Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TNR3_HUMAN
Description:lymphotoxin beta receptor (TNFR superfamily, member 3) [Source:HGNC Symbol;Acc:6718]
Location:chr12 p13.31
Node attribute:receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S298PLLPIsGDVSPHPRD
S323VPQQQsPLDLTPhosphoSitePlus; HPRD
S302ISGDVsPVSTGHPRD

Dephosphorylation site
TNR3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000228918G336WCOSMICLung Cancer20668451
ENSP00000228918C148FCOSMICLung Cancer20668451
ENSP00000228918L196MBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000228918G398RBIOMARTBreast Cancer21930507, 21930502
ENSP00000228918H349YCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000228918Ovarian CancerTreatment (cisplatin-sensitive vs. cisplatin-resistant)cell lineUp4.416319398

Hyperphosphorylation site
TNR3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TNF14_HUMANTNR3_HUMANligand -> receptorHPMR
TNFB_HUMANTNR3_HUMANotherKEGG
TNFC_HUMANTNR3_HUMANotherKEGG
TNF14_HUMANTNR3_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04060Cytokine-cytokine receptor interaction
hsa05203Viral carcinogenesis
hsa04064NF-kappa B signaling pathway
hsa05166HTLV-I infection
hsa04672Intestinal immune network for IgA production

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007165signal transductionTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIEPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0006915apoptotic processIEAbiological_process
GO:2001238positive regulation of extrinsic apoptotic signaliIMPbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0071260cellular response to mechanical stimulusIEPbiological_process
GO:0046330positive regulation of JNK cascadeIMPbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0031625ubiquitin protein ligase bindingIPImolecular_function


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