| UniProt/SwissProt ID: | AMPN_HUMAN |
| Description: | alanyl (membrane) aminopeptidase [Source:HGNC Symbol;Acc:500] |
| Location: | chr15 q26.1 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T934 | GFGSGtRALEQ | PhosphoSitePlus | |
| S124 | VIIIHsKKLNY | Peptidase_M1 | PhosphoSitePlus |
| T928 | KDNEEtGFGSG | HPRD | |
| Y582 | PSEFNyVWIVP | PhosphoSitePlus | |
| S932 | ETGFGsGTRAL | PhosphoSitePlus | |
| T589 | WIVPItSIRDG | PhosphoSitePlus | |
| S590 | IVPITsIRDGR | PhosphoSitePlus | |
| Dephosphorylation site |
| AMPN_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000300060 | S415F | COSMIC | Skin Cancer | 21984974 | ENSP00000300060 | P766S | COSMIC | Ovarian Cancer | 21720365 | ENSP00000300060 | P371L | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000300060 | P95S | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000300060 | Hepatocellular Carcinoma | Metastasis | cell line | Up | 2.2 | 19016532 | ENSP00000300060 | Gastric Cancer | Normal vs. Cancer | tissue | Down | 0.22 | 19330469 | ENSP00000300060 | Breast Cancer | Metastasis | cell line | Down | 18729497 | ENSP00000300060 | Breast Cancer | Metastasis | cell line | Down | 18729497 | ENSP00000300060 | Breast Cancer | Normal vs. Cancer | cell line | Down | 0.47 | 20543960 | ENSP00000300060 | Breast Cancer | Normal vs. Cancer | cell line | Down | 0.53 | 20543960 | ENSP00000300060 | Breast Cancer | Normal vs. Cancer | cell line | Down | 0.55 | 20543960 | ENSP00000300060 | Breast Cancer | Normal vs. Cancer | tissue | Down | 0.84 | 20739354 | ENSP00000300060 | Breast Cancer | Normal vs. Cancer | tissue | Down | 0.84 | 20739354 | ENSP00000300060 | Renal Cancer | Normal vs. Cancer | tissue | Down | 19164279 |
| Hyperphosphorylation site |
| AMPN_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZFHX3_HUMAN | AMPN_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| AMPN_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0019048 | virus-host interaction | IEA | biological_process |
| GO:0005829 | cytosol | IEA | cellular_component |
| GO:0006508 | proteolysis | IEA | biological_process |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0009897 | external side of plasma membrane | IEA | cellular_component |
| GO:0005793 | endoplasmic reticulum-Golgi intermediate compartme | IDA | cellular_component |
| GO:0004222 | metalloendopeptidase activity | IEA | molecular_function |
| GO:0008237 | metallopeptidase activity | TAS | molecular_function |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0004872 | receptor activity | TAS | molecular_function |
| GO:0004177 | aminopeptidase activity | IEA | molecular_function |
| GO:0001525 | angiogenesis | IEA | biological_process |
| GO:0030154 | cell differentiation | IEA | biological_process |