Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:VGFR3_HUMAN
Description:fms-related tyrosine kinase 4 [Source:HGNC Symbol;Acc:3767]
Location:chr5 q35.3
Node attribute:kinase; receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y532NVSAMyKCVVSHPRD
Y1333GGQVFyNSEYGHPRD
Y1363FTDNHPRD
T517EGKNKtVSKLVHPRD
Y1230SLAARyYNWVSHPRD
Y1337FYNSEyGELSEHPRD
Y1068YKDPDyVRKGSphosphoELM
Y1063LARDIyKDPDYphosphoELM
Y1265MTPTTyKGSVDHPRD
Y1231LAARYyNWVSFHPRD

Dephosphorylation site
VGFR3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000261937E989QDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000261937A806SDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000261937G571SCOSMICOvarian Cancer21720365
ENSP00000261937Y369*COSMICLung Cancer20668451
ENSP00000261937Y1333HDing2008, COSMICLung Cancer18948947
ENSP00000261937E321DCOSMICBreast Cancer20668451
ENSP00000261937G781SCOSMICLung Cancer20668451
ENSP00000377016S1249FBIOMARTBreast Cancer21930507, 21930502
ENSP00000261937S1249FBIOMARTBreast Cancer21930507, 21930502
ENSP00000261937L32MCOSMICOvarian Cancer21720365
ENSP00000261937R461QCOSMICLung Cancer20668451
ENSP00000261937R82*COSMICHead and Neck Cancer21798893
ENSP00000377016T1010IGreenman2007Skin Cancer17344846, 18428421
ENSP00000261937S637RCOSMICGastric Cancer21097718
ENSP00000261937S1289RDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000377016R378CGreenman2007Renal Cancer17344846, 18428421
ENSP00000261937G377RCOSMICOvarian Cancer20668451

Differential expressed protein
VGFR3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
VGFR3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
VEGFD_HUMANVGFR3_HUMANligand -> receptorHPMR
VGFR3_HUMANSHC1_HUMANkinase -> substrateRegPhos
VEGFD_HUMANVGFR3_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04060Cytokine-cytokine receptor interaction
hsa04510Focal adhesion

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043066negative regulation of apoptotic processIMPbiological_process
GO:0019903protein phosphatase bindingIPImolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0046777protein autophosphorylationIDAbiological_process
GO:0004714transmembrane receptor protein tyrosine kinase actIMPmolecular_function
GO:0007169transmembrane receptor protein tyrosine kinase sigTASbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0090037positive regulation of protein kinase C signaling IMPbiological_process
GO:0038084vascular endothelial growth factor signaling pathwIEAbiological_process
GO:0001945lymph vessel developmentISSbiological_process
GO:0002040sprouting angiogenesisIEAbiological_process
GO:0010575positive regulation vascular endothelial growth faIMPbiological_process
GO:0046330positive regulation of JNK cascadeIMPbiological_process
GO:0048514blood vessel morphogenesisISSbiological_process
GO:0060312regulation of blood vessel remodelingIEAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0001934positive regulation of protein phosphorylationIMPbiological_process
GO:0043410positive regulation of MAPK cascadeIMPbiological_process
GO:0035924cellular response to vascular endothelial growth fIMPbiological_process
GO:0005021vascular endothelial growth factor-activated recepIEAmolecular_function
GO:0001938positive regulation of endothelial cell proliferatIMPbiological_process
GO:0019838growth factor bindingIPImolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0048514blood vessel morphogenesisIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0018108peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0004672protein kinase activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0070374positive regulation of ERK1 and ERK2 cascadeIMPbiological_process
GO:0001945lymph vessel developmentIEAbiological_process
GO:0010595positive regulation of endothelial cell migrationIMPbiological_process
GO:0001944vasculature developmentISSbiological_process
GO:0001946lymphangiogenesisIEAbiological_process
GO:0001944vasculature developmentIEAbiological_process
GO:0048010vascular endothelial growth factor receptor signalIMPbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005887integral to plasma membraneIEAcellular_component
GO:0005576extracellular regionIEAcellular_component


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