Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:VAV2_HUMAN
Description:vav 2 guanine nucleotide exchange factor [Source:HGNC Symbol;Acc:12658]
Location:chr9 q34.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S779ASRASsRSPASPhosphoSitePlus; phosphoELM
S778SASRAsSRSPAPhosphoSitePlus
S616RGDPEsPWWEGHPRD
Y142NDDDVyRSLEEEGFRHPRD; phosphoELM; RegPhos
S566PCKFTsPADLDHPRD
S781RASSRsPASCAphosphoELM
Y172GGDDIyEDIIKLckphosphoELM; RegPhos
T575PPCKFtSPADLPhosphoSitePlus; phosphoELM
Y159LGEDIyDCVPCLckphosphoELM; RegPhos
Y426TKQDRyLFLFDPHPhosphoSitePlus
Y159LGEDIyDCVPCPhosphoSitePlus
Y142NDDDVyRSLEELckphosphoELM; RegPhos
Y172GGDDIyEDIIKPhosphoSitePlus
S626RGDPEsPWWEGSH3_2PhosphoSitePlus
S771RASSRsPVFTPHPRD
S768SASRAsSRSPVHPRD
T565PPCKFtSPADLHPRD
Y172GGDDIyEDIIKEGFRHPRD; phosphoELM; RegPhos
Y142NDDDVyRSLEEPhosphoSitePlus
Y159LGEDIyDCVPCEGFRHPRD; phosphoELM; RegPhos
S576PCKFTsPADLDPhosphoSitePlus; phosphoELM
S769ASRASsRSPVFHPRD

Dephosphorylation site
VAV2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000385362D101YCOSMICLung Cancer18948947
ENSP00000385362R143LCOSMICLung Cancer18948947
ENSP00000385362Q839*COSMICSkin Cancer21984974
ENSP00000385362T781RCOSMICBreast Cancer20668451
ENSP00000385362N369HCOSMICOvarian Cancer21720365
ENSP00000385362V371FCOSMICOvarian Cancer21720365
ENSP00000385362G168RCOSMICOvarian Cancer21720365
ENSP00000385362A111VCOSMICOvarian Cancer21720365

Differential expressed protein
VAV2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
VAV2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
EGFR_HUMANVAV2_HUMANkinase -> substrateRegPhos
LCK_HUMANVAV2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04650Natural killer cell mediated cytotoxicity
hsa04510Focal adhesion
hsa04062Chemokine signaling pathway
hsa04670Leukocyte transendothelial migration
hsa04660T cell receptor signaling pathway
hsa04810Regulation of actin cytoskeleton

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051056regulation of small GTPase mediated signal transduTASbiological_process
GO:0016477cell migrationIEAbiological_process
GO:0035023regulation of Rho protein signal transductionIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0035556intracellular signal transductionIEAbiological_process
GO:0030032lamellipodium assemblyIEAbiological_process
GO:0005089Rho guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0007165signal transductionTASbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0007264small GTPase mediated signal transductionTASbiological_process
GO:0007264small GTPase mediated signal transductionIEAbiological_process
GO:0005543phospholipid bindingIEAmolecular_function
GO:0043552positive regulation of phosphatidylinositol 3-kinaIEAbiological_process
GO:0005154epidermal growth factor receptor bindingIEAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0046872metal ion bindingIEAmolecular_function
GO:0001525angiogenesisIEAbiological_process
GO:0030031cell projection assemblyIEAbiological_process
GO:0030168platelet activationTASbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0005085guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0006915apoptotic processTASbiological_process
GO:0005622intracellularIEAcellular_component


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