Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TRPC3_HUMAN
Description:transient receptor potential cation channel, subfamily C, member 3 [Source:HGNC Symbol;Acc:12335]
Location:chr4 q27
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T11SLRRMtVMREKPRKG1HPRD
T11SLRRMtVMREKPKG1RegPhos
S263DYRKLsMQCKDPRKG1HPRD
S712FSLVPsPKSFVPKC_alphaphosphoELM
S712FSLVPsPKSFVPKCaRegPhos
S263DYRKLsMQCKDPKG1RegPhos
S712FSLVPsPKSFVPRKCAHPRD
S712FSLVPsPKSFVPKCa(PKC alphaRegPhos

Dephosphorylation site
TRPC3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000368966W530RBIOMARTBreast Cancer21930507, 21930502
ENSP00000264811R308PCOSMICOvarian Cancer21720365
ENSP00000264811W457RBIOMARTBreast Cancer21930507, 21930502
ENSP00000264811A525TCOSMICHead and Neck Cancer21798893
ENSP00000264811V710ACOSMICOvarian Cancer21720365

Differential expressed protein
TRPC3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TRPC3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANTRPC3_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KGP1_HUMANTRPC3_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
TRPC3_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005886plasma membraneTAScellular_component
GO:0007602phototransductionTASbiological_process
GO:0070588calcium ion transmembrane transportIDAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0055085transmembrane transportIEAbiological_process
GO:0015279store-operated calcium channel activityTASmolecular_function
GO:0005887integral to plasma membraneIDAcellular_component
GO:0016020membraneIEAcellular_component
GO:0005488bindingIEAmolecular_function
GO:0005262calcium channel activityTASmolecular_function
GO:0030168platelet activationTASbiological_process
GO:0006811ion transportIEAbiological_process
GO:0051592response to calcium ionIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0007411axon guidanceTASbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0070679inositol 1,4,5 trisphosphate bindingIDAmolecular_function
GO:0006816calcium ion transportTASbiological_process
GO:0033198response to ATPIDAbiological_process
GO:0005216ion channel activityIEAmolecular_function
GO:0010524positive regulation of calcium ion transport into IDAbiological_process


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