Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TNFL6_HUMAN
Description:Fas ligand (TNF superfamily, member 6) [Source:HGNC Symbol;Acc:11936]
Location:chr1 q24.3
Node attribute:PPI(source); ligand; gene

Phosphorylation site
TNFL6_HUMAN do not have phosphorylation site.

Dephosphorylation site
TNFL6_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000356694G199SCOSMICSkin Cancer21984974
ENSP00000356694Y196CCOSMICLung Cancer20668451
ENSP00000356694T252NCOSMICLung Cancer20668451

Differential expressed protein
TNFL6_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TNFL6_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TNFL6_HUMANTNR6_HUMANligand -> receptorHPMR
TNFL6_HUMANTNR6_HUMANotherKEGG
TNFL6_HUMANTNF6B_HUMANotherKEGG
EGR1_HUMANTNFL6_HUMANTF -> target geneTRANSFAC
EGR3_HUMANTNFL6_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05320Autoimmune thyroid disease
hsa04650Natural killer cell mediated cytotoxicity
hsa04060Cytokine-cytokine receptor interaction
hsa05330Allograft rejection
hsa05164Influenza A
hsa05168Herpes simplex infection
hsa04722Neurotrophin signaling pathway
hsa05142Chagas disease (American trypanosomiasis)
hsa04210Apoptosis
hsa05200Pathways in cancer
hsa04940Type I diabetes mellitus
hsa04010MAPK signaling pathway
hsa05143African trypanosomiasis
hsa05332Graft-versus-host disease
hsa05162Measles

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016020membraneIEAcellular_component
GO:0005615extracellular spaceIDAcellular_component
GO:0005887integral to plasma membraneTAScellular_component
GO:0006919activation of cysteine-type endopeptidase activityIMPbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0006915apoptotic processIEAbiological_process
GO:0009897external side of plasma membraneIEAcellular_component
GO:0005125cytokine activityIEAmolecular_function
GO:0097190apoptotic signaling pathwayIDAbiological_process
GO:0043202lysosomal lumenIEAcellular_component
GO:0007267cell-cell signalingTASbiological_process
GO:0008625extrinsic apoptotic signaling pathway via death doIEAbiological_process
GO:0006917induction of apoptosisIDAbiological_process
GO:0005901caveolaIEAcellular_component
GO:0070062extracellular vesicular exosomeIDAcellular_component
GO:0043065positive regulation of apoptotic processIDAbiological_process
GO:0016023cytoplasmic membrane-bounded vesicleIEAcellular_component
GO:0006915apoptotic processTASbiological_process
GO:0005634nucleusIDAcellular_component
GO:0005102receptor bindingTASmolecular_function
GO:0046666retinal cell programmed cell deathIEAbiological_process
GO:0070265necrotic cell deathIDAbiological_process
GO:0048388endosomal lumen acidificationIEAbiological_process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIEPbiological_process
GO:0060554activation of necroptosis of activated-T cellsIDAbiological_process
GO:0045742positive regulation of epidermal growth factor recIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0060205cytoplasmic membrane-bounded vesicle lumenIEAcellular_component
GO:0016525negative regulation of angiogenesisIDAbiological_process
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0033554cellular response to stressIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIDAbiological_process
GO:0045121membrane raftIEAcellular_component
GO:0005164tumor necrosis factor receptor bindingIEAmolecular_function
GO:0043525positive regulation of neuron apoptotic processIEAbiological_process
GO:0006925inflammatory cell apoptotic processIEAbiological_process
GO:0006955immune responseIEAbiological_process
GO:0070848response to growth factor stimulusIEAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0030644cellular chloride ion homeostasisIEAbiological_process
GO:0060555activation of necroptosis by extracellular signalsIDAbiological_process
GO:0032496response to lipopolysaccharideIEAbiological_process