| UniProt/SwissProt ID: | TNIK_HUMAN |
| Description: | TRAF2 and NCK interacting kinase [Source:HGNC Symbol;Acc:30765] |
| Location: | chr3 q26.31 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S335 | EEENDsGEPSS | PhosphoSitePlus | |
| Y40 | TYGQVyKGRHV | Pkinase | PhosphoSitePlus |
| S985 | RVYQTsPTDED | HPRD | |
| S326 | YEYSGsEEEEE | PhosphoSitePlus; HPRD | |
| S720 | EPILEsPLQRT | PhosphoSitePlus; HPRD | |
| S680 | RTTSIsPALAR | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| Y982 | VDPRVyQTSPT | PhosphoSitePlus | |
| T181 | AQLDRtVGRRN | TNIK | HPRD |
| Y36 | VGNGTyGQVYK | Pkinase | PhosphoSitePlus |
| Y321 | KDETEyEYSGS | HPRD | |
| S707 | QPIRAsNPDLR | PhosphoSitePlus; HPRD | |
| T987 | YQTSPtDEDEE | PhosphoSitePlus | |
| S680 | RTTSIsPALAR | TNIK | HPRD; SysPTM |
| T643 | QNSDPtSENPP | PhosphoSitePlus | |
| S678 | PQRTTsISPAL | PhosphoSitePlus; HPRD; phosphoELM | |
| S755 | SQAGSsERTRV | HPRD | |
| S640 | MPRQNsDPTSE | TNIK | HPRD; SysPTM |
| T187 | VGRRNtFIGTP | Pkinase | PhosphoSitePlus |
| S16 | DEIDLsALRDP | PhosphoSitePlus | |
| Y519 | EKKPLyHYKEG | PhosphoSitePlus | |
| S560 | VANRIsDPNLP | PhosphoSitePlus; HPRD | |
| T1036 | RPHSDtPEIRK | PhosphoSitePlus; HPRD | |
| S175 | VDFGVsAQLDR | Pkinase | PhosphoSitePlus |
| T319 | GEKDEtEYEYS | HPRD | |
| Y86 | NIATYyGAFIK | Pkinase | PhosphoSitePlus |
| T677 | VPQRTtSISPA | PhosphoSitePlus; HPRD | |
| S348 | NLPGEsTLRRD | HPRD | |
| Y521 | KPLYHyKEGMS | PhosphoSitePlus | |
| Y475 | ALLLEyKRKQL | PhosphoSitePlus | |
| S915 | GEKKRsGHSDS | HPRD | |
| S324 | TEYEYsGSEEE | PhosphoSitePlus; HPRD | |
| T581 | VQPARtPPMLR | PhosphoSitePlus; HPRD; phosphoELM | |
| S640 | MPRQNsDPTSE | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S547 | RLNRQsSPAMP | HPRD | |
| S701 | GPRLGsQPIRA | PhosphoSitePlus; HPRD | |
| S795 | PSRPAsYKKAI | PhosphoSitePlus | |
| T181 | AQLDRtVGRRN | HPRD | |
| S729 | RTSSGsSSSSS | PhosphoSitePlus | |
| Y427 | EQRRHyEEQMR | PhosphoSitePlus | |
| S1116 | RVYYLsWLRNR | CNH | PhosphoSitePlus |
| Y446 | EHEQEyIRRQL | PhosphoSitePlus | |
| S938 | VQQSHsPAGTP | PhosphoSitePlus | |
| S766 | RANSKsEGSPV | PhosphoSitePlus; HPRD | |
| S769 | SKSEGsPVLPH | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S688 | LARKNsPGNGS | PhosphoSitePlus; HPRD | |
| Y499 | KQERDyLVSLQ | PhosphoSitePlus | |
| Y963 | DSGTEyGMGSS | PhosphoSitePlus | |
| S764 | RVRANsKSEGS | PhosphoSitePlus; HPRD; phosphoELM | |
| T1267 | GVYVNtYGRIT | CNH | PhosphoSitePlus |
| S726 | PLQRTsSGSSS | HPRD | |
| Y323 | ETEYEySGSEE | HPRD | |
| S574 | ESFSIsGVQPA | PhosphoSitePlus | |
| S1034 | NIRPHsDTPEI | HPRD | |
| T181 | AQLDRtVGRRN | Pkinase | PhosphoSitePlus |
| Dephosphorylation site |
| TNIK_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000418378 | R976W | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000345352 | R947W | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000418916 | R968W | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000284483 | R1023W | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000349880 | R1002W | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000399511 | R1031W | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000418156 | R939W | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000419990 | R994W | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
| Differential expressed protein |
| TNIK_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| Site | Motif | Peptide | Cancer name | Pubmed | Source |
|---|---|---|---|---|---|
| S764 | RTRVRANsKSEGSPV | colorectal cancer | 20530691 | PhosphoSitePlus | |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TNIK_HUMAN | TNIK_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| TNIK_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007256 | activation of JNKK activity | IMP | biological_process |
| GO:0016055 | Wnt receptor signaling pathway | IEA | biological_process |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0007243 | intracellular protein kinase cascade | IDA | biological_process |
| GO:0005856 | cytoskeleton | IDA | cellular_component |
| GO:0006950 | response to stress | IDA | biological_process |
| GO:0007010 | cytoskeleton organization | IMP | biological_process |
| GO:0004674 | protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0005083 | small GTPase regulator activity | IEA | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | IDA | biological_process |
| GO:0005524 | ATP binding | NAS | molecular_function |
| GO:0048814 | regulation of dendrite morphogenesis | IDA | biological_process |
| GO:0055037 | recycling endosome | IEA | cellular_component |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0046777 | protein autophosphorylation | IDA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0031532 | actin cytoskeleton reorganization | IDA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |