Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TPIS_HUMAN
Description:triosephosphate isomerase 1 [Source:HGNC Symbol;Acc:12009]
Location:chr12 p13.31
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S260CKELAsQPDVDTIMPhosphoSitePlus
S235LKSNVsDAVAQTIMPhosphoSitePlus
T28RLRADtDLQRLPhosphoSitePlus
Y105AAQNCyKVTNGTIMPhosphoSitePlus
S204DAVAQsTRIIYHPRD
Y16HFAALyISGQWPhosphoSitePlus
S58NGRKQsLGELITIMPhosphoSitePlus
T251YGGSVtGATCKTIMPhosphoSitePlus
S249IIYGGsVTGATTIMPhosphoSitePlus
S241DAVAQsTRIIYTIMPhosphoSitePlus
T108NCYKVtNGAFTTIMPhosphoSitePlus
S232RGWLKsNVSDATIMPhosphoSitePlus
T28GELIGtLNAAKHPRD
S117FTGEIsPGMIKTIMPhosphoSitePlus
S21NGRKQsLGELIHPRD; phosphoELM; SysPTM
T65GELIGtLNAAKTIMPhosphoSitePlus
Y85APPTAyIDFARTIMPhosphoSitePlus
S143HVFGEsDELIGTIMPhosphoSitePlus
S80FTGEIsPGMIKHPRD; SysPTM
T71NCYKVtNGAFTHPRD
Y246STRIIyGGSVTTIMPhosphoSitePlus
S198LKSNVsDAVAQHPRD
Y202KVVLAyEPVWATIMPhosphoSitePlus
S195RGWLKsNVSDAHPRD

Dephosphorylation site
TPIS_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000379933V213LCOSMICSkin Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000379933Non-small cell lung carcinomaMetastasiscell lineUp17537172
ENSP00000379933hepatitis C virusNormal vs. CancertissueDown0.318715028
ENSP00000379933Breast CancerTreatment (none vs. SEL1L treatment)cell lineDown0.1115880780
ENSP00000379933Hepatocellular CarcinomaNormal vs. CancertissueDown0.0615759316
ENSP00000379933Breast CancerNormal vs. CancertissueUp215767701
ENSP00000379933Breast CancerTreatment (chemosensitive vs. adriamycin-resistant)cell lineUp2.417487377
ENSP00000379933hepatitis C virusNormal vs. CancertissueDown16762624
ENSP00000379933hepatitis C virusNormal vs. CancertissueUp16762624
ENSP00000379933Hepatocellular CarcinomaTreatment (none vs. Suberonylanilide hydroxamic acid (SAHA) treatment)tissueUp17593366
ENSP00000379933hepatitis B virusNormal vs. CancertissueDown0.3817671684
ENSP00000379933Hepatocellular CarcinomaCancer vs. Cancer (HCC vs. HuCCA)cell lineUp20069059
ENSP00000379933Lung CancerNormal vs. CancertissueUp16342241
ENSP00000379933Lung CancerNormal vs. CancertissueUp16342241
ENSP00000379933Non-small cell lung carcinomaMetastasiscell lineDown0.3117418446
ENSP00000379933Lung CancerTreatment (none vs. Mitoxantrone resistance)cell lineDown0.817593620
ENSP00000379933Lung CancerTreatment (none vs transfected with pc3.1-hPNAS5)cell lineDown19795389
ENSP00000379933Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineDown0.120804217
ENSP00000379933Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineDown0.3420804217
ENSP00000379933Gastric CancerTreatment (none vs. drug-resistant)cell lineDown18309519
ENSP00000379933Breast CancerNormal vs. CancertissueUp3.620005186
ENSP00000379933Breast CancerNormal vs. CancertissueUp>1020005186
ENSP00000379933Breast CancerNormal vs. Cancercell lineUp1.520052998
ENSP00000379933Breast CancerNormal vs. Cancercell lineUp1.620052998
ENSP00000379933Breast CancerNormal vs. Cancercell lineDown0.6920052998
ENSP00000379933Breast CancerNormal vs. Cancercell lineDown0.9520052998
ENSP00000379933Breast CancerMetastasiscell lineDown0.4620052998
ENSP00000379933Breast CancerMetastasiscell lineDown0.620052998
ENSP00000379933Breast CancerNormal vs. CancertissueUp20560667
ENSP00000379933chronic myeloid leukemiaTreatment (Imatinib-sensitive vs. Imatinib-resistant)cell lineUp1.320417730
ENSP00000379933LeukemiaCancer vs. Cancer (subtype)tissueUp15501966
ENSP00000379933acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp1417655343
ENSP00000379933acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp2617655343
ENSP00000379933Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 3 hour)cell lineDown0.315169874
ENSP00000379933Renal CancerNormal vs. CancertissueUp1.7-4.412923786
ENSP00000379933Renal CancerNormal vs. CancertissueUp2.7-6.1 12923786
ENSP00000379933Ovarian CancerTreatment (Paclitaxel-sensitive vs. Paclitaxel-resistant)cell lineUp1.419714814
ENSP00000379933Ovarian CancerTreatment (Paclitaxel-sensitive vs. Paclitaxel-resistant)cell lineUp2.519951750
ENSP00000379933Biliary Tract CancerMetastasiscell lineUp3.819299076
ENSP00000379933Esophageal CancerNormal vs. Cancercell lineDown0.2819090015
ENSP00000379933Esophageal CancerNormal vs. Cancercell lineDown0.3619090015
ENSP00000379933Pancreatic CancerNormal vs. CancertissueUp319199705

Hyperphosphorylation site
TPIS_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SP1_HUMANTPIS_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
TPIS_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006098pentose-phosphate shuntIEAbiological_process
GO:0005975carbohydrate metabolic processTASbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0009790embryo developmentIEAbiological_process
GO:0006096glycolysisIEAbiological_process
GO:0016853isomerase activityIEAmolecular_function
GO:0006094gluconeogenesisIEAbiological_process
GO:0006006glucose metabolic processTASbiological_process
GO:0019682glyceraldehyde-3-phosphate metabolic processIEAbiological_process
GO:0004807triose-phosphate isomerase activityTASmolecular_function
GO:0008152metabolic processIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0006006glucose metabolic processIEAbiological_process
GO:0007275multicellular organismal developmentIEAbiological_process
GO:0004807triose-phosphate isomerase activityIEAmolecular_function


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