| UniProt/SwissProt ID: | U2AF1_HUMAN |
| Description: | U2 small nuclear RNA auxiliary factor 1 [Source:HGNC Symbol;Acc:12453] |
| Location: | chr21 q22.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S7 | AEYLAsIFGTE | PhosphoSitePlus | |
| S231 | RDRRRsRDRER | PhosphoSitePlus | |
| S122 | RKKHRsRSRSR | HPRD | |
| S70 | LRCAVsDVEMQ | PhosphoSitePlus; HPRD | |
| S204 | SRERRsRSRDR | PhosphoSitePlus | |
| T11 | ASIFGtEKDKV | PhosphoSitePlus | |
| Y93 | EMEEKyGEVEE | RRM_1 | PhosphoSitePlus |
| S124 | KHRSRsRSRER | HPRD | |
| S197 | KHRSRsRSRER | HPRD | |
| S206 | ERRSRsRDRGR | PhosphoSitePlus | |
| S195 | RKKHRsRSRSR | HPRD | |
| S61 | QNSSQsADGLR | PhosphoSitePlus; HPRD | |
| T87 | FEEVFtEMEEK | PhosphoSitePlus; HPRD | |
| S19 | DKVNCsFYFKI | HPRD | |
| S59 | NPQNSsQSADG | PhosphoSitePlus; HPRD; phosphoELM | |
| S237 | RDRERsGRF__ | PhosphoSitePlus | |
| Y4 | __MAEyLASIF | PhosphoSitePlus | |
| S19 | DKVNCsFYFKI | zf-CCCH | PhosphoSitePlus |
| Dephosphorylation site |
| U2AF1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| U2AF1_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000291552 | Gastric Cancer | Metastasis | cell line | Up | 1.6 | 17022644 | ENSP00000291552 | Gastric Cancer | Metastasis | cell line | Up | 1.6 | 17022644 |
| Hyperphosphorylation site |
| U2AF1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CLK2_HUMAN | U2AF1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| U2AF1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006397 | mRNA processing | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0071013 | catalytic step 2 spliceosome | IDA | cellular_component |
| GO:0006369 | termination of RNA polymerase II transcription | TAS | biological_process |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0006406 | mRNA export from nucleus | TAS | biological_process |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0031124 | mRNA 3'-end processing | TAS | biological_process |
| GO:0006366 | transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0000166 | nucleotide binding | IEA | molecular_function |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0050733 | RS domain binding | IEA | molecular_function |
| GO:0005681 | spliceosomal complex | IDA | cellular_component |
| GO:0016607 | nuclear speck | IEA | cellular_component |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0015030 | Cajal body | TAS | cellular_component |
| GO:0016607 | nuclear speck | ISS | cellular_component |
| GO:0000398 | mRNA splicing, via spliceosome | IC | biological_process |
| GO:0008380 | RNA splicing | TAS | biological_process |