Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:1433T_HUMAN
Description:tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide [Source:HGNC Symbol;Acc:12854]
Location:chr2 p25.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S232LWTSDsAGEECCK1_groupphosphoELM; RegPhos; SysPTM
S232LWTSDsAGEECBCRHPRD; RegPhos; SysPTM
S232LWTSDsAGEECphosphoELM; SysPTM
T215SYKDStLIMQL14-3-3PhosphoSitePlus
T110LIANAtNPESKHPRD
T95LRSICtTVLELHPRD
S230LTLWTsDSAGE14-3-3PhosphoSitePlus; SysPTM
Y211LNEDSyKDSTL14-3-3PhosphoSitePlus
S230LTLWTsDSAGEHPRD; phosphoELM; SysPTM
Y149NSQGAyQEAFD14-3-3PhosphoSitePlus
T229NLTLWtSDSAG14-3-3PhosphoSitePlus
S232LWTSDsAGEECCK1aRegPhos; SysPTM
S232LWTSDsAGEECCK1_alphaphosphoELM; SysPTM
T141DDRKQtIDNSQ14-3-3PhosphoSitePlus
Y19EQAERyDDMAT14-3-3PhosphoSitePlus
S232LWTSDsAGEECCK1a(CK1 alphaRegPhos; SysPTM
Y48LLSVAyKNVVG14-3-3PhosphoSitePlus
S210TLNEDsYKDST14-3-3PhosphoSitePlus
S156EAFDIsKKEMQ14-3-3PhosphoSitePlus
S45ERNLLsVAYKN14-3-3PhosphoSitePlus
Y82QLIKDyREKVE14-3-3PhosphoSitePlus
S232LWTSDsAGEEC14-3-3PhosphoSitePlus; SysPTM
S214DSYKDsTLIMQHPRD
Y125KMKGDyFRYLA14-3-3PhosphoSitePlus
S45ERNLLsVAYKNHPRD
S232LWTSDsAGEECCSNK1A1HPRD; SysPTM

Dephosphorylation site
1433T_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000371267Y179CCOSMICBreast Cancer20668451
ENSP00000238081Y179CCOSMICBreast Cancer20668451

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000371267Pancreatic CancerNormal vs. CancertissueUp6.216215274
ENSP00000371267Gastric CancerMetastasiscell lineUp2.517022644
ENSP00000371267Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000371267Hepatocellular CarcinomaMetastasiscell lineDown0.5519016532
ENSP00000371267Gastric CancerMetastasiscell lineUp2.517022644

Hyperphosphorylation site
1433T_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
BCR_HUMAN1433T_HUMANkinase -> substrateHPRD; RegPhos
KC1A_HUMAN1433T_HUMANkinase -> substrateHPRD; Robert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05203Viral carcinogenesis
hsa05169Epstein-Barr virus infection
hsa04114Oocyte meiosis
hsa04110Cell cycle
hsa05130Pathogenic Escherichia coli infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0007264small GTPase mediated signal transductionIEAbiological_process
GO:0047485protein N-terminus bindingIPImolecular_function
GO:007188914-3-3 protein bindingIEAmolecular_function
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0006605protein targetingIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0043234protein complexIEAcellular_component
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process


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