Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ZCHC2_HUMAN
Description:zinc finger, CCHC domain containing 2 [Source:HGNC Symbol;Acc:22916]
Location:chr18 q21.33
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S767RESANsTPVGIPhosphoSitePlus
S493DSSEAsSQEEDPhosphoSitePlus; HPRD
S571EKRSLsSINKKPhosphoSitePlus
S236AEKDGsGPEGGPhosphoSitePlus
S494SSEASsQEEDVPhosphoSitePlus; HPRD
S479SSLKTsKILEHPhosphoSitePlus
S463FQSISsDSLHSPhosphoSitePlus
S444QLFSSsSQAFLPhosphoSitePlus
S1150DCKQSsMEANQPhosphoSitePlus
S623NLDIGsGHDTCPhosphoSitePlus
S273LHPAFsFHQRVPhosphoSitePlus
T605GIRLStPQHAHPhosphoSitePlus
T1173PPSNDtLDSADPhosphoSitePlus
T1158ANQQGtYRLRYPhosphoSitePlus
S462FFQSIsSDSLHPhosphoSitePlus
S652RESFEsEEEKDHPRD
S182LALLGsENREAPhosphoSitePlus
Y1159NQQGTyRLRYAPhosphoSitePlus
Y176SRLIVyLALLGPhosphoSitePlus
S604NGIRLsTPQHAPhosphoSitePlus
Y1163TYRLRyAPPLPPhosphoSitePlus
S490LKEDSsEASSQPhosphoSitePlus; HPRD
S489HLKEDsSEASSPhosphoSitePlus; HPRD
S649HDGREsFESEEHPRD

Dephosphorylation site
ZCHC2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000269499C1021FCOSMICProstate Cancer20668451
ENSP00000269499E648QCOSMICHead and Neck Cancer21798893
ENSP00000269499G1025*COSMICLung Cancer20668451
ENSP00000269499N618DBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000269499Q952EBIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
ZCHC2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ZCHC2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ANPRB_HUMANZCHC2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
ZCHC2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0007154cell communicationIEAbiological_process
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0035091phosphatidylinositol bindingIEAmolecular_function
GO:0008270zinc ion bindingIEAmolecular_function


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