Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:5HT2A_HUMAN
Description:5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled [Source:HGNC Symbol;Acc:5293]
Location:chr13 q14.2
Node attribute:receptor; GPCR

Phosphorylation site
5HT2A_HUMAN do not have phosphorylation site.

Dephosphorylation site
5HT2A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000367959Q398ECOSMICOvarian Cancer21720365
ENSP00000367959T39ICOSMICCentral Nervous System Neoplasms18772890
ENSP00000367959N54SCOSMICHead and Neck Cancer21798897
ENSP00000367959V221ACOSMICOvarian Cancer21720365
ENSP00000367959T253ICOSMICHepatocellular Carcinoma21822264
ENSP00000367959F186LCOSMICOvarian Cancer21720365
ENSP00000367959E102KCOSMICHead and Neck Cancer21984974

Differential expressed protein
5HT2A_HUMAN is not differential expressed protein.

Hyperphosphorylation site
5HT2A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TPH1_HUMAN5HT2A_HUMANligand -> receptorHPMR
5HT2A_HUMANGNAQ_HUMANGPCR -> GproteingpDB
5HT2A_HUMANGNA11_HUMANGPCR -> GproteingpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04080Neuroactive ligand-receptor interaction
hsa04540Gap junction
hsa04726Serotonergic synapse
hsa04020Calcium signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007568agingIEAbiological_process
GO:0014065phosphatidylinositol 3-kinase cascadeIMPbiological_process
GO:0019233sensory perception of painIEAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0008219cell deathIEAbiological_process
GO:0004435phosphatidylinositol phospholipase C activityIMPmolecular_function
GO:0006661phosphatidylinositol biosynthetic processIMPbiological_process
GO:0051967negative regulation of synaptic transmission, glutIEAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0045907positive regulation of vasoconstrictionIEAbiological_process
GO:0051209release of sequestered calcium ion into cytosolIDAbiological_process
GO:0030431sleepIEAbiological_process
GO:0043198dendritic shaftIEAcellular_component
GO:0007613memoryIEAbiological_process
GO:0070371ERK1 and ERK2 cascadeIMPbiological_process
GO:0051378serotonin bindingIDAmolecular_function
GO:0051378serotonin bindingIEAmolecular_function
GO:0005829cytosolIEAcellular_component
GO:0004993serotonin receptor activityIDAmolecular_function
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0042493response to drugIDAbiological_process
GO:0001659temperature homeostasisIEAbiological_process
GO:0043406positive regulation of MAP kinase activityIEAbiological_process
GO:00718861-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine bindiIDAmolecular_function
GO:0007268synaptic transmissionTASbiological_process
GO:0007210serotonin receptor signaling pathwayIMPbiological_process
GO:0001965G-protein alpha-subunit bindingIEAmolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0016020membraneIEAcellular_component
GO:0043267negative regulation of potassium ion transportIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0006950response to stressIEAbiological_process
GO:0032403protein complex bindingIEAmolecular_function
GO:0008144drug bindingIDAmolecular_function
GO:0007208phospholipase C-activating serotonin receptor signIEAbiological_process
GO:0030425dendriteIEAcellular_component
GO:0014059regulation of dopamine secretionIEAbiological_process
GO:0004993serotonin receptor activityIEAmolecular_function


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