| UniProt/SwissProt ID: | 1433T_HUMAN |
| Description: | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide [Source:HGNC Symbol;Acc:12854] |
| Location: | chr2 p25.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S232 | LWTSDsAGEEC | CK1_group | phosphoELM; RegPhos; SysPTM |
| S232 | LWTSDsAGEEC | BCR | HPRD; RegPhos; SysPTM |
| S232 | LWTSDsAGEEC | phosphoELM; SysPTM | |
| T215 | SYKDStLIMQL | 14-3-3 | PhosphoSitePlus |
| T110 | LIANAtNPESK | HPRD | |
| T95 | LRSICtTVLEL | HPRD | |
| S230 | LTLWTsDSAGE | 14-3-3 | PhosphoSitePlus; SysPTM |
| Y211 | LNEDSyKDSTL | 14-3-3 | PhosphoSitePlus |
| S230 | LTLWTsDSAGE | HPRD; phosphoELM; SysPTM | |
| Y149 | NSQGAyQEAFD | 14-3-3 | PhosphoSitePlus |
| T229 | NLTLWtSDSAG | 14-3-3 | PhosphoSitePlus |
| S232 | LWTSDsAGEEC | CK1a | RegPhos; SysPTM |
| S232 | LWTSDsAGEEC | CK1_alpha | phosphoELM; SysPTM |
| T141 | DDRKQtIDNSQ | 14-3-3 | PhosphoSitePlus |
| Y19 | EQAERyDDMAT | 14-3-3 | PhosphoSitePlus |
| S232 | LWTSDsAGEEC | CK1a(CK1 alpha | RegPhos; SysPTM |
| Y48 | LLSVAyKNVVG | 14-3-3 | PhosphoSitePlus |
| S210 | TLNEDsYKDST | 14-3-3 | PhosphoSitePlus |
| S156 | EAFDIsKKEMQ | 14-3-3 | PhosphoSitePlus |
| S45 | ERNLLsVAYKN | 14-3-3 | PhosphoSitePlus |
| Y82 | QLIKDyREKVE | 14-3-3 | PhosphoSitePlus |
| S232 | LWTSDsAGEEC | 14-3-3 | PhosphoSitePlus; SysPTM |
| S214 | DSYKDsTLIMQ | HPRD | |
| Y125 | KMKGDyFRYLA | 14-3-3 | PhosphoSitePlus |
| S45 | ERNLLsVAYKN | HPRD | |
| S232 | LWTSDsAGEEC | CSNK1A1 | HPRD; SysPTM |
| Dephosphorylation site |
| 1433T_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000371267 | Y179C | COSMIC | Breast Cancer | 20668451 | ENSP00000238081 | Y179C | COSMIC | Breast Cancer | 20668451 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000371267 | Pancreatic Cancer | Normal vs. Cancer | tissue | Up | 6.2 | 16215274 | ENSP00000371267 | Gastric Cancer | Metastasis | cell line | Up | 2.5 | 17022644 | ENSP00000371267 | Uterine Cancer | Normal vs. Cancer | tissue | Up | 17902640 | ENSP00000371267 | Hepatocellular Carcinoma | Metastasis | cell line | Down | 0.55 | 19016532 | ENSP00000371267 | Gastric Cancer | Metastasis | cell line | Up | 2.5 | 17022644 |
| Hyperphosphorylation site |
| 1433T_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| BCR_HUMAN | 1433T_HUMAN | kinase -> substrate | HPRD; RegPhos |
| KC1A_HUMAN | 1433T_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05203 | Viral carcinogenesis |
| hsa05169 | Epstein-Barr virus infection |
| hsa04114 | Oocyte meiosis |
| hsa04110 | Cell cycle |
| hsa05130 | Pathogenic Escherichia coli infection |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0007264 | small GTPase mediated signal transduction | IEA | biological_process |
| GO:0047485 | protein N-terminus binding | IPI | molecular_function |
| GO:0071889 | 14-3-3 protein binding | IEA | molecular_function |
| GO:0019904 | protein domain specific binding | IEA | molecular_function |
| GO:0006605 | protein targeting | IEA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0043234 | protein complex | IEA | cellular_component |
| GO:0045892 | negative regulation of transcription, DNA-dependen | IDA | biological_process |