Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TYSY_HUMAN
Description:thymidylate synthetase [Source:HGNC Symbol;Acc:12441]
Location:chr18 p11.32
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S114WDANGsRDFLDThymidylat_syntPhosphoSitePlus
Y146HFGAEyRDMESThymidylat_syntPhosphoSitePlus
S154MESDYsGQGVDThymidylat_syntPhosphoSitePlus
S151YRDMEsDYSGQThymidylat_syntPhosphoSitePlus
T167QRVIDtIKTNPThymidylat_syntPhosphoSitePlus
Y153DMESDySGQGVHPRD
S6MPVAGsELPRRPhosphoSitePlus
T53DDRTGtGTLSVThymidylat_syntPhosphoSitePlus
S124DSLGFsTREEGThymidylat_syntPhosphoSitePlus
Y135DLGPVyGFQWRThymidylat_syntPhosphoSitePlus
S6LPRRHPRD
Y153DMESDySGQGVThymidylat_syntPhosphoSitePlus

Dephosphorylation site
TYSY_HUMAN do not have dephosphorylation site.

Mutation site
TYSY_HUMAN do not have mutation site.

Differential expressed protein
TYSY_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TYSY_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SP1_HUMANTYSY_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
TYSY_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005634nucleusIDAcellular_component
GO:0009157deoxyribonucleoside monophosphate biosynthetic proTASbiological_process
GO:0006260DNA replicationNASbiological_process
GO:0019088immortalization of host cell by virusIEAbiological_process
GO:0000083regulation of transcription involved in G1/S phaseTASbiological_process
GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0006139nucleobase-containing compound metabolic processTASbiological_process
GO:0006206pyrimidine nucleobase metabolic processTASbiological_process
GO:0007568agingIEAbiological_process
GO:0046078dUMP metabolic processIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0006206pyrimidine nucleobase metabolic processIEAbiological_process
GO:0048015phosphatidylinositol-mediated signalingNASbiological_process
GO:0005739mitochondrionIDAcellular_component
GO:0032570response to progesterone stimulusIEAbiological_process
GO:0007623circadian rhythmIEAbiological_process
GO:0048037cofactor bindingIEAmolecular_function
GO:0005730nucleolusIEAcellular_component
GO:0046683response to organophosphorusIEPbiological_process
GO:0048589developmental growthIEAbiological_process
GO:0042803protein homodimerization activityIEAmolecular_function
GO:0014070response to organic cyclic compoundIEAbiological_process
GO:0005976polysaccharide metabolic processIEAbiological_process
GO:0031100organ regenerationIEAbiological_process
GO:0051384response to glucocorticoid stimulusIEAbiological_process
GO:0005759mitochondrial matrixIDAcellular_component
GO:0000166nucleotide bindingIEAmolecular_function
GO:0046653tetrahydrofolate metabolic processIEAbiological_process
GO:0005743mitochondrial inner membraneIDAcellular_component
GO:0042493response to drugIEAbiological_process
GO:0034097response to cytokine stimulusIEAbiological_process
GO:0006231dTMP biosynthetic processIEAbiological_process
GO:0051593response to folic acidIEAbiological_process
GO:0008144drug bindingIEAmolecular_function
GO:0019860uracil metabolic processIEAbiological_process
GO:0046134pyrimidine nucleoside biosynthetic processTASbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:0005654nucleoplasmTAScellular_component
GO:0005829cytosolTAScellular_component
GO:0044281small molecule metabolic processTASbiological_process
GO:0003729mRNA bindingIEAmolecular_function
GO:0055086nucleobase-containing small molecule metabolic proTASbiological_process
GO:0005542folic acid bindingIEAmolecular_function
GO:0051216cartilage developmentIEAbiological_process
GO:0004799thymidylate synthase activityIEAmolecular_function
GO:0033189response to vitamin AIEAbiological_process
GO:0045471response to ethanolIEAbiological_process
GO:0006281DNA repairNASbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0004799thymidylate synthase activityTASmolecular_function
GO:0006235dTTP biosynthetic processIEAbiological_process
GO:0060574intestinal epithelial cell maturationIEAbiological_process
GO:0009636response to toxinIEAbiological_process


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