| UniProt/SwissProt ID: | TNF14_HUMAN |
| Description: | tumor necrosis factor (ligand) superfamily, member 14 [Source:HGNC Symbol;Acc:11930] |
| Location: | chr19 p13.3 |
| Node attribute: | ligand; PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T161 | LGLAStITHGL | TNF | PhosphoSitePlus |
| T170 | GLYKRtPRYPE | TNF | PhosphoSitePlus |
| Y167 | ITHGLyKRTPR | TNF | PhosphoSitePlus |
| T163 | LASTItHGLYK | TNF | PhosphoSitePlus |
| Dephosphorylation site |
| TNF14_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000245912 | M1T | COSMIC | Hepatocellular Carcinoma | 21822264 | ENSP00000326940 | L62F | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000245912 | L98F | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000245912 | G188R | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| TNF14_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TNF14_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TNF14_HUMAN | TNR3_HUMAN | ligand -> receptor | HPMR |
| TNF14_HUMAN | TNR14_HUMAN | ligand -> receptor | HPMR |
| TNF14_HUMAN | TNR14_HUMAN | other | KEGG |
| TNF14_HUMAN | TNR3_HUMAN | other | KEGG |
| TNF14_HUMAN | TNF6B_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05168 | Herpes simplex infection |
| hsa04060 | Cytokine-cytokine receptor interaction |
| hsa04064 | NF-kappa B signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0042110 | T cell activation | NAS | biological_process |
| GO:0005164 | tumor necrosis factor receptor binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006917 | induction of apoptosis | TAS | biological_process |
| GO:0043027 | cysteine-type endopeptidase inhibitor activity inv | IDA | molecular_function |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0005125 | cytokine activity | IEA | molecular_function |
| GO:0043154 | negative regulation of cysteine-type endopeptidase | IDA | biological_process |
| GO:0008588 | release of cytoplasmic sequestered NF-kappaB | IDA | biological_process |
| GO:0043029 | T cell homeostasis | NAS | biological_process |
| GO:0042098 | T cell proliferation | NAS | biological_process |
| GO:0007165 | signal transduction | NAS | biological_process |
| GO:0005102 | receptor binding | IPI | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0071260 | cellular response to mechanical stimulus | IEP | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0005615 | extracellular space | IEA | cellular_component |
| GO:0006955 | immune response | IEA | biological_process |