| UniProt/SwissProt ID: | ZFHX3_HUMAN |
| Description: | zinc finger homeobox 3 [Source:HGNC Symbol;Acc:777] |
| Location: | chr16 q22.3 |
| Node attribute: | TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S267 | NNVDLsKFDGF | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S3007 | KKSKLsMAKHF | PhosphoSitePlus | |
| S1146 | IRRCPsTDPEE | PhosphoSitePlus | |
| S2867 | ATETKsSSAPN | PhosphoSitePlus | |
| S571 | RRNRLsFNSEG | PhosphoSitePlus; HPRD; SysPTM | |
| S3677 | SDGPAsPVEGP | PhosphoSitePlus | |
| S425 | LGPLAsSPTKS | HPRD | |
| S1204 | PGSSEsPLSSK | PhosphoSitePlus; HPRD; phosphoELM | |
| S1721 | ADMIAsRQQQQ | PhosphoSitePlus | |
| S426 | GPLASsPTKSS | HPRD | |
| T1945 | ARGNAtKALLE | PhosphoSitePlus | |
| S3446 | EPEAEsKSADS | PhosphoSitePlus | |
| T2865 | GIATEtKSSSA | PhosphoSitePlus | |
| S529 | ALSNQsISNSP | PhosphoSitePlus; HPRD | |
| T796 | GAPSPtKPKTK | PhosphoSitePlus | |
| T2724 | LFKAKtALEAH | PhosphoSitePlus | |
| S3672 | DLSQKsDGPAS | PhosphoSitePlus | |
| T2633 | ENDSGtGGEEP | PhosphoSitePlus | |
| S1117 | HQRSEsLRKLQ | PhosphoSitePlus | |
| S1115 | MKHQRsESLRK | PhosphoSitePlus | |
| S1180 | GGASSsQAEKE | PhosphoSitePlus; HPRD; phosphoELM | |
| S2169 | FDINNsPSEEQ | HPRD | |
| S1197 | TSKRIsFPGSS | PhosphoSitePlus; HPRD; phosphoELM | |
| T2443 | AQPNQtQEKQG | PhosphoSitePlus | |
| S2207 | QRNKDsPYNFS | HPRD; phosphoELM | |
| S1930 | GGSEPsMLPPR | PhosphoSitePlus | |
| S3418 | DPAKEsPKPEE | PhosphoSitePlus; HPRD | |
| S1589 | QPEPTsSPDNK | HPRD; phosphoELM | |
| S2625 | EKASAsPGEND | HPRD | |
| S323 | SNKNIsAIIQG | PhosphoSitePlus | |
| S2182 | EMADKsGLPQK | Homeobox | PhosphoSitePlus |
| S2169 | FDINNsPSEEQ | Homeobox | PhosphoSitePlus |
| T1588 | GQPEPtSSPDN | HPRD; phosphoELM | |
| S1938 | PPRIAsDARGN | PhosphoSitePlus | |
| S3448 | EAESKsADSLY | PhosphoSitePlus | |
| T1147 | RRCPStDPEEA | PhosphoSitePlus | |
| S2868 | TETKSsSAPNE | PhosphoSitePlus | |
| Y2209 | NKDSPyNFSNP | HPRD; phosphoELM | |
| T2217 | SNPPItSLEEL | PhosphoSitePlus | |
| Y293 | KLSFGyVRSFV | PhosphoSitePlus | |
| S1247 | AMTQHsVQPML | PhosphoSitePlus; HPRD | |
| S526 | KDLALsNQSIS | HPRD | |
| S794 | SCGAPsPTKPK | PhosphoSitePlus | |
| S1201 | ISFPGsSESPL | HPRD | |
| S1208 | ESPLSsKRPKT | HPRD | |
| S3409 | PPGAPsPDKDP | PhosphoSitePlus; HPRD | |
| S1590 | PEPTSsPDNKP | HPRD; phosphoELM | |
| S2623 | LEEKAsASPGE | HPRD | |
| S533 | QSISNsPLMPN | PhosphoSitePlus; HPRD | |
| T2876 | PNEGLtKAAMM | PhosphoSitePlus | |
| S2218 | NPPITsLEELK | PhosphoSitePlus | |
| S2437 | LAEAPsAQPNQ | PhosphoSitePlus; HPRD | |
| S1927 | APGGGsEPSML | PhosphoSitePlus | |
| Dephosphorylation site |
| ZFHX3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000268489 | P2650S | COSMIC | Skin Cancer | 21984974 | ENSP00000268489 | L2726F | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000268489 | E593* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000268489 | L3126R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000268489 | Q2952E | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000268489 | P105L | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000268489 | P1595L | COSMIC | Skin Cancer | 21984974 | ENSP00000268489 | Q1762* | COSMIC | Melanoma | 21499247 | ENSP00000268489 | P3213Q | COSMIC | Ovarian Cancer | 21720365 | ENSP00000268489 | S3432T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000268489 | L2350R | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
| Differential expressed protein |
| ZFHX3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ZFHX3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZFHX3_HUMAN | FETA_HUMAN | TF -> target gene | TRANSFAC |
| ZFHX3_HUMAN | AMPN_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| ZFHX3_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007010 | cytoskeleton organization | IEA | biological_process |
| GO:0005667 | transcription factor complex | IDA | cellular_component |
| GO:0006366 | transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0000122 | negative regulation of transcription from RNA poly | IGI | biological_process |
| GO:0019899 | enzyme binding | IPI | molecular_function |
| GO:0003779 | actin binding | IEA | molecular_function |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0045892 | negative regulation of transcription, DNA-dependen | IDA | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | NAS | molecular_function |
| GO:0003705 | RNA polymerase II distal enhancer sequence-specifi | TAS | molecular_function |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0005634 | nucleus | TAS | cellular_component |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | TAS | biological_process |
| GO:0007517 | muscle organ development | IEA | biological_process |
| GO:0003924 | GTPase activity | IEA | molecular_function |
| GO:0005739 | mitochondrion | IEA | cellular_component |
| GO:0045662 | negative regulation of myoblast differentiation | IDA | biological_process |
| GO:0044212 | transcription regulatory region DNA binding | IDA | molecular_function |
| GO:0045663 | positive regulation of myoblast differentiation | IDA | biological_process |