Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:VGFR1_HUMAN
Description:fms-related tyrosine kinase 1 [Source:HGNC Symbol;Acc:3763]
Location:chr13 q12.3
Node attribute:substrate; kinase; receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y1333NSVVLySTPPIPhosphoSitePlus
S739TNQKGsVESSAI-setPhosphoSitePlus
T265TRVQMtWSYPDIg_2PhosphoSitePlus
Y1333NSVVLySTPPIFLT1RegPhos
Y1048LARDIyKNPDYHPRD; phosphoELM
S267VQMTWsYPDEKIg_2PhosphoSitePlus
T588LYRDVtWILLRI-setPhosphoSitePlus
T218GHLYKtNYLTHIg_2PhosphoSitePlus
Y1053YKNPDyVRKGDHPRD; phosphoELM
Y1213SDDVRyVNAFKFLT1HPRD; phosphoELM; RegPhos
T599TVNNRtMHYSII-setPhosphoSitePlus
Y1053YKNPDyVRKGDPkinase_TyrPhosphoSitePlus
Y1169QDGKDyIPINAPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1197DFFKEsISAPKPhosphoSitePlus
S1207KFNSGsSDDVRPhosphoSitePlus
Y745VESSAyLTVQGI-setPhosphoSitePlus
Y1327SPPPDyNSVVLautocatalysisRegPhos
T618KEHSItLNLTII-setPhosphoSitePlus
Y1048LARDIyKNPDYPkinase_TyrPhosphoSitePlus
Y794EIKTDyLSIIMDUF4083PhosphoSitePlus
Y911MVIVEyCKYGNPkinase_TyrPhosphoSitePlus
Y1333NSVVLySTPphosphoELM
S743GSVESsAYLTVI-setPhosphoSitePlus
S742KGSVEsSAYLTI-setPhosphoSitePlus
Y1053YKNPDyVRKGDautocatalysis RegPhos
Y1242SMFDDyQGDSSFLT1HPRD; phosphoELM; RegPhos
S631VSLQDsGTYACI-setPhosphoSitePlus
Y920GNLSNyLKSKRPkinase_TyrPhosphoSitePlus
Y388YLTRGySLIIKI-setPhosphoSitePlus
Y1327SPPPDyNSVVLPhosphoSitePlus
T255LNCTAtTPLNTIg_2PhosphoSitePlus
Y1333NSVVLySTPPIautocatalysisRegPhos
S1205APKFNsGSSDDPhosphoSitePlus
T222KTNYLtHRQTNIg_2PhosphoSitePlus
T633LQDSGtYACRAI-setPhosphoSitePlus
Y1327SPPPDyNSVVLFLT1HPRD; phosphoELM; RegPhos
Y1169QDGKDyIPINAautocatalysis RegPhos
Y1213SDDVRyVNAFKautocatalysisRegPhos
Y1333NSVVLySTPFLT1HPRD; phosphoELM
Y815CERLPyDASKWPhosphoSitePlus
Y794EIKTDyLSIIMHPRD; phosphoELM; RegPhos
Y1242SMFDDyQGDSSPhosphoSitePlus
Y383EKSARyLTRGYI-setPhosphoSitePlus
S1199FKESIsAPKFNPhosphoSitePlus
Y1213SDDVRyVNAFKPhosphoSitePlus; phosphoELM
Y1242SMFDDyQGDSSautocatalysisRegPhos

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y1213GSSDDVRyVNAFKFMPTPN11HPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000282397S818NBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000282397K427NBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000282397R781QGreenman2007, HPINeoplasms by Histologic Type16618716, 17344846, 18428421
ENSP00000282397L1061VGreenman2007Other Cancer(urinary_tract cancer)17344846, 18428421
ENSP00000282397L1249MDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000282397L1061VGreenman2007, HPIUrinary Bladder Cancer17344846, 18428421
ENSP00000282397E201QDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000282397L422IGreenman2007, HPILung Cancer16140923, 17344846, 18428421
ENSP00000282397R781QGreenman2007Central Nervous System Neoplasms16618716, 17344846, 18428421
ENSP00000282397A1025EDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502

Differential expressed protein
VGFR1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
VGFR1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
VEGFA_HUMANVGFR1_HUMANligand -> receptorHPMR
VGFR1_HUMANVGFR1_HUMANkinase -> substrateRegPhos
PDPK1_HUMANVGFR1_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANVGFR1_HUMANkinase -> substrateRegPhos
PTN11_HUMANVGFR1_HUMANphosphatase -> substrateHPRD
VEGFA_HUMANVGFR1_HUMANotherKEGG
VEGFB_HUMANVGFR1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05202Transcriptional misregulation in cancer
hsa05323Rheumatoid arthritis
hsa04060Cytokine-cytokine receptor interaction
hsa04144Endocytosis
hsa04510Focal adhesion

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0002040sprouting angiogenesisIEAbiological_process
GO:0005768endosomeIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0001525angiogenesisIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0014068positive regulation of phosphatidylinositol 3-kinaIMPbiological_process
GO:0010863positive regulation of phospholipase C activityIMPbiological_process
GO:0036326VEGF-A-activated receptor activityIDAmolecular_function
GO:0035924cellular response to vascular endothelial growth fIDAbiological_process
GO:0043410positive regulation of MAPK cascadeIDAbiological_process
GO:0016477cell migrationIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0016477cell migrationIMPbiological_process
GO:0048598embryonic morphogenesisIEAbiological_process
GO:0001569patterning of blood vesselsIEAbiological_process
GO:0005794Golgi apparatusIDAcellular_component
GO:0045766positive regulation of angiogenesisIMPbiological_process
GO:0030335positive regulation of cell migrationIDAbiological_process
GO:0043406positive regulation of MAP kinase activityIDAbiological_process
GO:0036332placental growth factor-activated receptor activitIDAmolecular_function
GO:0030154cell differentiationIEAbiological_process
GO:0036323vascular endothelial growth factor receptor-1 signIDAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0004714transmembrane receptor protein tyrosine kinase actTASmolecular_function
GO:0048514blood vessel morphogenesisISSbiological_process
GO:0005021vascular endothelial growth factor-activated recepIMPmolecular_function
GO:0005615extracellular spaceTAScellular_component
GO:0038084vascular endothelial growth factor signaling pathwIEAbiological_process
GO:0048514blood vessel morphogenesisIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0018108peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0042802identical protein bindingIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0019838growth factor bindingIPImolecular_function
GO:0005021vascular endothelial growth factor-activated recepIEAmolecular_function
GO:0030949positive regulation of vascular endothelial growthIDAbiological_process
GO:0043552positive regulation of phosphatidylinositol 3-kinaIMPbiological_process
GO:0036327VEGF-B-activated receptor activityIDAmolecular_function
GO:0048598embryonic morphogenesisISSbiological_process
GO:0002548monocyte chemotaxisIDAbiological_process
GO:0046777protein autophosphorylationIDAbiological_process
GO:0008284positive regulation of cell proliferationTASbiological_process
GO:0005887integral to plasma membraneIDAcellular_component
GO:0007169transmembrane receptor protein tyrosine kinase sigTASbiological_process
GO:0048010vascular endothelial growth factor receptor signalIMPbiological_process