| UniProt/SwissProt ID: | UNC5A_HUMAN |
| Description: | unc-5 homolog A (C. elegans) [Source:HGNC Symbol;Acc:12567] |
| Location: | chr5 q35.2 |
| Node attribute: | receptor |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y431 | LSTQNyFRSLP | PhosphoSitePlus | |
| S719 | EGDGQsFSINF | PhosphoSitePlus | |
| S232 | VARRRsASAAV | I-set | PhosphoSitePlus |
| S721 | DGQSFsINFNI | PhosphoSitePlus | |
| S586 | VGEALsVAAAK | PhosphoSitePlus | |
| Dephosphorylation site |
| UNC5A_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000332737 | E187K | COSMIC | Melanoma | 21499247 | ENSP00000332737 | V713M | COSMIC | Skin Cancer | 21984974 | ENSP00000332737 | E486K | COSMIC | Skin Cancer | 21984974 | ENSP00000332737 | R407H | COSMIC | Ovarian Cancer | 21720365 | ENSP00000332737 | E552K | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000332737 | N814K | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| UNC5A_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| UNC5A_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NET4_HUMAN | UNC5A_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04360 | Axon guidance |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0042981 | regulation of apoptotic process | TAS | biological_process |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0006915 | apoptotic process | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0007411 | axon guidance | TAS | biological_process |