Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ZIC1_HUMAN
Description:Zic family member 1 [Source:HGNC Symbol;Acc:12872]
Location:chr3 q24
Node attribute:TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T15PAIGVtTFGASHPRD
S247CNKTFsTMHELzf-C2H2PhosphoSitePlus
T245KSCNKtFSTMHzf-C2H2PhosphoSitePlus
T327HKRTHtGEKPFPhosphoSitePlus
T325KIHKRtHTGEKzf-C2H2PhosphoSitePlus
S20TTFGAsRHHSAHPRD

Dephosphorylation site
ZIC1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000282928K333NBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000282928S346GBIOMARTBrain Cancer21930507, 21930502
ENSP00000282928S399CTCGAOvarian Cancer21720365, 18772890
ENSP00000282928E337QCOSMICHead and Neck Cancer21798893
ENSP00000282928Q8ECOSMICHead and Neck Cancer21798893
ENSP00000282928D4NCOSMICHead and Neck Cancer21798893
ENSP00000282928S399CCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000282928Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 21 hour)cell lineDown0.2115169874

Hyperphosphorylation site
ZIC1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZIC1_HUMANAPOE_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
ZIC1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0008589regulation of smoothened signaling pathwayIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0042472inner ear morphogenesisISSbiological_process
GO:0007610behaviorIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorISSmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0005622intracellularIEAcellular_component
GO:0008270zinc ion bindingIEAmolecular_function
GO:0042307positive regulation of protein import into nucleusIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0007389pattern specification processISSbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0030154cell differentiationIEAbiological_process
GO:0007417central nervous system developmentIEAbiological_process
GO:0008589regulation of smoothened signaling pathwayISSbiological_process
GO:0007389pattern specification processIEAbiological_process
GO:0007610behaviorISSbiological_process
GO:0042307positive regulation of protein import into nucleusISSbiological_process
GO:0045893positive regulation of transcription, DNA-dependenISSbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0007420brain developmentIDAbiological_process
GO:0021510spinal cord developmentIEAbiological_process
GO:0005737cytoplasmIEAcellular_component


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