| UniProt/SwissProt ID: | ZFX_HUMAN |
| Description: | zinc finger protein, X-linked [Source:HGNC Symbol;Acc:12869] |
| Location: | chrX p22.11 |
| Node attribute: | TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T714 | ILSVHtKDLPF | HPRD; phosphoELM | |
| S274 | VDIVEsEPEND | HPRD; phosphoELM; SysPTM | |
| T268 | DDLGGtVDIVE | HPRD; phosphoELM | |
| S543 | LLAVHsKNFPH | PhosphoSitePlus; HPRD | |
| S274 | VDIVEsEPEND | Zfx_Zfy_act | PhosphoSitePlus; SysPTM |
| Y425 | HPLTVyPCMIC | zf-C2H2 | PhosphoSitePlus |
| Y580 | PYQCQyCEYRS | zf-C2H2 | PhosphoSitePlus |
| T771 | VISIHtKDYPH | PhosphoSitePlus; HPRD | |
| T571 | HMRIHtGEKPY | PhosphoSitePlus | |
| T268 | DDLGGtVDIVE | Zfx_Zfy_act | PhosphoSitePlus |
| T657 | IISVHtKDYPH | HPRD | |
| Dephosphorylation site |
| ZFX_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000368475 | N314S | COSMIC | Ovarian Cancer | 21720365 | ENSP00000368475 | V328I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000304985 | N314S | COSMIC | Ovarian Cancer | 21720365 | ENSP00000368486 | N314S | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000304985 | N314S | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000368475 | N314S | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000304985 | V328I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000368475 | V328I | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000304985 | V328I | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000368486 | V328I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000368486 | N314S | COSMIC | Ovarian Cancer | 21720365 | ENSP00000368486 | V328I | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| ZFX_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ZFX_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZFX_HUMAN | U627C_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| ZFX_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0003713 | transcription coactivator activity | TAS | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |