Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TLN1_HUMAN
Description:talin 1 [Source:HGNC Symbol;Acc:11845]
Location:chr9 p13.3
Node attribute:PPI(target); gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1130AGGLRsLAQAAVBSPhosphoSitePlus
S1732LGHKVsQMAQYPhosphoSitePlus
T2183MTKGItMATAKPhosphoSitePlus
S2040QNAAGsQEKLAPhosphoSitePlus; HPRD
Y2224CKEAAyHPEVAPhosphoSitePlus
S2096LGDLIsATKAAPhosphoSitePlus
T1616GGLIQtARALAPhosphoSitePlus; HPRD
Y2530IRQQQyKFLPSHPRD
Y81GDTMEyRKKQRPhosphoSitePlus
S1323AAKALsTDPAAVBSPhosphoSitePlus
S2357IAAATsALVKAHPRD
S128NHDEYsLVRELFERM_NPhosphoSitePlus
Y199RRKFFySDQNVFERM_NPhosphoSitePlus
Y2239LRALHyGRECAPhosphoSitePlus
T16GNVVKtMQFEPPhosphoSitePlus; HPRD
S2162LAVFCsPEPPAPhosphoSitePlus
S979QAQPDsPSAQLHPRD
Y1116QGNENyAGIAAVBSPhosphoSitePlus
Y2530IRQQQyKFLPSI_LWEQPhosphoSitePlus
S1201LNRCVsCLPGQVBSPhosphoSitePlus
Y1445AAQAAyLVGVSPhosphoSitePlus
Y1893QLTSDyGRLASVBSPhosphoSitePlus
S2338KEADEsLNFEEPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T1946PSDAYtKKELIVBSPhosphoSitePlus
T2171PAKTStPEDFIPhosphoSitePlus
S22MQFEPsTMVYDPhosphoSitePlus; HPRD
T142KKEEItGTLRKFERM_NPhosphoSitePlus
Y1777ALQLLyTAKEAPhosphoSitePlus
Y1945SPSDAyTKKELHPRD; phosphoELM
T2186GITMAtAKAVAPhosphoSitePlus
T571AETDYtAVGCATalin_middlePhosphoSitePlus
T144EEITGtLRKDKFERM_NPhosphoSitePlus
T167KQKLHtDDELNFERM_NPhosphoSitePlus; SysPTM
Y71KALDYyMLRNGPhosphoSitePlus; HPRD
T78LRNGDtMEYRKPhosphoSitePlus
T1324AKALStDPAAPVBSPhosphoSitePlus
S955PLLVQsCKAVAPhosphoSitePlus
Y1945SPSDAyTKKELVBSPhosphoSitePlus
T167KQKLHtDDELNHPRD; phosphoELM; SysPTM
T23QFEPStMVYDAPhosphoSitePlus; HPRD
T2281VAGSVtELIQAPhosphoSitePlus
S425LEDSVsPKKSTPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T2098DLISAtKAAAGPhosphoSitePlus
T568GDPAEtDYTAVTalin_middlePhosphoSitePlus
T941QHAAStPKASAPhosphoSitePlus
Y1737SQMAQyFEPLTPhosphoSitePlus
Y436VLQQQyNRVGKPhosphoSitePlus; HPRD; phosphoELM
Y26PSTMVyDACRIPhosphoSitePlus; HPRD; phosphoELM
T122ARIGItNHDEYFERM_NPhosphoSitePlus
S423TMLEDsVSPKKHPRD; SysPTM
Y127TNHDEySLVREFERM_NPhosphoSitePlus
Y1116QGNENyAGIAAHPRD; phosphoELM
S2535YKFLPsELRDEPhosphoSitePlus
Y70GKALDyYMLRNPhosphoSitePlus; HPRD; phosphoELM
Y570PAETDyTAVGCTalin_middlePhosphoSitePlus
T2030VLVEDtKVLVQPhosphoSitePlus
Y270FLPKEyVKQKGFERM_M; ACBPPhosphoSitePlus

Dephosphorylation site
TLN1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000316029E350QCOSMICHead and Neck Cancer21798893
ENSP00000316029P363SCOSMICLung Cancer20668451
ENSP00000316029H1175YCOSMICHead and Neck Cancer21984974
ENSP00000316029K322NBIOMARTBreast Cancer21930507, 21930502
ENSP00000316029A1489TCOSMICOvarian Cancer20668451
ENSP00000316029P229SCOSMICSkin Cancer21984974
ENSP00000316029N2194SCOSMICCentral Nervous System Neoplasms21817013
ENSP00000316029A2189VCOSMICBreast Cancer17932254
ENSP00000316029G1262ECOSMICLung Cancer20668451
ENSP00000316029E269KCOSMICHead and Neck Cancer21798893
ENSP00000316029E384KCOSMICHead and Neck Cancer21798893
ENSP00000316029S1875LCOSMICLung Cancer20668451
ENSP00000316029S423PCOSMICBreast Cancer20668451
ENSP00000316029I2182MCOSMICHead and Neck Cancer21798893
ENSP00000316029R797HCOSMICCentral Nervous System Neoplasms18772396
ENSP00000316029E1438*BIOMARTBreast Cancer21930507, 21930502
ENSP00000316029G791ECOSMICLung Cancer20668451
ENSP00000316029A2110VCOSMICBreast Cancer17932254
ENSP00000316029Q2259HCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000316029Hepatocellular CarcinomaNormal vs. Cancercell lineUp2.618646787
ENSP00000316029Breast CancerMetastasistissueDown18257521

Hyperphosphorylation site
TLN1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CAN2_HUMANTLN1_HUMANotherKEGG
TOPRS_HUMANTLN1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04510Focal adhesion
hsa05166HTLV-I infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006936muscle contractionTASbiological_process
GO:0005158insulin receptor bindingIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0005813centrosomeIDAcellular_component
GO:0007155cell adhesionIEAbiological_process
GO:0007043cell-cell junction assemblyTASbiological_process
GO:0030968endoplasmic reticulum unfolded protein responseTASbiological_process
GO:0007016cytoskeletal anchoring at plasma membraneNASbiological_process
GO:0043231intracellular membrane-bounded organelleIDAcellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0030168platelet activationTASbiological_process
GO:0006987activation of signaling protein activity involved TASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0001726ruffleISScellular_component
GO:0005856cytoskeletonIEAcellular_component
GO:0007596blood coagulationTASbiological_process
GO:0005200structural constituent of cytoskeletonNASmolecular_function
GO:0005925focal adhesionIEAcellular_component
GO:0005198structural molecule activityIEAmolecular_function
GO:0007044cell-substrate junction assemblyIEAbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0005925focal adhesionISScellular_component
GO:0017166vinculin bindingIPImolecular_function
GO:0006928cellular component movementNASbiological_process
GO:0005911cell-cell junctionICcellular_component
GO:0015629actin cytoskeletonIEAcellular_component
GO:0030866cortical actin cytoskeleton organizationIEAbiological_process
GO:0070062extracellular vesicular exosomeIDAcellular_component
GO:0003779actin bindingIEAmolecular_function
GO:0007411axon guidanceTASbiological_process
GO:0002576platelet degranulationTASbiological_process
GO:0032587ruffle membraneIEAcellular_component
GO:0030274LIM domain bindingIPImolecular_function