| UniProt/SwissProt ID: | TTHY_HUMAN |
| Description: | transthyretin [Source:HGNC Symbol;Acc:12405] |
| Location: | chr18 q12.1 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S137 | SPYSYsTTAVV | Transthyretin | PhosphoSitePlus |
| T138 | PYSYStTAVVT | Transthyretin | PhosphoSitePlus |
| T25 | AGPTGtGESKC | PhosphoSitePlus | |
| T23 | SEAGPtGTGES | PhosphoSitePlus | |
| Y125 | SGPRRyTIAAL | Transthyretin | PhosphoSitePlus |
| Dephosphorylation site |
| TTHY_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000237014 | T79I | TCGA, COSMIC | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000237014 | Pancreatic Cancer | Normal vs. Cancer | tissue | Down | 7.9 | 16212428 | ENSP00000237014 | Thyroid Carcinoma | Normal vs. Cancer | tissue | Up | 3.2 | 17194741 | ENSP00000237014 | papillary thyroid carcinoma | Normal vs. Cancer | tissue | Up | 1.5 | 18665625 | ENSP00000237014 | papillary thyroid carcinoma | Normal vs. Cancer | tissue | Up | 3.9 | 18665625 | ENSP00000237014 | papillary thyroid carcinoma | Normal vs. Cancer | tissue | Up | 1.4 | 18665625 | ENSP00000237014 | papillary thyroid carcinoma | Normal vs. Cancer | tissue | Up | 2.1 | 18665625 | ENSP00000237014 | Esophageal Cancer | Normal vs. Cancer | tissue | Down | 0.3 | 19142970 | ENSP00000237014 | Breast Cancer | Metastasis | tissue | Down | 17274072 | ENSP00000237014 | Breast Cancer | Normal vs. Cancer | tissue | Up | 18257521 | ENSP00000237014 | hepatitis B virus | Normal vs. Cancer | tissue | Down | 16240287 | ENSP00000237014 | Hepatocellular Carcinoma | Normal vs. Cancer | tissue | Down | 16240287 | ENSP00000237014 | hepatitis C virus | Normal vs. Cancer | tissue | Up | 16762624 | ENSP00000237014 | Hepatocellular Carcinoma | Normal vs. Cancer | tissue | Down | 17447055 | ENSP00000237014 | Hepatocellular Carcinoma | Normal vs. Cancer | tissue | Up | 17828420 | ENSP00000237014 | Hepatocellular Carcinoma | Normal vs. Cancer | tissue | Up | 17828420 | ENSP00000237014 | breast ductal carcinoma | Normal vs. Cancer | tissue | Down | 0.027 | 20534901 | ENSP00000237014 | breast ductal carcinoma | Normal vs. Cancer | tissue | Up | 710 | 20534901 | ENSP00000237014 | Brain Cancer | Normal vs. Cancer | tissue | Up | 5.1 | 18056677 | ENSP00000237014 | Breast Cancer | Metastasis | tissue | Down | 17274072 | ENSP00000237014 | Pancreatic Cancer | Normal vs. Cancer | tissue | Up | 2.2 | 20949480 | ENSP00000237014 | Pancreatic Cancer | Normal vs. Cancer | tissue | Up | 3.3 | 20949480 |
| Hyperphosphorylation site |
| TTHY_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| FOXP3_HUMAN | TTHY_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| TTHY_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005179 | hormone activity | IEA | molecular_function |
| GO:0006810 | transport | IEA | biological_process |
| GO:0043234 | protein complex | IEA | cellular_component |
| GO:0005615 | extracellular space | IEA | cellular_component |
| GO:0005576 | extracellular region | NAS | cellular_component |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0046982 | protein heterodimerization activity | IEA | molecular_function |
| GO:0042562 | hormone binding | IEA | molecular_function |
| GO:0042572 | retinol metabolic process | IEA | biological_process |