Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TSP2_HUMAN
Description:thrombospondin 2 [Source:HGNC Symbol;Acc:11786]
Location:chr6 q27
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T401TCGSGtQQRGRTSP_1PhosphoSitePlus
Y1038SSSRFyVVMWKTSP_CPhosphoSitePlus
S318KTRNMsACWQDPhosphoSitePlus
S399SVTCGsGTQQRTSP_1PhosphoSitePlus
S479KNCKGsGRETKTSP_1PhosphoSitePlus
S1035GYQSSsRFYVVTSP_CPhosphoSitePlus
Y1031GFVFGyQSSSRTSP_CPhosphoSitePlus
S109EGPGLsQRQFEPhosphoSitePlus
Y1024DRDDDyAGFVFTSP_CPhosphoSitePlus
T332FAENEtWVVDSVWCPhosphoSitePlus

Dephosphorylation site
TSP2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000355751R189PCOSMICOvarian Cancer21720365
ENSP00000355751E729QCOSMICOvarian Cancer20826764
ENSP00000355751P490LCOSMICSkin Cancer21984974
ENSP00000355751P598SCOSMICSkin Cancer21984974
ENSP00000355751T99MCOSMICOvarian Cancer21720365
ENSP00000355751D718NCOSMICHepatocellular Carcinoma21822264

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000355751Lung CancerNormal vs. CancertissueDown0.4717705522

Hyperphosphorylation site
TSP2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TSP2_HUMANCD47_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05144Malaria
hsa04145Phagosome
hsa04350TGF-beta signaling pathway
hsa04512ECM-receptor interaction
hsa04510Focal adhesion

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016525negative regulation of angiogenesisIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0008201heparin bindingIEAmolecular_function
GO:0005576extracellular regionTAScellular_component
GO:0005604basement membraneIEAcellular_component
GO:0031012extracellular matrixIEAcellular_component
GO:0007155cell adhesionIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005509calcium ion bindingIEAmolecular_function


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