| UniProt/SwissProt ID: | TNR3_HUMAN |
| Description: | lymphotoxin beta receptor (TNFR superfamily, member 3) [Source:HGNC Symbol;Acc:6718] |
| Location: | chr12 p13.31 |
| Node attribute: | receptor; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S298 | PLLPIsGDVSP | HPRD | |
| S323 | VPQQQsPLDLT | PhosphoSitePlus; HPRD | |
| S302 | ISGDVsPVSTG | HPRD | |
| Dephosphorylation site |
| TNR3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000228918 | G336W | COSMIC | Lung Cancer | 20668451 | ENSP00000228918 | C148F | COSMIC | Lung Cancer | 20668451 | ENSP00000228918 | L196M | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000228918 | G398R | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000228918 | H349Y | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000228918 | Ovarian Cancer | Treatment (cisplatin-sensitive vs. cisplatin-resistant) | cell line | Up | 4.4 | 16319398 |
| Hyperphosphorylation site |
| TNR3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TNF14_HUMAN | TNR3_HUMAN | ligand -> receptor | HPMR |
| TNFB_HUMAN | TNR3_HUMAN | other | KEGG |
| TNFC_HUMAN | TNR3_HUMAN | other | KEGG |
| TNF14_HUMAN | TNR3_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04060 | Cytokine-cytokine receptor interaction |
| hsa05203 | Viral carcinogenesis |
| hsa04064 | NF-kappa B signaling pathway |
| hsa05166 | HTLV-I infection |
| hsa04672 | Intestinal immune network for IgA production |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB c | IEP | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0006915 | apoptotic process | IEA | biological_process |
| GO:2001238 | positive regulation of extrinsic apoptotic signali | IMP | biological_process |
| GO:0042802 | identical protein binding | IPI | molecular_function |
| GO:0071260 | cellular response to mechanical stimulus | IEP | biological_process |
| GO:0046330 | positive regulation of JNK cascade | IMP | biological_process |
| GO:0019048 | virus-host interaction | IEA | biological_process |
| GO:0031625 | ubiquitin protein ligase binding | IPI | molecular_function |