Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:1433S_HUMAN
Description:stratifin [Source:HGNC Symbol;Acc:10773]
Location:chr1 p36.11
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S248PQEPQsRegPhos; SysPTM
S45ERNLLsVAYKN14-3-3; DUF837PhosphoSitePlus
S64WRVLSsIEQKSRegPhos
S186YEIANsPEEAIMAPK8phosphoELM
S5_MERAsLIQKA14-3-3; DUF837PhosphoSitePlus
S248PQEPQs_____PhosphoSitePlus; SysPTM
S149IDSARsAYQEA14-3-3; TPR_12PhosphoSitePlus
Y213LSEDSyKDSTLHPRD
S146KRIIDsARSAYHPRD
S216DSYKDsTLIMQHPRD; RegPhos
S186YEIANsPEEAI14-3-3; TPR_12PhosphoSitePlus
Y127KMKGDyYRYLA14-3-3; TPR_12PhosphoSitePlus
T217SYKDStLIMQL14-3-3PhosphoSitePlus
Y151SARSAyQEAMD14-3-3; TPR_12PhosphoSitePlus
Y19EQAERyEDMAA14-3-3; DUF837PhosphoSitePlus
S146KRIIDsARSAY14-3-3; TPR_12PhosphoSitePlus
S5IQKAHPRD
Y128MKGDYyRYLAE14-3-3; TPR_12PhosphoSitePlus
S186YEIANsPEEAIJNK1(MAPK8RegPhos
Y48LLSVAyKNVVG14-3-3; DUF837PhosphoSitePlus
S248PQEPHPRD; phosphoELM; SysPTM

Dephosphorylation site
1433S_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000340989E133KCOSMICSkin Cancer21984974
ENSP00000340989R18CBIOMARTHepatocellular Carcinoma21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000340989Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.1518646787
ENSP00000340989Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.218646787
ENSP00000340989Gastric CancerMetastasiscell lineUp2.417022644
ENSP00000340989Oral Premalignant LesionsNormal vs. CancertissueDown0.7419072117
ENSP00000340989Oral Premalignant LesionsNormal vs. CancertissueUp2.119072117
ENSP00000340989Oral Premalignant LesionsNormal vs. CancertissueUp1.919072117
ENSP00000340989Oral Premalignant LesionsNormal vs. CancertissueUp1.519072117
ENSP00000340989Oral Premalignant LesionsNormal vs. CancertissueUp1.819072117
ENSP00000340989Oral Premalignant LesionsNormal vs. CancertissueUp1.619072117
ENSP00000340989Oral CancerNormal vs. CancertissueUp3.616889763
ENSP00000340989Breast CancerNormal vs. CancertissueDown12687611
ENSP00000340989Breast CancerNormal vs. CancertissueUp3.716470630
ENSP00000340989Breast CancerTreatment (none vs. multidrug resistant)cell lineUp5.716540677
ENSP00000340989Non-small cell lung carcinomaNormal vs. Cancercell lineDown15359725
ENSP00000340989Non-small cell lung carcinomaMetastasiscell lineDown17418446
ENSP00000340989Gastric CancerMetastasiscell lineUp2.417022644
ENSP00000340989Breast CancerNormal vs. Cancercell lineDown0.1418821527
ENSP00000340989breast ductal carcinomaNormal vs. CancertissueUp18564057
ENSP00000340989Ovarian CancerTreatment (chemotherapy-sensitive vs. chemotherapy-resistant)tissueDown0.4919422301
ENSP00000340989Gastric CancerNormal vs. Cancercell lineUp6.320812763
ENSP00000340989Gastric CancerNormal vs. Cancercell lineUp3.920812763
ENSP00000340989Uterine CancerNormal vs. Cancercell lineDown0.115838902
ENSP00000340989pancreatic ductal adenocarcinomaNormal vs. CancertissueUp17492507

Hyperphosphorylation site
1433S_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
P53_HUMAN1433S_HUMANTF -> target geneTRANSFAC
P63_HUMAN1433S_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
1433S_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005615extracellular spaceTAScellular_component
GO:0008630intrinsic apoptotic signaling pathway in response IDAbiological_process
GO:0030307positive regulation of cell growthIEAbiological_process
GO:0043154negative regulation of cysteine-type endopeptidaseIDAbiological_process
GO:0030216keratinocyte differentiationIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0007165signal transductionTASbiological_process
GO:0019901protein kinase bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0043588skin developmentIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0000079regulation of cyclin-dependent protein kinase actiIEAbiological_process
GO:0043616keratinocyte proliferationIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0001836release of cytochrome c from mitochondriaIDAbiological_process
GO:0051219phosphoprotein bindingIEAmolecular_function
GO:0051726regulation of cell cycleIEAbiological_process
GO:0006915apoptotic processIDAbiological_process
GO:0046827positive regulation of protein export from nucleusIEAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0006469negative regulation of protein kinase activityTASbiological_process
GO:0008426protein kinase C inhibitor activityTASmolecular_function


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