| UniProt/SwissProt ID: | UBIP1_HUMAN |
| Description: | upstream binding protein 1 (LBP-1a) [Source:HGNC Symbol;Acc:12507] |
| Location: | chr3 p22.3 |
| Node attribute: | TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S425 | SLKSRsVRPRL | PhosphoSitePlus; HPRD | |
| T401 | DLLKLtKEDLV | HPRD | |
| T194 | ISTEFtPRKHG | CP2 | PhosphoSitePlus |
| Y266 | KYQPSyDTTIL | PhosphoSitePlus | |
| Y262 | HEKEKyQPSYD | PhosphoSitePlus | |
| S423 | YNSLKsRSVRP | PhosphoSitePlus; HPRD | |
| Dephosphorylation site |
| UBIP1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000283629 | E362K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000283628 | P297S | COSMIC | Ovarian Cancer | 21720365 | ENSP00000283629 | S36I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000283628 | S36I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000283629 | Q407* | COSMIC | Renal Cancer | 20054297 | ENSP00000283628 | Q407* | COSMIC | Renal Cancer | 20054297 | ENSP00000283628 | E362K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000395558 | E326K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000283629 | P297S | COSMIC | Ovarian Cancer | 21720365 | ENSP00000283628 | C339F | COSMIC | Renal Cancer | 20054297 | ENSP00000283629 | C339F | COSMIC | Renal Cancer | 20054297 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000283628 | hepatitis B virus | Normal vs. Cancer | tissue | Up | 6.3 | 14726492 |
| Hyperphosphorylation site |
| UBIP1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| UBIP1_HUMAN | CP11A_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| UBIP1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0019079 | viral genome replication | TAS | biological_process |
| GO:0005634 | nucleus | TAS | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0001525 | angiogenesis | IEA | biological_process |
| GO:0045892 | negative regulation of transcription, DNA-dependen | TAS | biological_process |
| GO:0006357 | regulation of transcription from RNA polymerase II | TAS | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | TAS | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0003714 | transcription corepressor activity | TAS | molecular_function |