Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TOPRS_HUMAN
Description:topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:21653]
Location:chr9 p21.1
Node attribute:TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S570STSLSsPRNLNPhosphoSitePlus
Y584RGDRVySPYNHPhosphoSitePlus
S196SVYSPsGPVNRPhosphoSitePlus
T909SPVVItIDSDSHPRD
T205NRRTTtPPDSGPhosphoSitePlus; HPRD; phosphoELM
S736SRQSSsPEFRVPhosphoSitePlus
S12LGSPLsREEGEPhosphoSitePlus; HPRD
Y180DRRFRyRTTLTPhosphoSitePlus
S902HGDNAsRSPVVHPRD; phosphoELM
S569RSTSLsSPRNLPhosphoSitePlus; HPRD
S577RNLNSsVRGDRHPRD
T784TASTGtDRVRNPhosphoSitePlus
S718RDGYEsSYRRRPhosphoSitePlus
S734HYSRQsSSPEFPhosphoSitePlus
T173NGSFVtPDRRFPhosphoSitePlus
T491PLAERtPELVEPhosphoSitePlus
S501ELSSDsEDLGSPhosphoSitePlus
S731SRAHYsRQSSSPhosphoSitePlus
Y263FRRTLyRAGARPhosphoSitePlus
S194NASVYsPSGPVPhosphoSitePlus; HPRD; phosphoELM
S918DSDKDsEVKEDHPRD; phosphoELM
S1028SRQLPsPRTSLPhosphoSitePlus
Y193RNASVySPSGPPhosphoSitePlus
S904DNASRsPVVITHPRD
T183FRYRTtLTRERPhosphoSitePlus
S864KRKTRsLSVEIPhosphoSitePlus
S45CRHRPsFLGCRPhosphoSitePlus
S781RSRTAsTGTDRPhosphoSitePlus
S585GDRVYsPYNHRPhosphoSitePlus; HPRD
S914TIDSDsDKDSEPhosphoSitePlus; HPRD; phosphoELM
S498ELVELsSDSEDPhosphoSitePlus
S735YSRQSsSPEFRPhosphoSitePlus
S98VPADAsPDSKCPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S866KTRSLsVEIVYPhosphoSitePlus
S567EKRSTsLSSPRPhosphoSitePlus
S499LVELSsDSEDLPhosphoSitePlus
S912VITIDsDSDKDPhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site
TOPRS_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000353735V128ICOSMICOvarian Cancer21720365
ENSP00000353735C292YCOSMICHead and Neck Cancer21798897
ENSP00000353735T185KCOSMICOvarian Cancer21720365
ENSP00000353735E808*COSMICOvarian Cancer21720365
ENSP00000353735R347*COSMICSkin Cancer21984974

Differential expressed protein
TOPRS_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TOPRS_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TOPRS_HUMANTLN1_HUMANTF -> target geneTRANSFAC
TOPRS_HUMANCADH1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
TOPRS_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0032391photoreceptor connecting ciliumIEAcellular_component
GO:0003823antigen bindingIPImolecular_function
GO:0005814centrioleIDAcellular_component
GO:0046548retinal rod cell developmentISSbiological_process
GO:0035845photoreceptor cell outer segment organizationISSbiological_process
GO:0006974response to DNA damage stimulusIDAbiological_process
GO:0046549retinal cone cell developmentISSbiological_process
GO:0010842retina layer formationISSbiological_process
GO:0044547DNA topoisomerase bindingIPImolecular_function
GO:0006915apoptotic processIEAbiological_process
GO:0000930gamma-tubulin complexIDAcellular_component
GO:0070936protein K48-linked ubiquitinationIDAbiological_process
GO:0032391photoreceptor connecting ciliumIDAcellular_component
GO:0019789SUMO ligase activityIDAmolecular_function
GO:0006351transcription, DNA-dependentNASbiological_process
GO:0008630intrinsic apoptotic signaling pathway in response IDAbiological_process
GO:0006513protein monoubiquitinationIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0004842ubiquitin-protein ligase activityIDAmolecular_function
GO:0030496midbodyTAScellular_component
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0034504protein localization to nucleusIMPbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0006511ubiquitin-dependent protein catabolic processIMPbiological_process
GO:0000922spindle poleIDAcellular_component
GO:0036064cilium basal bodyIEAcellular_component
GO:0051457maintenance of protein location in nucleusIDAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0016607nuclear speckIDAcellular_component
GO:0008270zinc ion bindingIEAmolecular_function
GO:0016925protein sumoylationIDAbiological_process
GO:0005868cytoplasmic dynein complexTAScellular_component
GO:0036064cilium basal bodyIDAcellular_component
GO:0043066negative regulation of apoptotic processISSbiological_process
GO:0043161proteasomal ubiquitin-dependent protein catabolic IMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0016605PML bodyIDAcellular_component
GO:0051443positive regulation of ubiquitin-protein ligase acIDAbiological_process


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