Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TNIK_HUMAN
Description:TRAF2 and NCK interacting kinase [Source:HGNC Symbol;Acc:30765]
Location:chr3 q26.31
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S335EEENDsGEPSSPhosphoSitePlus
Y40TYGQVyKGRHVPkinasePhosphoSitePlus
S985RVYQTsPTDEDHPRD
S326YEYSGsEEEEEPhosphoSitePlus; HPRD
S720EPILEsPLQRTPhosphoSitePlus; HPRD
S680RTTSIsPALARPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y982VDPRVyQTSPTPhosphoSitePlus
T181AQLDRtVGRRNTNIKHPRD
Y36VGNGTyGQVYKPkinasePhosphoSitePlus
Y321KDETEyEYSGSHPRD
S707QPIRAsNPDLRPhosphoSitePlus; HPRD
T987YQTSPtDEDEEPhosphoSitePlus
S680RTTSIsPALARTNIKHPRD; SysPTM
T643QNSDPtSENPPPhosphoSitePlus
S678PQRTTsISPALPhosphoSitePlus; HPRD; phosphoELM
S755SQAGSsERTRVHPRD
S640MPRQNsDPTSETNIKHPRD; SysPTM
T187VGRRNtFIGTPPkinasePhosphoSitePlus
S16DEIDLsALRDPPhosphoSitePlus
Y519EKKPLyHYKEGPhosphoSitePlus
S560VANRIsDPNLPPhosphoSitePlus; HPRD
T1036RPHSDtPEIRKPhosphoSitePlus; HPRD
S175VDFGVsAQLDRPkinasePhosphoSitePlus
T319GEKDEtEYEYSHPRD
Y86NIATYyGAFIKPkinasePhosphoSitePlus
T677VPQRTtSISPAPhosphoSitePlus; HPRD
S348NLPGEsTLRRDHPRD
Y521KPLYHyKEGMSPhosphoSitePlus
Y475ALLLEyKRKQLPhosphoSitePlus
S915GEKKRsGHSDSHPRD
S324TEYEYsGSEEEPhosphoSitePlus; HPRD
T581VQPARtPPMLRPhosphoSitePlus; HPRD; phosphoELM
S640MPRQNsDPTSEPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S547RLNRQsSPAMPHPRD
S701GPRLGsQPIRAPhosphoSitePlus; HPRD
S795PSRPAsYKKAIPhosphoSitePlus
T181AQLDRtVGRRNHPRD
S729RTSSGsSSSSSPhosphoSitePlus
Y427EQRRHyEEQMRPhosphoSitePlus
S1116RVYYLsWLRNRCNHPhosphoSitePlus
Y446EHEQEyIRRQLPhosphoSitePlus
S938VQQSHsPAGTPPhosphoSitePlus
S766RANSKsEGSPVPhosphoSitePlus; HPRD
S769SKSEGsPVLPHPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S688LARKNsPGNGSPhosphoSitePlus; HPRD
Y499KQERDyLVSLQPhosphoSitePlus
Y963DSGTEyGMGSSPhosphoSitePlus
S764RVRANsKSEGSPhosphoSitePlus; HPRD; phosphoELM
T1267GVYVNtYGRITCNHPhosphoSitePlus
S726PLQRTsSGSSSHPRD
Y323ETEYEySGSEEHPRD
S574ESFSIsGVQPAPhosphoSitePlus
S1034NIRPHsDTPEIHPRD
T181AQLDRtVGRRNPkinasePhosphoSitePlus

Dephosphorylation site
TNIK_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000418378R976WBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000345352R947WBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000418916R968WBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000284483R1023WBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000349880R1002WBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000399511R1031WBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000418156R939WBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000419990R994WBIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
TNIK_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S764RTRVRANsKSEGSPVcolorectal cancer20530691PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
TNIK_HUMANTNIK_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
TNIK_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007256activation of JNKK activityIMPbiological_process
GO:0016055Wnt receptor signaling pathwayIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0007243intracellular protein kinase cascadeIDAbiological_process
GO:0005856cytoskeletonIDAcellular_component
GO:0006950response to stressIDAbiological_process
GO:0007010cytoskeleton organizationIMPbiological_process
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0005083small GTPase regulator activityIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0006468protein phosphorylationIDAbiological_process
GO:0005524ATP bindingNASmolecular_function
GO:0048814regulation of dendrite morphogenesisIDAbiological_process
GO:0055037recycling endosomeIEAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0046777protein autophosphorylationIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0031532actin cytoskeleton reorganizationIDAbiological_process
GO:0005737cytoplasmIDAcellular_component


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