlus; HPRD | |
| T1109 | IEKIKtIGATY | Guanylate_cyc | PhosphoSitePlus |
| S38 | NPKQLsSNSHP | PhosphoSitePlus | |
| Y172 | LYARHyAWTSL | TM | PhosphoSitePlus |
| S25 | DSSGDsNSVRV | PhosphoSitePlus | |
| Dephosphorylation site |
| ADCY9_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000294016 | C583F | COSMIC | Ovarian Cancer | 21720365 | ENSP00000294016 | E1314K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000294016 | R1310S | COSMIC | Ovarian Cancer | 21720365 | ENSP00000294016 | S900L | COSMIC | Intestines Cancer | 17932254 | ENSP00000294016 | M1197V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000294016 | V157L | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000294016 | Testicular Cancer | Normal vs. Cancer | cell line | Up | 18489135 | |
| Hyperphosphorylation site |
| ADCY9_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GNAS2_HUMAN | ADCY9_HUMAN | Gprotein -> effector | gpDB |
| GNAS1_HUMAN | ADCY9_HUMAN | Gprotein -> effector | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04972 | Pancreatic secretion |
| hsa04540 | Gap junction |
| hsa00230 | Purine metabolism |
| hsa04976 | Bile secretion |
| hsa04916 | Melanogenesis |
| hsa04270 | Vascular smooth muscle contraction |
| hsa05414 | Dilated cardiomyopathy |
| hsa05166 | HTLV-I infection |
| hsa05110 | Vibrio cholerae infection |
| hsa04970 | Salivary secretion |
| hsa04727 | GABAergic synapse |
| hsa04723 | Retrograde endocannabinoid signaling |
| hsa05032 | Morphine addiction |
| hsa04912 | GnRH signaling pathway |
| hsa04724 | Glutamatergic synapse |
| hsa04725 | Cholinergic synapse |
| hsa04020 | Calcium signaling pathway |
| hsa04062 | Chemokine signaling pathway |
| hsa04962 | Vasopressin-regulated water reabsorption |
| hsa04914 | Progesterone-mediated oocyte maturation |
| hsa04961 | Endocrine and other factor-regulated calcium reabs |
| hsa04114 | Oocyte meiosis |
| hsa04971 | Gastric acid secretion |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0071377 | cellular response to glucagon stimulus | TAS | biological_process |
| GO:0035556 | intracellular signal transduction | IEA | biological_process |
| GO:0007268 | synaptic transmission | TAS | biological_process |
| GO:0007193 | adenylate cyclase-inhibiting G-protein coupled rec | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0006171 | cAMP biosynthetic process | IEA | biological_process |
| GO:0008543 | fibroblast growth factor receptor signaling pathwa | TAS | biological_process |
| GO:0009190 | cyclic nucleotide biosynthetic process | IEA | biological_process |
| GO:0004016 | adenylate cyclase activity | IEA | molecular_function |
| GO:0007173 | epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007202 | activation of phospholipase C activity | TAS | biological_process |
| GO:0006833 | water transport | TAS | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0007189 | adenylate cyclase-activating G-protein coupled rec | TAS | biological_process |
| GO:0034199 | activation of protein kinase A activity | TAS | biological_process |
| GO:0006112 | energy reserve metabolic process | TAS | biological_process |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0055085 | transmembrane transport | TAS | biological_process |
| GO:0016849 | phosphorus-oxygen lyase activity | IEA | molecular_function |
| GO:0048011 | nerve growth factor receptor signaling pathway | TAS | biological_process |