Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ACTA_HUMAN
Description:actin, alpha 2, smooth muscle, aorta [Source:HGNC Symbol;Acc:130]
Location:chr10 q23.31
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S201TERGYsFVTTAActinPhosphoSitePlus
Y296IRKDLyANNVLActinPhosphoSitePlus
S241SSLEKsYELPDActinPhosphoSitePlus; SysPTM
T280GIHETtYNSIMActinPhosphoSitePlus
T204GYSFVtTAEREActinPhosphoSitePlus
Y242SLEKSyELPDGActinPhosphoSitePlus
T320MQKEItALAPSActinPhosphoSitePlus
T128QIMFEtFNVPAActinPhosphoSitePlus
S350GSILAsLSTFQActinPhosphoSitePlus
Y145AVLSLyASGRTActinPhosphoSitePlus
Y171PIYEGyALPHAActinPhosphoSitePlus
Y220KEKLCyVALDFActinPhosphoSitePlus
S283ETTYNsIMKCDActinPhosphoSitePlus
S62GDEAQsKRGILActinPhosphoSitePlus
T68KRGILtLKYPIActinPhosphoSitePlus
T79EHGIItNWDDMActinPhosphoSitePlus
S325TALAPsTMKIKActinPhosphoSitePlus
T305VLSGGtTMYPGActinPhosphoSitePlus
T196LMKILtERGYSActinPhosphoSitePlus
S157GIVLDsGDGVTActinPhosphoSitePlus
T251DGQVItIGNERActinPhosphoSitePlus
S35RAVFPsIVGRPActinPhosphoSitePlus
Y168HNVPIyEGYALActinPhosphoSitePlus
Y93WHHSFyNELRVActinPhosphoSitePlus
T306LSGGTtMYPGIActinPhosphoSitePlus
S325TALAPsTMKIKHPRD
Y55GQKDSyVGDEAActinPhosphoSitePlus
Y190RDLTDyLMKILActinPhosphoSitePlus
T188AGRDLtDYLMKActinPhosphoSitePlus
Y281IHETTyNSIMKActinPhosphoSitePlus
Y364ISKQEyDEAGPActinPhosphoSitePlus
T326ALAPStMKIKIHPRD
Y71ILTLKyPIEHGActinPhosphoSitePlus
S267TLFQPsFIGMEActinPhosphoSitePlus
Y200LTERGySFVTTActinPhosphoSitePlus
S54MGQKDsYVGDEActinPhosphoSitePlus
Y308GGTTMyPGIADActinPhosphoSitePlus
T326ALAPStMKIKIActinPhosphoSitePlus

Dephosphorylation site
ACTA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000402373P166ABIOMARTBreast Cancer21930507, 21930502
ENSP00000224784Q123EBIOMARTBreast Cancer21930507, 21930502
ENSP00000402373Q123EBIOMARTBreast Cancer21930507, 21930502
ENSP00000224784P166ABIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000402373Esophageal CancerNormal vs. CancertissueDown0.419142970
ENSP00000402373Breast CancerNormal vs. CancertissueUp1.420087651
ENSP00000402373Breast CancerNormal vs. CancertissueDown0.7320739354
ENSP00000402373Breast CancerNormal vs. CancertissueDown0.7320739354
ENSP00000402373Oral CancerNormal vs. CancertissueUp3.719691830
ENSP00000402373Neoplasms by Histologic TypeCancer vs. Cancer (subtype)tissueUp7.516807943
ENSP00000402373Ovarian CancerTreatment (chemotherapy-sensitive vs. chemotherapy-resistant)tissueUp2.719422301

Hyperphosphorylation site
ACTA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
P53_HUMANACTA_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
ACTA_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006936muscle contractionTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0015629actin cytoskeletonIEAcellular_component
GO:0008217regulation of blood pressureIEAbiological_process
GO:0030485smooth muscle contractile fiberIEAcellular_component
GO:0043234protein complexIDAcellular_component
GO:0005829cytosolTAScellular_component
GO:0014829vascular smooth muscle contractionIEAbiological_process
GO:0009615response to virusIEPbiological_process
GO:0072144glomerular mesangial cell developmentIEPbiological_process
GO:0005856cytoskeletonIEAcellular_component


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