| UniProt/SwissProt ID: | TSP2_HUMAN |
| Description: | thrombospondin 2 [Source:HGNC Symbol;Acc:11786] |
| Location: | chr6 q27 |
| Node attribute: | ligand |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T401 | TCGSGtQQRGR | TSP_1 | PhosphoSitePlus |
| Y1038 | SSSRFyVVMWK | TSP_C | PhosphoSitePlus |
| S318 | KTRNMsACWQD | PhosphoSitePlus | |
| S399 | SVTCGsGTQQR | TSP_1 | PhosphoSitePlus |
| S479 | KNCKGsGRETK | TSP_1 | PhosphoSitePlus |
| S1035 | GYQSSsRFYVV | TSP_C | PhosphoSitePlus |
| Y1031 | GFVFGyQSSSR | TSP_C | PhosphoSitePlus |
| S109 | EGPGLsQRQFE | PhosphoSitePlus | |
| Y1024 | DRDDDyAGFVF | TSP_C | PhosphoSitePlus |
| T332 | FAENEtWVVDS | VWC | PhosphoSitePlus |
| Dephosphorylation site |
| TSP2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000355751 | R189P | COSMIC | Ovarian Cancer | 21720365 | ENSP00000355751 | E729Q | COSMIC | Ovarian Cancer | 20826764 | ENSP00000355751 | P490L | COSMIC | Skin Cancer | 21984974 | ENSP00000355751 | P598S | COSMIC | Skin Cancer | 21984974 | ENSP00000355751 | T99M | COSMIC | Ovarian Cancer | 21720365 | ENSP00000355751 | D718N | COSMIC | Hepatocellular Carcinoma | 21822264 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000355751 | Lung Cancer | Normal vs. Cancer | tissue | Down | 0.47 | 17705522 |
| Hyperphosphorylation site |
| TSP2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TSP2_HUMAN | CD47_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05144 | Malaria |
| hsa04145 | Phagosome |
| hsa04350 | TGF-beta signaling pathway |
| hsa04512 | ECM-receptor interaction |
| hsa04510 | Focal adhesion |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016525 | negative regulation of angiogenesis | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0008201 | heparin binding | IEA | molecular_function |
| GO:0005576 | extracellular region | TAS | cellular_component |
| GO:0005604 | basement membrane | IEA | cellular_component |
| GO:0031012 | extracellular matrix | IEA | cellular_component |
| GO:0007155 | cell adhesion | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005509 | calcium ion binding | IEA | molecular_function |