| UniProt/SwissProt ID: | USO1_HUMAN |
| Description: | USO1 vesicle transport factor [Source:HGNC Symbol;Acc:30904] |
| Location: | chr4 q21.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T465 | RVQLAtSIGNP | Uso1_p115_head | PhosphoSitePlus |
| S483 | CTNILsQGSKI | Uso1_p115_head | PhosphoSitePlus |
| S952 | DEDDEsEDPGK | phosphoELM | |
| S32 | CDRVAsSTLLD | PhosphoSitePlus | |
| S952 | DEDDEsEDPGK | Uso1_p115_C | PhosphoSitePlus |
| S942 | EDELEsGDQED | Uso1_p115_C | PhosphoSitePlus |
| S50 | ALKSLsKKYRL | PhosphoSitePlus | |
| S486 | ILSQGsKIQTR | Uso1_p115_head | PhosphoSitePlus |
| Y718 | QHQGSySEGAQ | PhosphoSitePlus | |
| Y655 | NIVTHyKNMIR | ADIP | PhosphoSitePlus |
| S942 | EDELEsGDQED | phosphoELM | |
| Dephosphorylation site |
| USO1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000264904 | V85L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000264904 | A250V | COSMIC | Central Nervous System Neoplasms | ENSP00000264904 | M488fs*5 | COSMIC | Ovarian Cancer | 21720365 | ENSP00000264904 | P189S | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000264904 | I257T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000264904 | Y487* | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000264904 | Breast Cancer | Normal vs. Cancer | tissue | Up | 0.67 | 20739354 | ENSP00000264904 | Breast Cancer | Normal vs. Cancer | tissue | Up | 0.67 | 20739354 | ENSP00000264904 | Testicular Cancer | Normal vs. Cancer | cell line | Up | 18489135 |
| Hyperphosphorylation site |
| USO1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CSK2B_HUMAN | USO1_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| USO1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008565 | protein transporter activity | IEA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0005829 | cytosol | IEA | cellular_component |
| GO:0000139 | Golgi membrane | IEA | cellular_component |
| GO:0005488 | binding | IEA | molecular_function |
| GO:0006886 | intracellular protein transport | IEA | biological_process |
| GO:0016192 | vesicle-mediated transport | IEA | biological_process |
| GO:0048280 | vesicle fusion with Golgi apparatus | IEA | biological_process |