| UniProt/SwissProt ID: | 3BP2_HUMAN |
| Description: | SH3-domain binding protein 2 [Source:HGNC Symbol;Acc:10825] |
| Location: | chr4 p16.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S425 | GQSFRsFSFEK | PhosphoSitePlus | |
| T273 | PRVPAtPRRMS | PhosphoSitePlus | |
| Y183 | DEDDSyLEPDS | PhosphoSitePlus; phosphoELM; RegPhos | |
| S225 | MPRAHsFTSKG | PKC_alpha | phosphoELM |
| S444 | TGGDDsDEDYE | PhosphoSitePlus | |
| Y448 | DSDEDyEKVPL | SYK | HPRD; RegPhos |
| S336 | CDKLKsFHLSP | PhosphoSitePlus | |
| Y183 | DEDDSyLEPDS | SYK | HPRD; RegPhos |
| Y448 | DSDEDyEKVPL | PhosphoSitePlus | |
| S416 | PHLQRsPPDGQ | PhosphoSitePlus | |
| S427 | SFRSFsFEKPR | PhosphoSitePlus | |
| S278 | TPRRMsDPPLS | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S225 | MPRAHsFTSKG | PhosphoSitePlus | |
| Y174 | TDNEDyEHDDE | SYK | HPRD; RegPhos |
| Y174 | TDNEDyEHDDE | PhosphoSitePlus; phosphoELM; RegPhos | |
| S225 | MPRAHsFTSKG | PKCa(PKC alpha | RegPhos |
| T39 | HKKGGtQLQLL | PH | PhosphoSitePlus |
| Dephosphorylation site |
| 3BP2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000409746 | P201T | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000424846 | P201T | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000388152 | P229T | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000348685 | P201T | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000403231 | P201T | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| 3BP2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| 3BP2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KSYK_HUMAN | 3BP2_HUMAN | kinase -> substrate | RegPhos; NetPath |
| ZAGL2_HUMAN | 3BP2_HUMAN | kinase -> substrate | RegPhos |
| KPCA_HUMAN | 3BP2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04650 | Natural killer cell mediated cytotoxicity |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0017124 | SH3 domain binding | IEA | molecular_function |
| GO:0005543 | phospholipid binding | IEA | molecular_function |
| GO:0005070 | SH3/SH2 adaptor activity | TAS | molecular_function |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |