Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TOPB1_HUMAN
Description:topoisomerase (DNA) II binding protein 1 [Source:HGNC Symbol;Acc:17008]
Location:chr3 q22.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1002MSLDIsAVQDGPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S554EEGLFsQKSFLBRCTPhosphoSitePlus
T742LIENStKEERSPhosphoSitePlus
T1221SEELEtPIKDSPhosphoSitePlus; HPRD
S498QYENGsSTVVEPhosphoSitePlus
T848LAALEtPGRPSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S853TPGRPsQQKRKATMHPRD; RegPhos
S805RQVAAsPAVGQPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S1138VNTEPsQNEQIPhosphoSitePlus; phosphoELM; RegPhos
S1138VNTEPsQNEQIATMHPRD; RegPhos
S350ENLDVsAFQAPPhosphoSitePlus; HPRD
S860QKRKPsTPLSEPhosphoSitePlus; HPRD; phosphoELM
S492DEDLLsQYENGPhosphoSitePlus; phosphoELM; RegPhos
Y127EEVHKyVQMMGBRCTPhosphoSitePlus
T1062SKGVLtQTLEMATMHPRD; RegPhos
T1062SKGVLtQTLEMPhosphoSitePlus; phosphoELM; RegPhos
S554EEGLFsQKSFLATMHPRD; RegPhos
T144LNVSVtHLIAGHPRD
S888VALSAsPQLKEPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S301SSTPTsQINTIPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S587IMSLLsRTVADBRCTPhosphoSitePlus
T779RKTVVtPLDMNPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S1093QGQRTsLSRSGPhosphoSitePlus
S1504LGTGLsQKRKAPhosphoSitePlus
S1012GRLCNsRLLSAPhosphoSitePlus; HPRD; SysPTM
S886NAVALsASPQLPhosphoSitePlus; HPRD
S153AGEVGsKKYLVBRCTPhosphoSitePlus
S492DEDLLsQYENGATMHPRD; RegPhos
S1159RARLAsNLQWPPhosphoSitePlus
S142RDLNVsVTHLIBRCTPhosphoSitePlus
S499YENGSsTVVEAPhosphoSitePlus
T298MPNSStPTSQIPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S142RDLNVsVTHLIHPRD
T861KRKPStPLSEVPhosphoSitePlus; HPRD; phosphoELM
S864PSTPLsEVIVKPhosphoSitePlus; HPRD; phosphoELM
T300NSSTPtSQINTPhosphoSitePlus
T618NTWLVtCIDYQBRCTPhosphoSitePlus
S741FLIENsTKEERPhosphoSitePlus
S853TPGRPsQQKRKPhosphoSitePlus

Dephosphorylation site
TOPB1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000260810S471NBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
TOPB1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TOPB1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ATM_HUMANTOPB1_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANTOPB1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
TOPB1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006281DNA repairNASbiological_process
GO:0005634nucleusTAScellular_component
GO:0006259DNA metabolic processTASbiological_process
GO:0005694chromosomeIEAcellular_component
GO:0016605PML bodyIDAcellular_component
GO:0010212response to ionizing radiationIDAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0000922spindle poleIEAcellular_component
GO:0001673male germ cell nucleusIEAcellular_component
GO:0005815microtubule organizing centerIEAcellular_component
GO:0000794condensed nuclear chromosomeIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0006974response to DNA damage stimulusIDAbiological_process
GO:0005694chromosomeIDAcellular_component
GO:0003677DNA bindingIEAmolecular_function
GO:0008022protein C-terminus bindingTASmolecular_function


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