Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TLE1_HUMAN
Description:transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) [Source:HGNC Symbol;Acc:11837]
Location:chr9 q21.32
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S292PASTAsSASSTPhosphoSitePlus
S259NEDPSsPRASPPhosphoSitePlus
S263SSPRAsPAHSPCDC2RegPhos
S284LKKDAsSSPASPhosphoSitePlus; RegPhos
S239SSHYDsDGDKSPhosphoSitePlus
S244SDGDKsDDNLVPhosphoSitePlus
S239SSHYDsDGDKSCK2a1(CK2 alphaRegPhos
S253LVVDVsNEDPSPhosphoSitePlus
S259NEDPSsPRASPCDC2RegPhos
T319VLKSStPTPRSPhosphoSitePlus
S267ASPAHsPRENGCDC2RegPhos
Y692NKPDKyQLHLHWD40PhosphoSitePlus
S286KDASSsPASTAPhosphoSitePlus; HPRD
S267ASPAHsPRENGPhosphoSitePlus
S239SSHYDsDGDKSCK2_alphaphosphoELM
S263SSPRAsPAHSPPhosphoSitePlus
T312HEKAStPVLKSPhosphoSitePlus
S239SSHYDsDGDKSCK2_group RegPhos
S703ESCVLsLKFAYWD40PhosphoSitePlus
S285KKDASsSPASTPhosphoSitePlus; HPRD
S699LHLHEsCVLSLWD40PhosphoSitePlus

Dephosphorylation site
TLE1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000365682V686ECOSMICOvarian Cancer21720365
ENSP00000365682G730RCOSMICMelanoma21499247
ENSP00000365682G549ECOSMICSkin Cancer21984974
ENSP00000365682P728SCOSMICSkin Cancer21984974
ENSP00000365682E255ABIOMARTPancreatic Cancer21930507, 21930502
ENSP00000365682R194TBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
TLE1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TLE1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CSK21_HUMANTLE1_HUMANkinase -> substrateRobert H Newman (2013)
CDK1_HUMANTLE1_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANTLE1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
TLE1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0009887organ morphogenesisTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0010628positive regulation of gene expressionIMPbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0007275multicellular organismal developmentTASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0007165signal transductionTASbiological_process
GO:0005667transcription factor complexIEAcellular_component
GO:0005829cytosolIMPcellular_component
GO:0030178negative regulation of Wnt receptor signaling pathNASbiological_process
GO:0016055Wnt receptor signaling pathwayIEAbiological_process
GO:2000811negative regulation of anoikisIMPbiological_process
GO:0001106RNA polymerase II transcription corepressor activiIDAmolecular_function
GO:0008134transcription factor bindingIPImolecular_function
GO:0007219Notch signaling pathwayTASbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0006357regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0043124negative regulation of I-kappaB kinase/NF-kappaB cIDAbiological_process
GO:0003714transcription corepressor activityIEAmolecular_function
GO:0005634nucleusIDAcellular_component


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