| UniProt/SwissProt ID: | UNC5C_HUMAN |
| Description: | unc-5 homolog C (C. elegans) [Source:HGNC Symbol;Acc:12569] |
| Location: | chr4 q22.3 |
| Node attribute: | receptor |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T674 | LVGHStTKAAA | PhosphoSitePlus | |
| S127 | VSIEIsRQQVE | PhosphoSitePlus | |
| Y454 | YRGPVyALHDV | PhosphoSitePlus | |
| T506 | LSPQMtQSLLE | PhosphoSitePlus | |
| S123 | IVREVsIEISR | PhosphoSitePlus | |
| T832 | LDPANtITTVT | PhosphoSitePlus | |
| S843 | GPSAFsIPLPI | PhosphoSitePlus | |
| S516 | ENEALsLKNQS | PhosphoSitePlus | |
| S521 | SLKNQsLARQT | PhosphoSitePlus | |
| S460 | ALHDVsDKIPM | PhosphoSitePlus | |
| Dephosphorylation site |
| UNC5C_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000406022 | R681H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000406022 | A613T | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000406022 | Y881* | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| UNC5C_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| UNC5C_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NET1_HUMAN | UNC5C_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04360 | Axon guidance |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0043065 | positive regulation of apoptotic process | IEA | biological_process |
| GO:0007411 | axon guidance | TAS | biological_process |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0030334 | regulation of cell migration | IEA | biological_process |
| GO:0007420 | brain development | IEA | biological_process |
| GO:0005042 | netrin receptor activity | IEA | molecular_function |
| GO:0038007 | netrin-activated signaling pathway | IEA | biological_process |
| GO:0006915 | apoptotic process | IEA | biological_process |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |