Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:WASL_HUMAN
Description:Wiskott-Aldrich syndrome-like [Source:HGNC Symbol;Acc:12735]
Location:chr7 q31.32
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y255ETSKViYDFIEHPRD
T460ESTPPtPAPTSPhosphoSitePlus
T457DGQEStPPTPAPhosphoSitePlus
Y256TSKVIyDFIEKABL1HPRD; RegPhos; SysPTM
T464PTPAPtSGIVGPhosphoSitePlus
Y100YNNFVyNSPRGWH1PhosphoSitePlus
Y95WEQELyNNFVYWH1PhosphoSitePlus
T135FRKAVtDLLGRWH1PhosphoSitePlus
S484SKAIHsSDEDEPhosphoSitePlus; HPRD; phosphoELM
S485KAIHSsDEDEDPhosphoSitePlus; HPRD; phosphoELM
Y175TTNRFyGPQVNPhosphoSitePlus
Y175TTNRFyGPQVNABL1HPRD; RegPhos
Y256TSKVIyDFIEKphosphoELM; RegPhos; SysPTM
S430NSRPVsCSGRDWH2PhosphoSitePlus
S58RNCMWsKKCSGWH1PhosphoSitePlus
Y256TSKVIyDFIEKPBDPhosphoSitePlus; SysPTM

Dephosphorylation site
WASL_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000223023T135ICOSMICHead and Neck Cancer21798893
ENSP00000223023R131*COSMICSkin Cancer21984974

Differential expressed protein
WASL_HUMAN is not differential expressed protein.

Hyperphosphorylation site
WASL_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ABL1_HUMANWASL_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANWASL_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05131Shigellosis
hsa05100Bacterial invasion of epithelial cells
hsa04520Adherens junction
hsa05130Pathogenic Escherichia coli infection
hsa04062Chemokine signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa04666Fc gamma R-mediated phagocytosis
hsa05132Salmonella infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016023cytoplasmic membrane-bounded vesicleISScellular_component
GO:0030050vesicle transport along actin filamentISSbiological_process
GO:0009617response to bacteriumIEAbiological_process
GO:0005083small GTPase regulator activityIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0008154actin polymerization or depolymerizationIEAbiological_process
GO:0034629cellular protein complex localizationIEAbiological_process
GO:0050999regulation of nitric-oxide synthase activityTASbiological_process
GO:2000370positive regulation of clathrin-mediated endocytosISSbiological_process
GO:0006461protein complex assemblyIEAbiological_process
GO:0003779actin bindingIEAmolecular_function
GO:0016050vesicle organizationISSbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0051653spindle localizationIEAbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0030036actin cytoskeleton organizationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0030027lamellipodiumIEAcellular_component
GO:0030478actin capIEAcellular_component
GO:0007411axon guidanceTASbiological_process
GO:0015629actin cytoskeletonTAScellular_component
GO:0005829cytosolTAScellular_component
GO:0046209nitric oxide metabolic processTASbiological_process
GO:0006900membrane buddingISSbiological_process
GO:0051491positive regulation of filopodium assemblyISSbiological_process
GO:0030666endocytic vesicle membraneTAScellular_component
GO:0006928cellular component movementTASbiological_process
GO:0005886plasma membraneTAScellular_component


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