Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ZFHX3_HUMAN
Description:zinc finger homeobox 3 [Source:HGNC Symbol;Acc:777]
Location:chr16 q22.3
Node attribute:TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S267NNVDLsKFDGFPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S3007KKSKLsMAKHFPhosphoSitePlus
S1146IRRCPsTDPEEPhosphoSitePlus
S2867ATETKsSSAPNPhosphoSitePlus
S571RRNRLsFNSEGPhosphoSitePlus; HPRD; SysPTM
S3677SDGPAsPVEGPPhosphoSitePlus
S425LGPLAsSPTKSHPRD
S1204PGSSEsPLSSKPhosphoSitePlus; HPRD; phosphoELM
S1721ADMIAsRQQQQPhosphoSitePlus
S426GPLASsPTKSSHPRD
T1945ARGNAtKALLEPhosphoSitePlus
S3446EPEAEsKSADSPhosphoSitePlus
T2865GIATEtKSSSAPhosphoSitePlus
S529ALSNQsISNSPPhosphoSitePlus; HPRD
T796GAPSPtKPKTKPhosphoSitePlus
T2724LFKAKtALEAHPhosphoSitePlus
S3672DLSQKsDGPASPhosphoSitePlus
T2633ENDSGtGGEEPPhosphoSitePlus
S1117HQRSEsLRKLQPhosphoSitePlus
S1115MKHQRsESLRKPhosphoSitePlus
S1180GGASSsQAEKEPhosphoSitePlus; HPRD; phosphoELM
S2169FDINNsPSEEQHPRD
S1197TSKRIsFPGSSPhosphoSitePlus; HPRD; phosphoELM
T2443AQPNQtQEKQGPhosphoSitePlus
S2207QRNKDsPYNFSHPRD; phosphoELM
S1930GGSEPsMLPPRPhosphoSitePlus
S3418DPAKEsPKPEEPhosphoSitePlus; HPRD
S1589QPEPTsSPDNKHPRD; phosphoELM
S2625EKASAsPGENDHPRD
S323SNKNIsAIIQGPhosphoSitePlus
S2182EMADKsGLPQKHomeoboxPhosphoSitePlus
S2169FDINNsPSEEQHomeoboxPhosphoSitePlus
T1588GQPEPtSSPDNHPRD; phosphoELM
S1938PPRIAsDARGNPhosphoSitePlus
S3448EAESKsADSLYPhosphoSitePlus
T1147RRCPStDPEEAPhosphoSitePlus
S2868TETKSsSAPNEPhosphoSitePlus
Y2209NKDSPyNFSNPHPRD; phosphoELM
T2217SNPPItSLEELPhosphoSitePlus
Y293KLSFGyVRSFVPhosphoSitePlus
S1247AMTQHsVQPMLPhosphoSitePlus; HPRD
S526KDLALsNQSISHPRD
S794SCGAPsPTKPKPhosphoSitePlus
S1201ISFPGsSESPLHPRD
S1208ESPLSsKRPKTHPRD
S3409PPGAPsPDKDPPhosphoSitePlus; HPRD
S1590PEPTSsPDNKPHPRD; phosphoELM
S2623LEEKAsASPGEHPRD
S533QSISNsPLMPNPhosphoSitePlus; HPRD
T2876PNEGLtKAAMMPhosphoSitePlus
S2218NPPITsLEELKPhosphoSitePlus
S2437LAEAPsAQPNQPhosphoSitePlus; HPRD
S1927APGGGsEPSMLPhosphoSitePlus

Dephosphorylation site
ZFHX3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000268489P2650SCOSMICSkin Cancer21984974
ENSP00000268489L2726FBIOMARTBreast Cancer21930507, 21930502
ENSP00000268489E593*COSMICOvarian Cancer21720365
ENSP00000268489L3126RCOSMICOvarian Cancer21720365
ENSP00000268489Q2952EBIOMARTBreast Cancer21930507, 21930502
ENSP00000268489P105LCOSMICHead and Neck Cancer21798893
ENSP00000268489P1595LCOSMICSkin Cancer21984974
ENSP00000268489Q1762*COSMICMelanoma21499247
ENSP00000268489P3213QCOSMICOvarian Cancer21720365
ENSP00000268489S3432TCOSMICOvarian Cancer21720365
ENSP00000268489L2350RBIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
ZFHX3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ZFHX3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZFHX3_HUMANFETA_HUMANTF -> target geneTRANSFAC
ZFHX3_HUMANAMPN_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
ZFHX3_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007010cytoskeleton organizationIEAbiological_process
GO:0005667transcription factor complexIDAcellular_component
GO:0006366transcription from RNA polymerase II promoterTASbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0005525GTP bindingIEAmolecular_function
GO:0000122negative regulation of transcription from RNA polyIGIbiological_process
GO:0019899enzyme bindingIPImolecular_function
GO:0003779actin bindingIEAmolecular_function
GO:0008270zinc ion bindingIEAmolecular_function
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0003700sequence-specific DNA binding transcription factorNASmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specifiTASmolecular_function
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0005622intracellularIEAcellular_component
GO:0005634nucleusTAScellular_component
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentTASbiological_process
GO:0007517muscle organ developmentIEAbiological_process
GO:0003924GTPase activityIEAmolecular_function
GO:0005739mitochondrionIEAcellular_component
GO:0045662negative regulation of myoblast differentiationIDAbiological_process
GO:0044212transcription regulatory region DNA bindingIDAmolecular_function
GO:0045663positive regulation of myoblast differentiationIDAbiological_process


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23