| UniProt/SwissProt ID: | ZCHC2_HUMAN |
| Description: | zinc finger, CCHC domain containing 2 [Source:HGNC Symbol;Acc:22916] |
| Location: | chr18 q21.33 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S767 | RESANsTPVGI | PhosphoSitePlus | |
| S493 | DSSEAsSQEED | PhosphoSitePlus; HPRD | |
| S571 | EKRSLsSINKK | PhosphoSitePlus | |
| S236 | AEKDGsGPEGG | PhosphoSitePlus | |
| S494 | SSEASsQEEDV | PhosphoSitePlus; HPRD | |
| S479 | SSLKTsKILEH | PhosphoSitePlus | |
| S463 | FQSISsDSLHS | PhosphoSitePlus | |
| S444 | QLFSSsSQAFL | PhosphoSitePlus | |
| S1150 | DCKQSsMEANQ | PhosphoSitePlus | |
| S623 | NLDIGsGHDTC | PhosphoSitePlus | |
| S273 | LHPAFsFHQRV | PhosphoSitePlus | |
| T605 | GIRLStPQHAH | PhosphoSitePlus | |
| T1173 | PPSNDtLDSAD | PhosphoSitePlus | |
| T1158 | ANQQGtYRLRY | PhosphoSitePlus | |
| S462 | FFQSIsSDSLH | PhosphoSitePlus | |
| S652 | RESFEsEEEKD | HPRD | |
| S182 | LALLGsENREA | PhosphoSitePlus | |
| Y1159 | NQQGTyRLRYA | PhosphoSitePlus | |
| Y176 | SRLIVyLALLG | PhosphoSitePlus | |
| S604 | NGIRLsTPQHA | PhosphoSitePlus | |
| Y1163 | TYRLRyAPPLP | PhosphoSitePlus | |
| S490 | LKEDSsEASSQ | PhosphoSitePlus; HPRD | |
| S489 | HLKEDsSEASS | PhosphoSitePlus; HPRD | |
| S649 | HDGREsFESEE | HPRD | |
| Dephosphorylation site |
| ZCHC2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000269499 | C1021F | COSMIC | Prostate Cancer | 20668451 | ENSP00000269499 | E648Q | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000269499 | G1025* | COSMIC | Lung Cancer | 20668451 | ENSP00000269499 | N618D | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000269499 | Q952E | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
| Differential expressed protein |
| ZCHC2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ZCHC2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ANPRB_HUMAN | ZCHC2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| ZCHC2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0007154 | cell communication | IEA | biological_process |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0035091 | phosphatidylinositol binding | IEA | molecular_function |
| GO:0008270 | zinc ion binding | IEA | molecular_function |