Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TNR11_HUMAN
Description:tumor necrosis factor receptor superfamily, member 11a, NFKB activator [Source:HGNC Symbol;Acc:11908]
Location:chr18 q21.33
Node attribute:receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S463EPLVGsPKRGPPhosphoSitePlus; phosphoELM
S580LARRDsFAGNGPhosphoSitePlus

Dephosphorylation site
TNR11_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000269485M350LCOSMICLung Cancer20668451
ENSP00000269485A241TCOSMICBreast Cancer20668451
ENSP00000269485D78VCOSMICHead and Neck Cancer21798893
ENSP00000269485S519FCOSMICSkin Cancer21984974
ENSP00000269485P142SCOSMICSkin Cancer21984974
ENSP00000269485T173ACOSMICBreast Cancer20668451

Differential expressed protein
TNR11_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TNR11_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TNF11_HUMANTNR11_HUMANligand -> receptorHPMR
TNF11_HUMANTNR11_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04380Osteoclast differentiation
hsa04064NF-kappa B signaling pathway
hsa05323Rheumatoid arthritis
hsa04060Cytokine-cytokine receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0034612response to tumor necrosis factorISSbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0030316osteoclast differentiationIMPbiological_process
GO:0071812positive regulation of fever generation by positivISSbiological_process
GO:0004872receptor activityTASmolecular_function
GO:0051091positive regulation of sequence-specific DNA bindiIDAbiological_process
GO:0004888transmembrane signaling receptor activityIDAmolecular_function
GO:0043507positive regulation of JUN kinase activityIMPbiological_process
GO:0060086circadian temperature homeostasisISSbiological_process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cRCAbiological_process
GO:0008284positive regulation of cell proliferationTASbiological_process
GO:0051092positive regulation of NF-kappaB transcription facIMPbiological_process
GO:0071848positive regulation of ERK1 and ERK2 cascade via TIMPbiological_process
GO:0033209tumor necrosis factor-mediated signaling pathwayISSbiological_process
GO:0007267cell-cell signalingTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0002250adaptive immune responseIMPbiological_process
GO:0005031tumor necrosis factor-activated receptor activityISSmolecular_function
GO:0009897external side of plasma membraneIDAcellular_component
GO:0002548monocyte chemotaxisNASbiological_process
GO:0019955cytokine bindingIPImolecular_function
GO:0070555response to interleukin-1ISSbiological_process
GO:0007165signal transductionTASbiological_process
GO:0032496response to lipopolysaccharideISSbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0034097response to cytokine stimulusIMPbiological_process
GO:0071847TNFSF11-mediated signaling pathwayIMPbiological_process


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