| UniProt/SwissProt ID: | TR10A_HUMAN |
| Description: | tumor necrosis factor receptor superfamily, member 10a [Source:HGNC Symbol;Acc:11904] |
| Location: | chr8 p21.3 |
| Node attribute: | receptor; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S463 | EDGTGsAVS | HPRD; phosphoELM | |
| S466 | TGSAVsLE___ | PhosphoSitePlus | |
| S466 | TGSAVs | HPRD; phosphoELM | |
| S83 | PAREAsPRLRV | PhosphoSitePlus; phosphoELM; SysPTM | |
| Y456 | SGKFIyLEDGT | PhosphoSitePlus | |
| T461 | YLEDGtGSAVS | PhosphoSitePlus; phosphoELM | |
| S424 | TGRNAsIHTLL | HPRD | |
| S463 | EDGTGsAVSLE | PhosphoSitePlus | |
| Dephosphorylation site |
| TR10A_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000221132 | C132F | COSMIC | Ovarian Cancer | 21720365 | ENSP00000221132 | K443N | COSMIC | Central Nervous System Neoplasms | 18772890 | ENSP00000221132 | R147Q | COSMIC | Ovarian Cancer | 21720365 | ENSP00000221132 | A70T | COSMIC | Central Nervous System Neoplasms | 18772890 | ENSP00000221132 | P64S | COSMIC | Central Nervous System Neoplasms | 18772890 |
| Differential expressed protein |
| TR10A_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TR10A_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TNF10_HUMAN | TR10A_HUMAN | ligand -> receptor | HPMR |
| TNF10_HUMAN | TR10A_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04210 | Apoptosis |
| hsa05164 | Influenza A |
| hsa05162 | Measles |
| hsa04060 | Cytokine-cytokine receptor interaction |
| hsa04650 | Natural killer cell mediated cytotoxicity |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0071260 | cellular response to mechanical stimulus | IEP | biological_process |
| GO:0008134 | transcription factor binding | IPI | molecular_function |
| GO:0004872 | receptor activity | NAS | molecular_function |
| GO:0045569 | TRAIL binding | NAS | molecular_function |
| GO:0007250 | activation of NF-kappaB-inducing kinase activity | NAS | biological_process |
| GO:0097191 | extrinsic apoptotic signaling pathway | IDA | biological_process |
| GO:0016021 | integral to membrane | IC | cellular_component |
| GO:0008625 | extrinsic apoptotic signaling pathway via death do | NAS | biological_process |
| GO:0006917 | induction of apoptosis | NAS | biological_process |
| GO:0005035 | death receptor activity | TAS | molecular_function |
| GO:0006919 | activation of cysteine-type endopeptidase activity | NAS | biological_process |