| UniProt/SwissProt ID: | WASL_HUMAN |
| Description: | Wiskott-Aldrich syndrome-like [Source:HGNC Symbol;Acc:12735] |
| Location: | chr7 q31.32 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y255 | ETSKViYDFIE | HPRD | |
| T460 | ESTPPtPAPTS | PhosphoSitePlus | |
| T457 | DGQEStPPTPA | PhosphoSitePlus | |
| Y256 | TSKVIyDFIEK | ABL1 | HPRD; RegPhos; SysPTM |
| T464 | PTPAPtSGIVG | PhosphoSitePlus | |
| Y100 | YNNFVyNSPRG | WH1 | PhosphoSitePlus |
| Y95 | WEQELyNNFVY | WH1 | PhosphoSitePlus |
| T135 | FRKAVtDLLGR | WH1 | PhosphoSitePlus |
| S484 | SKAIHsSDEDE | PhosphoSitePlus; HPRD; phosphoELM | |
| S485 | KAIHSsDEDED | PhosphoSitePlus; HPRD; phosphoELM | |
| Y175 | TTNRFyGPQVN | PhosphoSitePlus | |
| Y175 | TTNRFyGPQVN | ABL1 | HPRD; RegPhos |
| Y256 | TSKVIyDFIEK | phosphoELM; RegPhos; SysPTM | |
| S430 | NSRPVsCSGRD | WH2 | PhosphoSitePlus |
| S58 | RNCMWsKKCSG | WH1 | PhosphoSitePlus |
| Y256 | TSKVIyDFIEK | PBD | PhosphoSitePlus; SysPTM |
| Dephosphorylation site |
| WASL_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000223023 | T135I | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000223023 | R131* | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| WASL_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| WASL_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ABL1_HUMAN | WASL_HUMAN | kinase -> substrate | RegPhos |
| ZAGL2_HUMAN | WASL_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05131 | Shigellosis |
| hsa05100 | Bacterial invasion of epithelial cells |
| hsa04520 | Adherens junction |
| hsa05130 | Pathogenic Escherichia coli infection |
| hsa04062 | Chemokine signaling pathway |
| hsa04810 | Regulation of actin cytoskeleton |
| hsa04666 | Fc gamma R-mediated phagocytosis |
| hsa05132 | Salmonella infection |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016023 | cytoplasmic membrane-bounded vesicle | ISS | cellular_component |
| GO:0030050 | vesicle transport along actin filament | ISS | biological_process |
| GO:0009617 | response to bacterium | IEA | biological_process |
| GO:0005083 | small GTPase regulator activity | IEA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0008154 | actin polymerization or depolymerization | IEA | biological_process |
| GO:0034629 | cellular protein complex localization | IEA | biological_process |
| GO:0050999 | regulation of nitric-oxide synthase activity | TAS | biological_process |
| GO:2000370 | positive regulation of clathrin-mediated endocytos | ISS | biological_process |
| GO:0006461 | protein complex assembly | IEA | biological_process |
| GO:0003779 | actin binding | IEA | molecular_function |
| GO:0016050 | vesicle organization | ISS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0051653 | spindle localization | IEA | biological_process |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0030036 | actin cytoskeleton organization | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0030027 | lamellipodium | IEA | cellular_component |
| GO:0030478 | actin cap | IEA | cellular_component |
| GO:0007411 | axon guidance | TAS | biological_process |
| GO:0015629 | actin cytoskeleton | TAS | cellular_component |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0046209 | nitric oxide metabolic process | TAS | biological_process |
| GO:0006900 | membrane budding | ISS | biological_process |
| GO:0051491 | positive regulation of filopodium assembly | ISS | biological_process |
| GO:0030666 | endocytic vesicle membrane | TAS | cellular_component |
| GO:0006928 | cellular component movement | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |