| UniProt/SwissProt ID: | TRPV6_HUMAN |
| Description: | transient receptor potential cation channel, subfamily V, member 6 [Source:HGNC Symbol;Acc:14006] |
| Location: | chr7 q34 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T702 | RLRQGtLRRDL | PKCa | RegPhos |
| T702 | RLRQGtLRRDL | PhosphoSitePlus | |
| T688 | SVSRStSRSSA | PhosphoSitePlus | |
| S144 | RRASVsARATG | Ank_2 | PhosphoSitePlus |
| T148 | VSARAtGTAFR | PhosphoSitePlus | |
| T702 | RLRQGtLRRDL | PKCa(PKC alpha | RegPhos |
| T702 | RLRQGtLRRDL | PRKCA | HPRD |
| Y278 | LTSTLyDLTEI | PhosphoSitePlus | |
| Y67 | NKLLKyEDCKV | Ank_2 | PhosphoSitePlus |
| S142 | LARRAsVSARA | Ank_2 | PhosphoSitePlus |
| T702 | RLRQGtLRRDL | PKC_alpha | phosphoELM |
| T601 | QIVATtVMLER | HPRD; phosphoELM | |
| Dephosphorylation site |
| TRPV6_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000352358 | R414H | COSMIC | Ovarian Cancer | 20826764 | ENSP00000352358 | S683L | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000352358 | T298I | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000352358 | P672S | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| TRPV6_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TRPV6_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCA_HUMAN | TRPV6_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04978 | Mineral absorption |
| hsa04970 | Salivary secretion |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005516 | calmodulin binding | IDA | molecular_function |
| GO:0006816 | calcium ion transport | NAS | biological_process |
| GO:0006811 | ion transport | IEA | biological_process |
| GO:0005262 | calcium channel activity | IEA | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0006816 | calcium ion transport | IEA | biological_process |
| GO:0005216 | ion channel activity | IEA | molecular_function |
| GO:0017158 | regulation of calcium ion-dependent exocytosis | NAS | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0055085 | transmembrane transport | IEA | biological_process |