Phosphorylation

Protein information

Protein summary

Phosphorylation site

Dephosphorylation site

Mutation site

Differential expressed protein

Hyperphosphorylation site

Direct interaction pair

Function Annotation

Protein Summary

UniProt/SwissProt ID:	WNT1_HUMAN
Description:	wingless-type MMTV integration site family, member 1 [Source:HGNC Symbol;Acc:12774]
Location:	chr12 q13.12
Node attribute:	ligand

Phosphorylation site

Position	PhosphoPeptide	Catalytic kinase	Source
S144	VARSCsEGSIE	wnt	PhosphoSitePlus
S132	IFAITsAGVTH	wnt	PhosphoSitePlus
T136	TSAGVtHSVAR	wnt	PhosphoSitePlus

Dephosphorylation site

WNT1_HUMAN do not have dephosphorylation site.

Mutation site

WNT1_HUMAN do not have mutation site.

Differential expressed protein

WNT1_HUMAN is not differential expressed protein.

Hyperphosphorylation site

WNT1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair

Source	Target	Relationship	Resource
WNT1_HUMAN	FZD9_HUMAN	ligand -> receptor	HPMR

Function Annotation

KEGG Pathway

KEGG ID	Pathway
hsa05200	Pathways in cancer
hsa05217	Basal cell carcinoma
hsa04310	Wnt signaling pathway
hsa04340	Hedgehog signaling pathway
hsa05166	HTLV-I infection
hsa04916	Melanogenesis

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0035284	brain segmentation	IBA	biological_process
GO:0045944	positive regulation of transcription from RNA poly	IEA	biological_process
GO:0033077	T cell differentiation in thymus	IEA	biological_process
GO:0030579	ubiquitin-dependent SMAD protein catabolic process	IEA	biological_process
GO:0001934	positive regulation of protein phosphorylation	IEA	biological_process
GO:0042472	inner ear morphogenesis	IBA	biological_process
GO:0044212	transcription regulatory region DNA binding	IDA	molecular_function
GO:0043568	positive regulation of insulin-like growth factor	IDA	biological_process
GO:0044336	canonical Wnt receptor signaling pathway involved	IMP	biological_process
GO:0030901	midbrain development	ISS	biological_process
GO:0051091	positive regulation of sequence-specific DNA bindi	ISS	biological_process
GO:0060061	Spemann organizer formation	ISS	biological_process
GO:0005125	cytokine activity	IEA	molecular_function
GO:0000578	embryonic axis specification	ISS	biological_process
GO:0048664	neuron fate determination	IBA	biological_process
GO:0090344	negative regulation of cell aging	IDA	biological_process
GO:0014902	myotube differentiation	IEA	biological_process
GO:0045893	positive regulation of transcription, DNA-dependen	IEA	biological_process
GO:0030512	negative regulation of transforming growth factor	IEA	biological_process
GO:0048663	neuron fate commitment	IEA	biological_process
GO:0007267	cell-cell signaling	ISS	biological_process
GO:0021588	cerebellum formation	IEA	biological_process
GO:0045121	membrane raft	IBA	cellular_component
GO:0042770	signal transduction in response to DNA damage	IDA	biological_process
GO:0010812	negative regulation of cell-substrate adhesion	IDA	biological_process
GO:0000578	embryonic axis specification	IEA	biological_process
GO:0022037	metencephalon development	IEA	biological_process
GO:0045893	positive regulation of transcription, DNA-dependen	ISS	biological_process
GO:0060061	Spemann organizer formation	IEA	biological_process
GO:0009611	response to wounding	IEP	biological_process
GO:0019904	protein domain specific binding	IEA	molecular_function
GO:0005886	plasma membrane	IBA	cellular_component
GO:0071375	cellular response to peptide hormone stimulus	IEA	biological_process
GO:0010592	positive regulation of lamellipodium assembly	IMP	biological_process
GO:0060070	canonical Wnt receptor signaling pathway	IEA	biological_process
GO:0022004	midbrain-hindbrain boundary maturation during brai	IEA	biological_process
GO:0005110	frizzled-2 binding	IBA	molecular_function
GO:0022004	midbrain-hindbrain boundary maturation during brai	IBA	biological_process
GO:0021527	spinal cord association neuron differentiation	IEA	biological_process
GO:0048664	neuron fate determination	IEA	biological_process
GO:0001658	branching involved in ureteric bud morphogenesis	IEA	biological_process
GO:0045747	positive regulation of Notch signaling pathway	IDA	biological_process
GO:0005615	extracellular space	IBA	cellular_component
GO:0071425	hematopoietic stem cell proliferation	IBA	biological_process
GO:0016055	Wnt receptor signaling pathway	IEA	biological_process
GO:0021588	cerebellum formation	ISS	biological_process
GO:0031100	organ regeneration	IEA	biological_process
GO:0005515	protein binding	IPI	molecular_function
GO:0042472	inner ear morphogenesis	IEA	biological_process
GO:0048332	mesoderm morphogenesis	IBA	biological_process
GO:0030901	midbrain development	IEA	biological_process
GO:0005125	cytokine activity	ISS	molecular_function
GO:0070365	hepatocyte differentiation	IEA	biological_process
GO:0021536	diencephalon development	IEA	biological_process
GO:0005515	protein binding	IEA	molecular_function
GO:0048146	positive regulation of fibroblast proliferation	IMP	biological_process
GO:0021536	diencephalon development	IBA	biological_process
GO:0005737	cytoplasm	IDA	cellular_component
GO:0008284	positive regulation of cell proliferation	IEA	biological_process
GO:0007520	myoblast fusion	IEA	biological_process
GO:0009986	cell surface	IEA	cellular_component
GO:0021797	forebrain anterior/posterior pattern specification	IEA	biological_process
GO:0033077	T cell differentiation in thymus	IBA	biological_process
GO:0021551	central nervous system morphogenesis	ISS	biological_process
GO:0005102	receptor binding	IEA	molecular_function
GO:0005770	late endosome	IBA	cellular_component
GO:0005576	extracellular region	IEA	cellular_component
GO:0070365	hepatocyte differentiation	IBA	biological_process
GO:0005578	proteinaceous extracellular matrix	IEA	cellular_component
GO:0048018	receptor agonist activity	IC	molecular_function
GO:0022408	negative regulation of cell-cell adhesion	IMP	biological_process
GO:0005769	early endosome	IBA	cellular_component
GO:0007275	multicellular organismal development	IEA	biological_process
GO:0021587	cerebellum morphogenesis	IBA	biological_process
GO:0005109	frizzled binding	IC	molecular_function
GO:0021551	central nervous system morphogenesis	IEA	biological_process
GO:0030917	midbrain-hindbrain boundary development	IEA	biological_process
GO:0043066	negative regulation of apoptotic process	IMP	biological_process
GO:0009798	axis specification	IBA	biological_process
GO:2000059	negative regulation of protein ubiquitination invo	IEA	biological_process
GO:0021592	fourth ventricle development	IBA	biological_process
GO:0051091	positive regulation of sequence-specific DNA bindi	IEA	biological_process
GO:0045599	negative regulation of fat cell differentiation	ISS	biological_process
GO:0045599	negative regulation of fat cell differentiation	IEA	biological_process
GO:0060070	canonical Wnt receptor signaling pathway	IMP	biological_process
GO:0009880	embryonic pattern specification	IBA	biological_process
GO:0008284	positive regulation of cell proliferation	IDA	biological_process
GO:2000002	negative regulation of DNA damage checkpoint	IDA	biological_process
GO:0061184	positive regulation of dermatome development	IDA	biological_process
GO:0071425	hematopoietic stem cell proliferation	IEA	biological_process
GO:0007223	Wnt receptor signaling pathway, calcium modulating	IBA	biological_process
GO:0016055	Wnt receptor signaling pathway	IDA	biological_process
GO:0021797	forebrain anterior/posterior pattern specification	IBA	biological_process
GO:0007267	cell-cell signaling	IEA	biological_process

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network