Phosphorylation

Protein information

UniProt/SwissProt ID:	ACV1C_HUMAN
Description:	activin A receptor, type IC [Source:HGNC Symbol;Acc:18123]
Location:	chr2 q24.1
Node attribute:	receptor; kinase

ACV1C_HUMAN do not have phosphorylation site.

ACV1C_HUMAN do not have dephosphorylation site.

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000335139	Q108E	BIOMART	Breast Cancer	21930507, 21930502
ENSP00000243349	Q265E	BIOMART	Breast Cancer	21930507, 21930502
ENSP00000335178	Q185E	BIOMART	Breast Cancer	21930507, 21930502
ENSP00000243349	I319N	Ding2008, BIOMART	Lung Cancer	18948947, 21930507, 21930502
ENSP00000243349	W267R	Greenman2007, HPI	Lung Cancer	16140923, 17344846, 18428421

ACV1C_HUMAN is not differential expressed protein.

ACV1C_HUMAN do not have hyperphosphorylation site.

Source	Target	Relationship	Resource
NODAL_HUMAN	ACV1C_HUMAN	ligand -> receptor	HPMR
ACV1C_HUMAN	SMAD2_HUMAN	kinase -> substrate	KEGG

KEGG Pathway

KEGG ID	Pathway
hsa04350	TGF-beta signaling pathway

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:1901164	negative regulation of trophoblast cell migration	IDA	biological_process
GO:0004675	transmembrane receptor protein serine/threonine ki	IEA	molecular_function
GO:0030154	cell differentiation	IDA	biological_process
GO:0046872	metal ion binding	IC	molecular_function
GO:0006468	protein phosphorylation	IC	biological_process
GO:0038092	nodal signaling pathway	IMP	biological_process
GO:0004672	protein kinase activity	IEA	molecular_function
GO:0032868	response to insulin stimulus	IEA	biological_process
GO:0042981	regulation of apoptotic process	IDA	biological_process
GO:0016020	membrane	IEA	cellular_component
GO:0048179	activin receptor complex	IDA	cellular_component
GO:0046676	negative regulation of insulin secretion	IEA	biological_process
GO:0016772	transferase activity, transferring phosphorus-cont	IEA	molecular_function
GO:0038100	nodal binding	IMP	molecular_function
GO:1901383	negative regulation of chorionic trophoblast cell	IMP	biological_process
GO:0043280	positive regulation of cysteine-type endopeptidase	IMP	biological_process
GO:0019915	lipid storage	IEA	biological_process
GO:0004713	protein tyrosine kinase activity	IEA	molecular_function
GO:0009749	response to glucose stimulus	IEA	biological_process
GO:0016361	activin receptor activity, type I	IDA	molecular_function
GO:0005024	transforming growth factor beta-activated receptor	IEA	molecular_function
GO:0002021	response to dietary excess	IEA	biological_process
GO:0005524	ATP binding	IEA	molecular_function

Human Phosphorylation Mediated
Signaling Transduction Network