| UniProt/SwissProt ID: | TTF2_HUMAN |
| Description: | transcription termination factor, RNA polymerase II [Source:HGNC Symbol;Acc:12398] |
| Location: | chr1 p13.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T349 | GREAAtSSDDE | PhosphoSitePlus | |
| S399 | KVSPAsGVSKK | PhosphoSitePlus | |
| S520 | TAGGSsQCYRG | PhosphoSitePlus | |
| T465 | SPEQGtNEKSN | HPRD | |
| S251 | DVQREsEPLRE | PhosphoSitePlus; HPRD | |
| Y30 | KGKSFyVCRAD | zf-GRF | PhosphoSitePlus |
| S908 | SEAADsPRSST | SNF2_N | PhosphoSitePlus |
| S810 | GGERLsILTKS | SNF2_N | PhosphoSitePlus |
| S350 | REAATsSDDEE | PhosphoSitePlus | |
| S217 | HKRDFsEIKSQ | PhosphoSitePlus | |
| S351 | EAATSsDDEEE | PhosphoSitePlus | |
| S396 | VQRKVsPASGV | PhosphoSitePlus; HPRD | |
| S368 | SSKPGsPLLFD | PhosphoSitePlus; HPRD | |
| T813 | RLSILtKSLLL | SNF2_N | PhosphoSitePlus |
| Y416 | VARRVyLTTQL | PhosphoSitePlus | |
| Y1036 | KHGLTyATIDG | Helicase_C | PhosphoSitePlus |
| S460 | SGLTLsPEQGT | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T500 | LPRRGtQPVGS | PhosphoSitePlus; HPRD | |
| T286 | LNKEYtNWEAK | PhosphoSitePlus | |
| S810 | GGERLsILTKS | HPRD | |
| Y285 | PLNKEyTNWEA | PhosphoSitePlus | |
| S883 | NQSGRsPNNPF | SNF2_N | PhosphoSitePlus; SysPTM |
| S402 | PASGVsKKVEP | PhosphoSitePlus; HPRD | |
| S374 | PLLFDsTLDLE | HPRD | |
| Y523 | GSSQCyRGHTN | PhosphoSitePlus | |
| S221 | FSEIKsQQCQG | PhosphoSitePlus | |
| T1019 | IVSQWtNMLKV | PhosphoSitePlus | |
| T380 | TLDLEtKENLQ | PhosphoSitePlus; HPRD | |
| S883 | NQSGRsPNNPF | HPRD; phosphoELM; SysPTM | |
| S908 | SEAADsPRSST | HPRD | |
| Dephosphorylation site |
| TTF2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000358478 | E623Q | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000358478 | L958F | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000358478 | D373Y | COSMIC | Hepatocellular Carcinoma | 21822264 | ENSP00000358478 | P299S | COSMIC | Skin Cancer | 21984974 | ENSP00000358478 | L958F | COSMIC | Ovarian Cancer | 21720365 | ENSP00000358478 | L436F | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| TTF2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TTF2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCA_HUMAN | TTF2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TGFR2_HUMAN | TTF2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| TTF2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0008023 | transcription elongation factor complex | TAS | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0006397 | mRNA processing | IEA | biological_process |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0006353 | DNA-dependent transcription, termination | TAS | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005681 | spliceosomal complex | IEA | cellular_component |
| GO:0008094 | DNA-dependent ATPase activity | TAS | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0004386 | helicase activity | IEA | molecular_function |
| GO:0016787 | hydrolase activity | IEA | molecular_function |
| GO:0008026 | ATP-dependent helicase activity | IEA | molecular_function |
| GO:0008380 | RNA splicing | IEA | biological_process |
| GO:0006369 | termination of RNA polymerase II transcription | TAS | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |