| UniProt/SwissProt ID: | ZN746_HUMAN |
| Description: | zinc finger protein 746 [Source:HGNC Symbol;Acc:21948] |
| Location: | chr7 q36.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S481 | GAPDGsGPGTG | PhosphoSitePlus | |
| Y74 | TLLQEyGLLQR | DUF3669 | PhosphoSitePlus |
| Y137 | LVSLDyAISKP | PhosphoSitePlus | |
| T69 | WAVLGtLLQEY | DUF3669 | PhosphoSitePlus |
| S499 | GGGGGsGGGSA | PhosphoSitePlus | |
| Dephosphorylation site |
| ZN746_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000345140 | R31C | COSMIC | Ovarian Cancer | 21720365 | ENSP00000345140 | L625F | COSMIC | Skin Cancer | 21984974 | ENSP00000345140 | S490- | Sjoblom2006 | Breast Cancer | 16959974 | ENSP00000345140 | R346P | COSMIC | Ovarian Cancer | 21720365 | ENSP00000345140 | S490del | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000345140 | G215V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000345140 | T561M | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| ZN746_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ZN746_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MARK2_HUMAN | ZN746_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| ZN746_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0031625 | ubiquitin protein ligase binding | IEA | molecular_function |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0070997 | neuron death | IDA | biological_process |
| GO:0044212 | transcription regulatory region DNA binding | IDA | molecular_function |
| GO:0031625 | ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0010941 | regulation of cell death | IDA | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0045892 | negative regulation of transcription, DNA-dependen | IDA | biological_process |