Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TPM2_HUMAN
Description:tropomyosin 2 (beta) [Source:HGNC Symbol;Acc:12011]
Location:chr9 p13.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S158HIAEDsDRKYETropomyosinPhosphoSitePlus
S87EADVAsLNRRIHPRD
Y221TKEDKyEEEIKTropomyosinPhosphoSitePlus
Y267AQKMKyKAISETropomyosinPhosphoSitePlus
T108QERLAtALQKLTropomyosinPhosphoSitePlus
S63EKYSEsVKEAQTropomyosinPhosphoSitePlus
Y60DEVEKySESVKTropomyosinPhosphoSitePlus
T252AKLEKtIDDLEHPRD
S283LNDITsL____TropomyosinPhosphoSitePlus
T53KKLKGtEDEVETropomyosinPhosphoSitePlus
T252AKLEKtIDDLETropomyosinPhosphoSitePlus
T79AEKKAtDAEADTropomyosinPhosphoSitePlus
S87EADVAsLNRRITropomyosinPhosphoSitePlus
S61EVEKYsESVKEPIK3CGHPRD
Y162DSDRKyEEVARTropomyosinPhosphoSitePlus
Y261LEDEVyAQKMKTropomyosinPhosphoSitePlus
T282ALNDItSL___TropomyosinPhosphoSitePlus

Dephosphorylation site
TPM2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000354219V64LCOSMICOvarian Cancer21720365
ENSP00000367542E122DBIOMARTBreast Cancer21930507, 21930502
ENSP00000354219E122DBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000354219Breast CancerMetastasiscell lineUp16637015
ENSP00000354219Esophageal CancerNormal vs. CancertissueUp2.119142970
ENSP00000354219Esophageal CancerNormal vs. CancertissueUp2.219142970
ENSP00000354219Oral CancerNormal vs. CancertissueUp616889763
ENSP00000354219Breast CancerMetastasiscell lineUp16637015
ENSP00000354219hepatitis C virusNormal vs. CancertissueUp16762624
ENSP00000354219Lung CancerCancer vs. Cancercell lineUp17284061
ENSP00000354219Breast CancerNormal vs. CancertissueUp20560667
ENSP00000354219Breast CancerNormal vs. CancertissueDown0.620739354
ENSP00000354219Breast CancerNormal vs. CancertissueDown0.620739354
ENSP00000354219Ovarian CancerMetastasiscell lineDown17892554
ENSP00000354219Gastric CancerNormal vs. CancertissueUp4.715761955
ENSP00000354219Uterine CancerNormal vs. CancertissueDown16051329
ENSP00000354219Uterine CancerNormal vs. CancertissueDown19771267
ENSP00000354219pancreatic ductal adenocarcinomaNormal vs. CancertissueUp17492507

Hyperphosphorylation site
TPM2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PK3CG_HUMANTPM2_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05414Dilated cardiomyopathy
hsa04260Cardiac muscle contraction
hsa05410Hypertrophic cardiomyopathy (HCM)

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003779actin bindingIDAmolecular_function
GO:0043462regulation of ATPase activityIDAbiological_process
GO:0005862muscle thin filament tropomyosinTAScellular_component
GO:0008307structural constituent of muscleTASmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0030049muscle filament slidingTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0006936muscle contractionTASbiological_process


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