| UniProt/SwissProt ID: | 1433S_HUMAN |
| Description: | stratifin [Source:HGNC Symbol;Acc:10773] |
| Location: | chr1 p36.11 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S248 | PQEPQs | RegPhos; SysPTM | |
| S45 | ERNLLsVAYKN | 14-3-3; DUF837 | PhosphoSitePlus |
| S64 | WRVLSsIEQKS | RegPhos | |
| S186 | YEIANsPEEAI | MAPK8 | phosphoELM |
| S5 | _MERAsLIQKA | 14-3-3; DUF837 | PhosphoSitePlus |
| S248 | PQEPQs_____ | PhosphoSitePlus; SysPTM | |
| S149 | IDSARsAYQEA | 14-3-3; TPR_12 | PhosphoSitePlus |
| Y213 | LSEDSyKDSTL | HPRD | |
| S146 | KRIIDsARSAY | HPRD | |
| S216 | DSYKDsTLIMQ | HPRD; RegPhos | |
| S186 | YEIANsPEEAI | 14-3-3; TPR_12 | PhosphoSitePlus |
| Y127 | KMKGDyYRYLA | 14-3-3; TPR_12 | PhosphoSitePlus |
| T217 | SYKDStLIMQL | 14-3-3 | PhosphoSitePlus |
| Y151 | SARSAyQEAMD | 14-3-3; TPR_12 | PhosphoSitePlus |
| Y19 | EQAERyEDMAA | 14-3-3; DUF837 | PhosphoSitePlus |
| S146 | KRIIDsARSAY | 14-3-3; TPR_12 | PhosphoSitePlus |
| S5 | IQKA | HPRD | |
| Y128 | MKGDYyRYLAE | 14-3-3; TPR_12 | PhosphoSitePlus |
| S186 | YEIANsPEEAI | JNK1(MAPK8 | RegPhos |
| Y48 | LLSVAyKNVVG | 14-3-3; DUF837 | PhosphoSitePlus |
| S248 | PQEP | HPRD; phosphoELM; SysPTM | |
| Dephosphorylation site |
| 1433S_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000340989 | E133K | COSMIC | Skin Cancer | 21984974 | ENSP00000340989 | R18C | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000340989 | Hepatocellular Carcinoma | Normal vs. Cancer | cell line | Down | 0.15 | 18646787 | ENSP00000340989 | Hepatocellular Carcinoma | Normal vs. Cancer | cell line | Down | 0.2 | 18646787 | ENSP00000340989 | Gastric Cancer | Metastasis | cell line | Up | 2.4 | 17022644 | ENSP00000340989 | Oral Premalignant Lesions | Normal vs. Cancer | tissue | Down | 0.74 | 19072117 | ENSP00000340989 | Oral Premalignant Lesions | Normal vs. Cancer | tissue | Up | 2.1 | 19072117 | ENSP00000340989 | Oral Premalignant Lesions | Normal vs. Cancer | tissue | Up | 1.9 | 19072117 | ENSP00000340989 | Oral Premalignant Lesions | Normal vs. Cancer | tissue | Up | 1.5 | 19072117 | ENSP00000340989 | Oral Premalignant Lesions | Normal vs. Cancer | tissue | Up | 1.8 | 19072117 | ENSP00000340989 | Oral Premalignant Lesions | Normal vs. Cancer | tissue | Up | 1.6 | 19072117 | ENSP00000340989 | Oral Cancer | Normal vs. Cancer | tissue | Up | 3.6 | 16889763 | ENSP00000340989 | Breast Cancer | Normal vs. Cancer | tissue | Down | 12687611 | ENSP00000340989 | Breast Cancer | Normal vs. Cancer | tissue | Up | 3.7 | 16470630 | ENSP00000340989 | Breast Cancer | Treatment (none vs. multidrug resistant) | cell line | Up | 5.7 | 16540677 | ENSP00000340989 | Non-small cell lung carcinoma | Normal vs. Cancer | cell line | Down | 15359725 | ENSP00000340989 | Non-small cell lung carcinoma | Metastasis | cell line | Down | 17418446 | ENSP00000340989 | Gastric Cancer | Metastasis | cell line | Up | 2.4 | 17022644 | ENSP00000340989 | Breast Cancer | Normal vs. Cancer | cell line | Down | 0.14 | 18821527 | ENSP00000340989 | breast ductal carcinoma | Normal vs. Cancer | tissue | Up | 18564057 | ENSP00000340989 | Ovarian Cancer | Treatment (chemotherapy-sensitive vs. chemotherapy-resistant) | tissue | Down | 0.49 | 19422301 | ENSP00000340989 | Gastric Cancer | Normal vs. Cancer | cell line | Up | 6.3 | 20812763 | ENSP00000340989 | Gastric Cancer | Normal vs. Cancer | cell line | Up | 3.9 | 20812763 | ENSP00000340989 | Uterine Cancer | Normal vs. Cancer | cell line | Down | 0.1 | 15838902 | ENSP00000340989 | pancreatic ductal adenocarcinoma | Normal vs. Cancer | tissue | Up | 17492507 |
| Hyperphosphorylation site |
| 1433S_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| P53_HUMAN | 1433S_HUMAN | TF -> target gene | TRANSFAC |
| P63_HUMAN | 1433S_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| 1433S_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005615 | extracellular space | TAS | cellular_component |
| GO:0008630 | intrinsic apoptotic signaling pathway in response | IDA | biological_process |
| GO:0030307 | positive regulation of cell growth | IEA | biological_process |
| GO:0043154 | negative regulation of cysteine-type endopeptidase | IDA | biological_process |
| GO:0030216 | keratinocyte differentiation | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0019901 | protein kinase binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0019904 | protein domain specific binding | IEA | molecular_function |
| GO:0043588 | skin development | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0000079 | regulation of cyclin-dependent protein kinase acti | IEA | biological_process |
| GO:0043616 | keratinocyte proliferation | IEA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0001836 | release of cytochrome c from mitochondria | IDA | biological_process |
| GO:0051219 | phosphoprotein binding | IEA | molecular_function |
| GO:0051726 | regulation of cell cycle | IEA | biological_process |
| GO:0006915 | apoptotic process | IDA | biological_process |
| GO:0046827 | positive regulation of protein export from nucleus | IEA | biological_process |
| GO:0008285 | negative regulation of cell proliferation | IEA | biological_process |
| GO:0006469 | negative regulation of protein kinase activity | TAS | biological_process |
| GO:0008426 | protein kinase C inhibitor activity | TAS | molecular_function |