Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TRFE_HUMAN
Description:transferrin [Source:HGNC Symbol;Acc:11740]
Location:chr3 q22.1
Node attribute:ligand; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T349NLREGtCPEAPPhosphoSitePlus
Y536EGYYGyTGAFRHPRD; phosphoELM
Y593KPVEEyANCHLTransferrinPhosphoSitePlus
T36SEHEAtKCQSFTransferrinPhosphoSitePlus
Y207NQYFGySGAFKTransferrinPhosphoSitePlus
Y257KPVDEyKDCHLTransferrinPhosphoSitePlus
Y674YLGEEyVKAVGTransferrinPhosphoSitePlus
Y533NNKEGyYGYTGTransferrinPhosphoSitePlus
T686LRKCStSSLLEPhosphoSitePlus
Y64VKKASyLDCIRTransferrinPhosphoSitePlus
T139KKSCHtGLGRSTransferrinPhosphoSitePlus
T476TAVGRtAGWNITransferrinPhosphoSitePlus
S136LRGKKsCHTGLTransferrinPhosphoSitePlus
S63CVKKAsYLDCITransferrinPhosphoSitePlus
S468LKGKKsCHTAVTransferrinPhosphoSitePlus
Y666HDRNTyEKYLGTransferrinPhosphoSitePlus
T355CPEAPtDECKPPhosphoSitePlus
T694LLEACtFRRP_PhosphoSitePlus
Y534NKEGYyGYTGATransferrinPhosphoSitePlus
T340GYEYVtAIRNLTransferrinPhosphoSitePlus
S688KCSTSsLLEACPhosphoSitePlus
Y536EGYYGyTGAFRTransferrinPhosphoSitePlus
Y669NTYEKyLGEEYTransferrinPhosphoSitePlus
Y155PIGLLyCDLPETransferrinPhosphoSitePlus
T537GYYGYtGAFRCTransferrinPhosphoSitePlus

Dephosphorylation site
TRFE_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000385834E337QBIOMARTBreast Cancer21930507, 21930502
ENSP00000385834F173LBIOMARTBreast Cancer21930507, 21930502
ENSP00000385834W363CTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
TRFE_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y536TransferrinNKEGYYGyTGAFRCLcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
TRFE_HUMANTFR1_HUMANligand -> receptorHPMR
CEBPA_HUMANTRFE_HUMANTF -> target geneTRANSFAC
COT1_HUMANTRFE_HUMANTF -> target geneTRANSFAC
ESR1_HUMANTRFE_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04978Mineral absorption

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016023cytoplasmic membrane-bounded vesicleIDAcellular_component
GO:0048471perinuclear region of cytoplasmIDAcellular_component
GO:0033572transferrin transportTASbiological_process
GO:0005905coated pitIDAcellular_component
GO:0016324apical plasma membraneIDAcellular_component
GO:0008199ferric iron bindingIEAmolecular_function
GO:0030139endocytic vesicleIDAcellular_component
GO:0006826iron ion transportIEAbiological_process
GO:0045178basal part of cellIDAcellular_component
GO:0005576extracellular regionIEAcellular_component
GO:0002576platelet degranulationTASbiological_process
GO:0005770late endosomeIDAcellular_component
GO:0030141secretory granuleTAScellular_component
GO:0031625ubiquitin protein ligase bindingIEAmolecular_function
GO:0006879cellular iron ion homeostasisIEAbiological_process
GO:0055037recycling endosomeIDAcellular_component
GO:0010008endosome membraneTAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005769early endosomeIDAcellular_component
GO:0005739mitochondrionIDAcellular_component
GO:0009925basal plasma membraneIDAcellular_component
GO:0030168platelet activationTASbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0055085transmembrane transportTASbiological_process


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