| UniProt/SwissProt ID: | TRPC3_HUMAN |
| Description: | transient receptor potential cation channel, subfamily C, member 3 [Source:HGNC Symbol;Acc:12335] |
| Location: | chr4 q27 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T11 | SLRRMtVMREK | PRKG1 | HPRD |
| T11 | SLRRMtVMREK | PKG1 | RegPhos |
| S263 | DYRKLsMQCKD | PRKG1 | HPRD |
| S712 | FSLVPsPKSFV | PKC_alpha | phosphoELM |
| S712 | FSLVPsPKSFV | PKCa | RegPhos |
| S263 | DYRKLsMQCKD | PKG1 | RegPhos |
| S712 | FSLVPsPKSFV | PRKCA | HPRD |
| S712 | FSLVPsPKSFV | PKCa(PKC alpha | RegPhos |
| Dephosphorylation site |
| TRPC3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000368966 | W530R | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000264811 | R308P | COSMIC | Ovarian Cancer | 21720365 | ENSP00000264811 | W457R | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000264811 | A525T | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000264811 | V710A | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| TRPC3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TRPC3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCA_HUMAN | TRPC3_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| KGP1_HUMAN | TRPC3_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| TRPC3_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0007602 | phototransduction | TAS | biological_process |
| GO:0070588 | calcium ion transmembrane transport | IDA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0055085 | transmembrane transport | IEA | biological_process |
| GO:0015279 | store-operated calcium channel activity | TAS | molecular_function |
| GO:0005887 | integral to plasma membrane | IDA | cellular_component |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0005488 | binding | IEA | molecular_function |
| GO:0005262 | calcium channel activity | TAS | molecular_function |
| GO:0030168 | platelet activation | TAS | biological_process |
| GO:0006811 | ion transport | IEA | biological_process |
| GO:0051592 | response to calcium ion | IDA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0007411 | axon guidance | TAS | biological_process |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0070679 | inositol 1,4,5 trisphosphate binding | IDA | molecular_function |
| GO:0006816 | calcium ion transport | TAS | biological_process |
| GO:0033198 | response to ATP | IDA | biological_process |
| GO:0005216 | ion channel activity | IEA | molecular_function |
| GO:0010524 | positive regulation of calcium ion transport into | IDA | biological_process |