| UniProt/SwissProt ID: | TOPRS_HUMAN |
| Description: | topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:21653] |
| Location: | chr9 p21.1 |
| Node attribute: | TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S570 | STSLSsPRNLN | PhosphoSitePlus | |
| Y584 | RGDRVySPYNH | PhosphoSitePlus | |
| S196 | SVYSPsGPVNR | PhosphoSitePlus | |
| T909 | SPVVItIDSDS | HPRD | |
| T205 | NRRTTtPPDSG | PhosphoSitePlus; HPRD; phosphoELM | |
| S736 | SRQSSsPEFRV | PhosphoSitePlus | |
| S12 | LGSPLsREEGE | PhosphoSitePlus; HPRD | |
| Y180 | DRRFRyRTTLT | PhosphoSitePlus | |
| S902 | HGDNAsRSPVV | HPRD; phosphoELM | |
| S569 | RSTSLsSPRNL | PhosphoSitePlus; HPRD | |
| S577 | RNLNSsVRGDR | HPRD | |
| T784 | TASTGtDRVRN | PhosphoSitePlus | |
| S718 | RDGYEsSYRRR | PhosphoSitePlus | |
| S734 | HYSRQsSSPEF | PhosphoSitePlus | |
| T173 | NGSFVtPDRRF | PhosphoSitePlus | |
| T491 | PLAERtPELVE | PhosphoSitePlus | |
| S501 | ELSSDsEDLGS | PhosphoSitePlus | |
| S731 | SRAHYsRQSSS | PhosphoSitePlus | |
| Y263 | FRRTLyRAGAR | PhosphoSitePlus | |
| S194 | NASVYsPSGPV | PhosphoSitePlus; HPRD; phosphoELM | |
| S918 | DSDKDsEVKED | HPRD; phosphoELM | |
| S1028 | SRQLPsPRTSL | PhosphoSitePlus | |
| Y193 | RNASVySPSGP | PhosphoSitePlus | |
| S904 | DNASRsPVVIT | HPRD | |
| T183 | FRYRTtLTRER | PhosphoSitePlus | |
| S864 | KRKTRsLSVEI | PhosphoSitePlus | |
| S45 | CRHRPsFLGCR | PhosphoSitePlus | |
| S781 | RSRTAsTGTDR | PhosphoSitePlus | |
| S585 | GDRVYsPYNHR | PhosphoSitePlus; HPRD | |
| S914 | TIDSDsDKDSE | PhosphoSitePlus; HPRD; phosphoELM | |
| S498 | ELVELsSDSED | PhosphoSitePlus | |
| S735 | YSRQSsSPEFR | PhosphoSitePlus | |
| S98 | VPADAsPDSKC | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S866 | KTRSLsVEIVY | PhosphoSitePlus | |
| S567 | EKRSTsLSSPR | PhosphoSitePlus | |
| S499 | LVELSsDSEDL | PhosphoSitePlus | |
| S912 | VITIDsDSDKD | PhosphoSitePlus; HPRD; phosphoELM | |
| Dephosphorylation site |
| TOPRS_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000353735 | V128I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000353735 | C292Y | COSMIC | Head and Neck Cancer | 21798897 | ENSP00000353735 | T185K | COSMIC | Ovarian Cancer | 21720365 | ENSP00000353735 | E808* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000353735 | R347* | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| TOPRS_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TOPRS_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TOPRS_HUMAN | TLN1_HUMAN | TF -> target gene | TRANSFAC |
| TOPRS_HUMAN | CADH1_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| TOPRS_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0032391 | photoreceptor connecting cilium | IEA | cellular_component |
| GO:0003823 | antigen binding | IPI | molecular_function |
| GO:0005814 | centriole | IDA | cellular_component |
| GO:0046548 | retinal rod cell development | ISS | biological_process |
| GO:0035845 | photoreceptor cell outer segment organization | ISS | biological_process |
| GO:0006974 | response to DNA damage stimulus | IDA | biological_process |
| GO:0046549 | retinal cone cell development | ISS | biological_process |
| GO:0010842 | retina layer formation | ISS | biological_process |
| GO:0044547 | DNA topoisomerase binding | IPI | molecular_function |
| GO:0006915 | apoptotic process | IEA | biological_process |
| GO:0000930 | gamma-tubulin complex | IDA | cellular_component |
| GO:0070936 | protein K48-linked ubiquitination | IDA | biological_process |
| GO:0032391 | photoreceptor connecting cilium | IDA | cellular_component |
| GO:0019789 | SUMO ligase activity | IDA | molecular_function |
| GO:0006351 | transcription, DNA-dependent | NAS | biological_process |
| GO:0008630 | intrinsic apoptotic signaling pathway in response | IDA | biological_process |
| GO:0006513 | protein monoubiquitination | IDA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0004842 | ubiquitin-protein ligase activity | IDA | molecular_function |
| GO:0030496 | midbody | TAS | cellular_component |
| GO:0042127 | regulation of cell proliferation | IEA | biological_process |
| GO:0045893 | positive regulation of transcription, DNA-dependen | IEA | biological_process |
| GO:0034504 | protein localization to nucleus | IMP | biological_process |
| GO:0003677 | DNA binding | IDA | molecular_function |
| GO:0006511 | ubiquitin-dependent protein catabolic process | IMP | biological_process |
| GO:0000922 | spindle pole | IDA | cellular_component |
| GO:0036064 | cilium basal body | IEA | cellular_component |
| GO:0051457 | maintenance of protein location in nucleus | IDA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0016607 | nuclear speck | IDA | cellular_component |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0016925 | protein sumoylation | IDA | biological_process |
| GO:0005868 | cytoplasmic dynein complex | TAS | cellular_component |
| GO:0036064 | cilium basal body | IDA | cellular_component |
| GO:0043066 | negative regulation of apoptotic process | ISS | biological_process |
| GO:0043161 | proteasomal ubiquitin-dependent protein catabolic | IMP | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0016605 | PML body | IDA | cellular_component |
| GO:0051443 | positive regulation of ubiquitin-protein ligase ac | IDA | biological_process |