Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:XRCC6_HUMAN
Description:X-ray repair complementing defective repair in Chinese hamster cells 6 [Source:HGNC Symbol;Acc:4055]
Location:chr22 q13.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T455EKIMAtPEQVGHPRD
T455EKIMAtPEQVGKuPhosphoSitePlus
S592AYGLKsGLKKQSAP; SAP30_Sin3_bdgPhosphoSitePlus
T292KLYREtNEPVKHPRD
S180PHGNDsAKASRKu_NPhosphoSitePlus
Y530FKELVyPPDYNKu_CPhosphoSitePlus
T170RIMLFtNEDNPHPRD
S550HDNEGsGSKRPKu_CPhosphoSitePlus
S306RTFNTsTGGLLKuPhosphoSitePlus
S27ENLEAsGDYKYPhosphoSitePlus; HPRD
S2____MsGWESYPhosphoSitePlus
T541PEGKVtKRKHDKu_CPhosphoSitePlus
S324SQIYGsRQIILKuPhosphoSitePlus
S552NEGSGsKRPKVHPRD
T577TLGKFtVPMLKHPRD
S550HDNEGsGSKRPHPRD
S37YSGRDsLIFLVHPRD; phosphoELM
S6YKTEHPRD; phosphoELM
S477TYRSDsFENPVKu_CPhosphoSitePlus
S6MSGWEsYYKTEPhosphoSitePlus
Y588EACRAyGLKSGSAP; SAP30_Sin3_bdgPhosphoSitePlus
S51KAMFEsQSEDEKu_NPhosphoSitePlus
S222YRDIIsIAEDEphosphoELM
S222YRDIIsIAEDEKu_NPhosphoSitePlus
Y8GWESYyKTEGDPhosphoSitePlus
T292KLYREtNEPVKKuPhosphoSitePlus
Y7SGWESyYKTEGPhosphoSitePlus
Y534VYPPDyNPEGKKu_CPhosphoSitePlus
S306RTFNTsTGGLLHPRD
T577TLGKFtVPMLKSAP; SAP30_Sin3_bdgPhosphoSitePlus
S520NKRLGsLVDEFKu_CPhosphoSitePlus
Y103NFKNIyVLQELKu_NPhosphoSitePlus
S155CANLFsDVQFKKu_NPhosphoSitePlus
T604LLEALtKHFQDSAP; SAP30_Sin3_bdgPhosphoSitePlus
T307TFNTStGGLLLHPRD

Dephosphorylation site
XRCC6_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000384257E418DTCGAOvarian Cancer21720365, 18772890
ENSP00000384257E418DCOSMICOvarian Cancer21720365
ENSP00000353192I387LCOSMICLung Cancer20668451
ENSP00000384257I387LCOSMICLung Cancer20668451
ENSP00000353192E418DTCGAOvarian Cancer21720365, 18772890
ENSP00000353192E418DCOSMICOvarian Cancer21720365
ENSP00000352257E418DTCGAOvarian Cancer21720365, 18772890
ENSP00000352257I387LCOSMICLung Cancer20668451
ENSP00000352257I267VBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000384257D195HCOSMICHead and Neck Cancer21798893
ENSP00000352257D195HCOSMICHead and Neck Cancer21798893
ENSP00000352257E418DCOSMICOvarian Cancer21720365
ENSP00000353192D195HCOSMICHead and Neck Cancer21798893

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000384257Gastric CancerMetastasiscell lineUp1.617022644
ENSP00000384257Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000384257Breast CancerNormal vs. Cancercell lineUp517022634
ENSP00000384257Gastric CancerMetastasiscell lineUp1.617022644

Hyperphosphorylation site
XRCC6_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANXRCC6_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03450Non-homologous end-joining

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045944positive regulation of transcription from RNA polyIMPbiological_process
GO:0016020membraneTAScellular_component
GO:0050769positive regulation of neurogenesisIEAbiological_process
GO:0033151V(D)J recombinationIEAbiological_process
GO:0006281DNA repairTASbiological_process
GO:0006302double-strand break repairTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0070419nonhomologous end joining complexIDAcellular_component
GO:0043564Ku70:Ku80 complexIDAcellular_component
GO:0006974response to DNA damage stimulusIEAbiological_process
GO:0006266DNA ligationTASbiological_process
GO:0042162telomeric DNA bindingIEAmolecular_function
GO:0005667transcription factor complexIDAcellular_component
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0005634nucleusTAScellular_component
GO:0005634nucleusIEAcellular_component
GO:0003691double-stranded telomeric DNA bindingIDAmolecular_function
GO:0006302double-strand break repairIEAbiological_process
GO:0016032viral reproductionTASbiological_process
GO:00515755'-deoxyribose-5-phosphate lyase activityIMPmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0006303double-strand break repair via nonhomologous end jIEAbiological_process
GO:0044212transcription regulatory region DNA bindingIDAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0005958DNA-dependent protein kinase-DNA ligase 4 complexIEAcellular_component
GO:0045892negative regulation of transcription, DNA-dependenIMPbiological_process
GO:0000783nuclear telomere cap complexTAScellular_component
GO:0010212response to ionizing radiationIEAbiological_process
GO:0003690double-stranded DNA bindingTASmolecular_function
GO:0003684damaged DNA bindingIEAmolecular_function
GO:0000723telomere maintenanceTASbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0008022protein C-terminus bindingIPImolecular_function
GO:0004003ATP-dependent DNA helicase activityIEAmolecular_function